P.V. Mohanan – författare

Biomedical Product and Materials Evaluation: Standards and Ethics provides a much-needed overview of the procedures, issues, standards and ethical issues in the early development of biomedical products. The book covers a range of key biomedical products, from 3D printed organs and blood derived products, to stem calls and decellularized tissue products. Each chapter reviews a single product type, associated materials, biomedical applications, proven development strategies, and potential challenges. The core focus of the book is on the standardization and ethical aspects of biomedical product development, with these elements addressed and discussed in chapters dedicated to product evaluation.

This is a useful reference for academics, researchers and industry professionals in R&D groups with an interest in biomaterial research and production, as well as those working in the fields of biomedical engineering, biotechnology and toxicology.

Covers a variety of biomedical products, including specific biomaterials, organs-on-chips, wound care products, combinational products, and more Delves into strategies and considerations for product evaluation, including cytotoxicity assays, microbial and blood compatibility studies Discusses standardization and ethical hurdles in biomedical product development and how to overcome them

Next-Generation Antimicrobial Nanocoatings for Medical Devices and Implants provides a detailed, up-to-date overview of the nano-based antimicrobial coatings used to combat medical device-related biofilms. An introduction to biofilms and how they infect medical devices is included, as well as strategies/modification techniques used to target these biofilms. This book evaluates the various antimicrobial coatings formed using nanomaterials such as silver, inorganic materials, organic materials, carbon dots, surfactants, and electrospun fibers, specifically for us on medical devices and implants. Numerous coating methods are discussed, along with the biological characterizations of these coating materials, and their toxicological and environmental impact. This book is a useful reference for materials scientists, biomedical engineers, and those working on the development of novel biomaterials for use in medical devices and implants.Provides a range of nanomaterials for use in antimicrobial coatings, including electrospun fibers, surfactants, carbon quantum dots, and moreDetails various modification approaches for targeting biofilms, as well as nanocoating characterization and methods for use on medical devices and implantsAssesses the environmental and toxicological impact of antimicrobial nanocoatings

Human Organs-on-a-Chip Technology focuses on technology advancement from “organ-on-a-chip”, “multi organs-on-a-chip”, and the newest stage of “human organs-on-a-chip." Chapters investigate the design, simulation studies, device development, and application of microfluidic systems. In addition, they offer expert perspectives on the development of an alternative test system in the biological evaluation of drugs, cosmetics, chemicals, medical devices, and many others. Lastly, the book addresses issues related to the development of microfluidic devices and alternative test systems in biological and biomedical research.Explores organs-on-a-chip technology, from the basics, to advanced developments and existing challenges and recent research trends and applicationsReviews every aspect of microfluidic devices, including biological evaluation and targeted deliveryIncludes the latest information on regulatory updates

Advancements of AI in medical and biological sciences have opened new ways for drug development. Novel therapeutic molecules and their target action can be easily predicted and can be modified. AI helps in disease detection and diagnosis faster. The breakthrough of AI is made especially in the area of personalized precision medicine, host-pathogen interaction and predictive epidemiology. These approaches could help in faster decision-making with minimal errors that can improve risk analysis, especially disease diagnosis and selecting treatment strategy. In agricultural practices, an exact combination of fertilizers, pesticides, herbicides, soil management, water requirement analysis, yield prediction and overall crop management can be modified by implementing AI interventions. AI could provide a better improvement in agriculture, medical research, pharmaceuticals and bio-based industries for a sustainable life.The key features of this book are: AI in medical Sciences, biotechnology and drug discovery; Application of AI in Digital Pathology, cytology and bioinformatics; Overview of AI, Machine Learning and Deep Learning; Impact of Artificial Intelligence in Society; Artificial Intelligence in Pharmacovigilance; and Ethics in Artificial Intelligence. The volume aims to comprehensively cover the application of AI in biological sciences. It is a collection of contributions from different authors who have several years of experience in their specific areas. The book will be useful for pharma companies, CROs, product developers, students, researchers, academicians, policymakers and practitioners.

3D bioprinting is an emerging innovative technology that involves the fabrication of essential 3D functional biomedical constructs by combining cells and biomaterials with vital growth and differentiation factors. It aims to replicate the natural tissue milieu and holds great promise in fields like tissue engineering, regenerative medicine, drug development and testing, precision medicine, etc. 3D bioprinted disease-specific models help to study, screen the treatment methods and understand the mechanism of action. In personalized medicine, patient-specific tissue and organ constructs can be developed for specific surgeries and treatments tailored to a patient’s unique anatomy and genetics. 3D functional tissue construct addresses the problem of organ shortage as it lowers the risk of rejection of tissues and organs. The technique also replaces the need to experiment on animals and improves the accuracy of pre-clinical studies to test the safety and efficacy of new drugs in bioprinted tissues.This book provides comprehensive coverage of the application of 3D bioprinting technology. It is a collection of contributions by experts with cutting-edge know-how. The book is meant for medical practitioners, pharma companies, CROs, product developers, students, researchers, academicians, policymakers and practitioners.