Richard B. Moss – Författare
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2 produkter
2 180 kr
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In Cystic Fibrosis: Infection, Immunopathology, and Host Response, Richard Moss has organized a vanguard survey of the latest strategies for the control and reversal of this deadly disease that the tremendous advances in experimental medicine during the 1980s have made possible. These up-to-date reviews address both the nature and consequences of the complex interactions between microbial pathogens and respiratory epithelial surfaces that are of special interest to biomedical scientists and physicians concerned with the clinical manifestations of the disease's typically disordered cell biology. Chapters by leading experimental and clinical pathologists cover a broad spectrum of topics, including: the relationship between atopy and cystic fibrosis impact of respiratory viral infections in patients with cystic fibrosis In ammation in the lung in cystic fibrosis drug allergy in cystic fibrosis. Cystic Fibrosis: Infection, Immunopathology, and Host Response is today's essential resource for all microbiologists, clinical immunologist, allergists, infectious disease specialists, pulmonologists, and other clinical investigators and physicians interested in either research or patient care.
1 094 kr
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This work is concerned with Cystic Fibrosis (CF), the most common fatal genetic disease in the Caucasian population. The decade of the 1980s was one of spectacular progress in understanding the genetic and molecu lar basis of CF. The research breakthroughs of the decade began with the first fundamental insights, published in 1981-1983, into the basic cellular pathophysiology of CF with demonstrations of altered ion transport in spe cialized exocrine epithelial tissues (1-3). Research progress shifted into a triumph of "reverse genetics," using restriction-fragment-Iength polymor phism DNA technology (4), with the localization of the CF gene to a region of chromosome 7 (5-7). Understanding, accelerated by an explOSion of in vitro methodologies for epithelial cell culture and transformation, allowed and physiological studies (8-11); these focused, controlled biochemical with increasing precision, on the molecular pathology of distal steps in the regulatory pathways for epithelial ion transport (12-19). Finally, the "end of the beginning" occurred in late 1989 with one of the great achievements of molecular genetics, the isolation and cloning of the CF gene (20). As a result, we now have a CF gene product, the cystic fibrosis transmembrane regulator (CFfR), possessing predicted amino acid sequence, suggested tertiary structure, and possible transmembrane transport function (21). These amazing developments have set the stage for the next round of advances, which surely will include: 1.