Rachael Grace – författare
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2 produkter
2 produkter
Inbunden, Engelska, 2019
1 022 kr
Skickas inom 10-15 vardagar
This issue of Hematology/Oncology Clinics, Guest Edited by Drs. Rachael Grace and Russell E. Ware, will focus on�Pediatric Hematology. This issue is one of six selected for the year by the series Consulting Editors,�George P. Canellos and H. Franklin Bunn.�Topics include, but are not limited to,�Rare Congenital Hemolytic Anemias, Sickle Cell,�Thalassemia,�Neutropenia and rare leukocyte disorders in children,�Primary and Secondary Immune cytopenias,�Disorders of Iron overload,�Disorders of Iron metabolism, Approach to Hemophilia in a Changing Treatment Landscape, Von Willebrand disease,�Inherited platelet disorders,�Thrombosis,�Diagnostic evaluation and medical approach to complications and treatment of vascular anomalies,�New approaches and trials in Transfusion Medicine, and�Updates in Neonatal Hematology.
Häftad, Engelska, 2025
98 kr
Skickas inom 3-6 vardagar
Pyruvate kinase deficiency (PK deficiency) is a rare genetic disease that causes red blood cells to break apart easily (hemolysis). Some patients have no or few symptoms; others have very low numbers of red blood cells (hemolytic anemia) and need treatment with regular blood transfusions. Hemolysis occurs in everyone with PK deficiency. It increases the risk of complications that need monitoring, such as gallstones, iron overload, and low bone density. Treatment with mitapivat, which is taken as a tablet, activates pyruvate kinase and reduces anemia and hemolysis in about half of all adults with PK deficiency. Research into other new treatments, including gene therapy, is promising. Common supportive treatments include blood transfusions, removal of the spleen (splenectomy), and medications to remove excess iron from the blood (chelation therapy).