Prem S. Paul – författare

This book, Mechanisms in the Pathogenesis of Enteric Diseases, is the outcome of the First International Rushmore Conference on Mechanisms in the Pathogenesis of En­ teric Diseases, held in September 1995 at Rapid City, South Dakota. The meeting was or­ ganized by members of the North-Central Regional Research Committee "NC-62," a United States Department of Agriculture-sponsored consortium of swine enteric disease researchers from land-grant institutions. This conference was conceived as a forum for an interdisciplinary discussion of mechanisms of infectious diseases. It was intended that such a discussion would stimulate cross-fostering of ideas and nurture synergistic collabo­ rations among scientists working on enteric diseases of humans and animals_. In atten­ dance, there were more than 140 participants from the United States and 12 foreign countries representing all of the world's continents. Participants brought expertise from many disciplines in both human and veterinary medicine. Multiple perspectives and an in­ formal atmosphere provided an environment for lively and thought-provoking discussions. Conference topics included Pathobiology of Gastroenteric Diseases, Mechanisms of Iden­ tity and Interaction between Host and Pathogen, Effector Mechanisms in the Pathogenesis of Enteric Diseases, Regulation of Pathogenic Activity in Enteric Diseases, and Novel Ap­ proaches to Prevention and Therapy of Enteric Diseases. Ten internationally renowned scientists gave keynote presentations in addition to 30 oral presentations and 39 poster presentations. The keynote speakers were Drs.

This volume covers the mechanisms of pathogenesis of enteric diseases. The topics include the epidemiology and pathobiology of enteric diseases, mechanisms of identity and interaction between host and pathogen, effector mechanisms in the pathogenesis and regulation of pathogenic activity in enteric diseases, and novel approaches to the prevention and therapy of enteric diseases. Diarrhoeal diseases caused by bacteria, viruses, and protozoa are among the most common diseases of animals and humans. They have also been among the most resistant diseases to prevent. Progress in the management of one disease is frequently overshadowed by the emergence of a new, more challenging enteric disease problem. The zoonotic character of many enteric pathogens links veterinary and medical concerns. At least five enteropathogens, Campylobacter jejuni, non-typhoid Salmonella, Escherichia coli O157:H7, Clostridium perfringens, and Cryptosporidium parvum, shed in the faeces of pigs, cattle, and/or poultry, are important causes of diarrhoea in human beings.

This book, Mechanisms in the Pathogenesis of Enteric Diseases 2, is an out­ come of the Second International Rushmore Conference on Mechanisms in the Pathogenesis of Enteric Diseases, held September 3D-October 3, 1998 in Rapid City, South Dakota, USA. Its chapters represent many of the reviews and papers presented at the conference. The meeting was organized by members of the North-Central Regional Research Committee "NC-62", a consortium of researchers of bovine and swine enteric diseases from land-grant institutions supported by the United States Department of Agriculture. The Rushmore Conferences were conceived as a forum for an interdiscipli­ nary discussion of mechanisms of infectious enteric diseases. It was intended that such a discussion would stimulate cross-pollination of ideas, and nurture synergistic collabora­ tions among scientists who might otherwise not interact. Enteric diseases are caused by widely divergent pathogens and parasites in broadly different settings, and affect multi­ ple organ systems. Some enteric diseases affect a single species, while others may affect multiple species, perhaps including human beings. Some enteric diseases were present in antiquity, while others have recently emerged. Knowledge regarding a particular disease or pathogen has frequently proven useful in understanding another disease or pathogen, because common themes in pathogenesis exist. As this knowledge base grows,strategies in the prevention and control of various enteric diseases often converge. Cross-discipli­ nary discussions and collaborations facilitate growth of this knowledge base, as well as development of tools for disease interdiction.