Rashid Ali – författare

The book focuses on the biological activities of ivermectin as well as the significant global utility of IVM since it was first used about 35 years ago.

Ivermectin (IVM) is a “wonder drug” containing a 16-membered macrocyclic lactone ring system in its structure and derived from the family of avermectins. It was isolated by the fermentation of the soil microorganism Streptomyces avermitilis by Satoshi Omura in 1960 and studied by William C. Campbell in 1981, which allowed for its treatment of onchocerciasis (River Blindness) in Africa. Both scientists subsequently received the 2015 Nobel Prize in Physiology or Medicine. It was approved by the FDA in 1997 for the treatment of Strongyloidiasis and crusted scabies in AIDS patients. After that, IVM has attracted the tremendous attention of the scientific community and has been used for diverse purposes, including as an inhibitor of the causative virus (SARS-CoV-2).

The chief purpose of this volume is to focus on the chemistry and biological activities of ivermectin. The chapters have been arranged in a systematic manner, starting from the historical background and synthesis of IVM to the pharmacological and environmental aspects, followed by diverse applications. Although the usage of ivermectin for the treatment of COVID-19 remains under investigation and controversial, one of the chapters is dedicated to its use. The anti-parasitic, anti-malarial, anti-cancer, and anti-inflammatory activities of IVM are discussed in detail. The anthelminthic and insecticidal roles of IVM are briefly described and there are several cases of IVM in dermatology.

Audience

Researchers, scientists, and postgraduate students working in the fields of organic synthesis, medicinal chemistry, medical science, pharmacy, biotechnology and biomedical sciences.

The book focuses on the biological activities of ivermectin as well as the significant global utility of IVM since it was first used about 35 years ago.

Ivermectin (IVM) is a “wonder drug” containing a 16-membered macrocyclic lactone ring system in its structure and derived from the family of avermectins. It was isolated by the fermentation of the soil microorganism Streptomyces avermitilis by Satoshi Omura in 1960 and studied by William C. Campbell in 1981, which allowed for its treatment of onchocerciasis (River Blindness) in Africa. Both scientists subsequently received the 2015 Nobel Prize in Physiology or Medicine. It was approved by the FDA in 1997 for the treatment of Strongyloidiasis and crusted scabies in AIDS patients. After that, IVM has attracted the tremendous attention of the scientific community and has been used for diverse purposes, including as an inhibitor of the causative virus (SARS-CoV-2).

The chief purpose of this volume is to focus on the chemistry and biological activities of ivermectin. The chapters have been arranged in a systematic manner, starting from the historical background and synthesis of IVM to the pharmacological and environmental aspects, followed by diverse applications. Although the usage of ivermectin for the treatment of COVID-19 remains under investigation and controversial, one of the chapters is dedicated to its use. The anti-parasitic, anti-malarial, anti-cancer, and anti-inflammatory activities of IVM are discussed in detail. The anthelminthic and insecticidal roles of IVM are briefly described and there are several cases of IVM in dermatology.

Audience

Researchers, scientists, and postgraduate students working in the fields of organic synthesis, medicinal chemistry, medical science, pharmacy, biotechnology and biomedical sciences.

This text introduces the modern concepts relevant to system engineering design and manufacturing from a 4th Industrial Revolution perspective.

The book surveys the current status and cutting edge in Computer Aided Design and Computer Aided Manufacturing (CAD/CAM). This bridges the gaps between academic research and industry. It consists of seven parts and seventeen chapters that first structure the subject areas and later detail the main topics under consideration. Each part of the book and each chapter contains a prelude guiding the reader in a systematic way to the next part or topic.

The book explains concepts using state-of-the-art teaching methods, using objectives, learning outcomes and review questions. MS PowerPoint Slides and Solution Manual for instructors are available online as well as videos.

This book discusses the applications of different soft computing techniques for the web-based systems and services. The respective chapters highlight recent developments in the field of soft computing applications, from web-based information retrieval to online marketing and online healthcare. In each chapter author endeavor to explain the basic ideas behind the proposed applications in an accessible format for readers who may not possess a background in these fields.

This carefully edited book covers a wide range of new applications of soft computing techniques in Web recommender systems, Online documents classification, Online documents summarization, Online document clustering, Online market intelligence, Web usage profiling, Web data extraction, Social network extraction, Question answering systems, Online health care, Web knowledge management, Multimedia information retrieval, Navigation guides, User profiles extraction, Web-based distributed information systems,  Web security applications, Internet of Things Applications and so on.

The book is aimed for researchers and practitioner who are engaged in developing and applying intelligent systems principles for solving real-life problems. Further, it has been structured so that each chapter can be read independently of the others.