Raymond E. March – författare

A definitive reference, completely updated Published in 1989, the First Edition of this book, originally entitled Quadrupole Storage Mass Spectrometry, quickly became the definitive reference in analytical laboratories worldwide. Revised to reflect scientific and technological advances and new applications in the field, the Second Edition includes new chapters covering:* New ion trap instruments of high sensitivity* Peptide analysis by liquid chromatography/ion trap tandem mass spectrometry* Analytical aspects of ion trap mass spectrometry combined with gas chromatography* Simulation of ion trajectories in the ion trap One additional chapter discusses the Rosetta mission, a "comet chaser" that was sent on a ten-year journey in 2004 to study the comet Churyumov-Gerasimenko using, among other instruments, a GC/MS system incorporating a specially designed ion trap mass spectrometer. This comprehensive reference also includes discussions of the history of the quadrupole ion trap, the theory of quadrupole mass spectrometry, the dynamics of ion-trapping chemistry in the quadrupole ion trap, the cylindrical ion trap, miniature traps, and linear ion traps. Complete with conclusions and references, this primer effectively encapsulates the body of knowledge on quadrupole ion trap mass spectrometry. With its concise descriptions of the theory of ion motion and the principles of operation, Quadrupole Ion Trap Mass Spectrometry, Second Edition is ideal for new users of quadrupole devices, as well as for scientists, researchers, and graduate and post-doctoral students working in analytical laboratories.

Fundamentals of Ion Trap Mass Spectrometry presents an account of the development and theory of the quadrupole ion trap and its utilization as an ion storage device, a reactor for ion/molecular reactions, and a mass spectrometer. It also expands the appreciation of ion traps from that of a unique arrangement of electrodes of hyperbolic form (and having a pure quadrupole field) to a series of ion traps having fields with hexapole and octopole components and introduces the practical ion trapping device in which electrode spacing has been increased.The fundamentals of ion trap are covered in four chapters, beginning with the origin of the ion trap, its development and operating principles, and improvements in performance. The second part focuses on the environment within the ion trap -- the movement of ions within the trap -- and how this movement is modified by repeated collisions of the ions with buffer gas atoms of helium, and on the collisions of ions with molecules that lead to chemical change. The critical role of collisions in focusing the ion cloud for subsequent operations is emphasized.This important reference presents a coherent picture of the present status of research in the ion trapping field to facilitate the entree of potential ion trappers and provide a backdrop for ion trap research and development in the future.

By delivering concentrated information in three different volumes, the editors of the Practical Aspects of Ion Trap Mass Spectrometry mini-series present in-depth reviews on mainstream developments in each active and popular area. Contributing authors provide concise reports illustrating successful approaches to difficult analytical problems across the basic scientific disciplines.Ion Trap Instrumentation, the second volume in the series, conveys an appreciation of the ion trap as a versatile instrument which is used successfully in research and in applications, often in tandem with other instruments or components, such as external ion sources and lasers.The book begins with a discussion of high resolution mass spectrometry and mass measurement accuracy. It then demonstrates that trajectories of high kinetic energy ions can be controlled so that such ions are confined. It provides applications of lasers to the study of trapped ions the laser photodissociation of gaseous ions confined within the ion trap. The book concludes with physics applications of the ion trap, in particular, the Penning trap and the Paul trap.

Reflecting the substantial increase in popularity of quadrupole ion traps and Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers, Practical Aspects of Trapped Ion Mass Spectrometry, Volume IV: Theory and Instrumentation explores the historical origins of the latest advances in this expanding field. It covers new methods for trapping ions, such as the Orbitrap™, the digital ion trap (DIT), the rectilinear ion trap (RIT), and the toroidal ion trap; the development and application of the quadrupole ion trap (QIT) and the quadrupole linear ion trap (LIT); and the introduction of high-field asymmetric waveform ion mobility spectrometry (FAIMS).After a combined appreciation and historical survey of mass spectrometry and a discussion of how improved capabilities for microfabrication have led to interest in arrays of ion traps, the book examines the theory and practice of the Orbitrap mass analyzer, the rectangular waveform-driven DIT mass spectrometer, FAIMS, and ion traps with circular geometries. It next discusses ion accumulation for increasing sensitivity in FT-ICR spectrometry, a radio frequency-only-mode event for Penning traps in FT MS, and an FT operating mode applied to a 3D-QIT. The text then presents three behavioral aspects of quadrupole rod sets, before illustrating the development of the 3D-QIT in recent years. The final chapters explore photodissociation in ion traps and the chemical and photochemical studies of metal dication complexes in a 3D-QIT.In this volume that spans twenty-one chapters, a stellar panel of leading experts and up-and-coming researchers presents a cohesive, global, and up-to-date view of the practical aspects of using trapped ion devices. A companion to Volume V: Applications of Ion Trapping Devices, the book authoritatively covers the theory involved as well as the instrumentation currently used in this dynamic field.

Reflecting the substantial increase in popularity of quadrupole ion traps and Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometers, Practical Aspects of Trapped Ion Mass Spectrometry, Volume IV: Theory and Instrumentation explores the historical origins of the latest advances in this expanding field. It covers new methods for trapping ions, such as the Orbitrap™, the digital ion trap (DIT), the rectilinear ion trap (RIT), and the toroidal ion trap; the development and application of the quadrupole ion trap (QIT) and the quadrupole linear ion trap (LIT); and the introduction of high-field asymmetric waveform ion mobility spectrometry (FAIMS).After a combined appreciation and historical survey of mass spectrometry and a discussion of how improved capabilities for microfabrication have led to interest in arrays of ion traps, the book examines the theory and practice of the Orbitrap mass analyzer, the rectangular waveform-driven DIT mass spectrometer, FAIMS, and ion traps with circular geometries. It next discusses ion accumulation for increasing sensitivity in FT-ICR spectrometry, a radio frequency-only-mode event for Penning traps in FT MS, and an FT operating mode applied to a 3D-QIT. The text then presents three behavioral aspects of quadrupole rod sets, before illustrating the development of the 3D-QIT in recent years. The final chapters explore photodissociation in ion traps and the chemical and photochemical studies of metal dication complexes in a 3D-QIT.In this volume that spans twenty-one chapters, a stellar panel of leading experts and up-and-coming researchers presents a cohesive, global, and up-to-date view of the practical aspects of using trapped ion devices. A companion to Volume V: Applications of Ion Trapping Devices, the book authoritatively covers the theory involved as well as the instrumentation currently used in this dynamic field.

Widely used in medical research, pharmaceutical and fine chemicals industries, biological and physical sciences, and security and environmental agencies, mass spectrometry techniques are continually under development. In Practical Aspects of Trapped Ion Mass Spectrometry: Volume V, Applications of Ion Trapping Devices, an international panel of authors presents a world-wide view of the practical aspects of recent progress using trapped ion devices.In contrast to previous texts, which have concentrated generally on a single or limited range of ion trapping techniques, a key feature of this compilation of contributions is its coverage of all the ion trapping techniques currently in use. Spanning sixteen chapters, the text examines: Ion/neutral and ion/ion reactionsStructural characterization of proteins and peptides using quadrupole ion trap mass spectrometry, Fourier transform – ion cyclotron resonance (FT-ICR) mass spectrometry, and traveling wave ion mobility mass spectrometryIon spectroscopy and electron diffractionConformational analysis of protein isobaric charge statesPractical examples of trapped-ion technology that reflect the wide diversity of applications of trapped-ion devicesThis text is the first detailed account of the application of new and established mass spectrometric techniques utilizing trapped or confined ions for prolonged investigation and increased sensitivity. Each chapter contains complete references and utilizes a consistent format and writing style, with all terms, acronyms, procedures, and equations thoroughly explained. The strong editorial input to the diverse sections enables readers to readily appreciate the commonalities of topics ranging from theory of instrument operation to proteins, flavonoids, atomic clocks, and single ion mass spectrometry.