Richard J. Barohn - Böcker

Dr. Richard Barohn and Dr. Mazen Dimachkie lead this publication on Motor Neuron Disease. Focus is on ALS, with inclusion of primary lateral sclerosis, primary muscular atrophy, leg amyotrophic diplegia, brachial amyotropic diplegia, and isolate bulbar ALS. Among the topics presented are. Patterns of weakness, classification of motor neuron disease� & clinical diagnosis of sporadic ALS;� Potential environmental factors in ALS;� Neuropathology;� Spinal muscular atrophy; Complementary and alternative therapies in ALS frontotemporal dysfunction and dementia in ALS;� Symptoms management and end of life care;� Research approaches to slowing progression of ALS; Familial ALS; Kennedy disease and more. Information in this issue presents: Description of the problem (Incidence, Prevalence, Severity, Natural history); 2. Review of pertinent data;� Controversial areas discussing aspects such as areas of practice for which there are disagreements and why? What are the arguments and counter arguments and what data support them?;� Conclusions using levels of clinical evidence that support or refute an intervention. Procedural steps are provided for diagnostic and treatment discussions along with clinical cases.

This issue of Neurologic Clinics, edited by Dr. Mazen M. Dimachkie and Dr. Richard J. Barohn, focuses on Neuromuscular Junction Disorders. Topics include--but are not limited to--History of myasthenia gravis and neuromuscular junction disorders; Practical immunology of the neuromuscular junction; Practical anatomy of the neuromuscular junction in health and disease; Generalized myasthenia gravis; Ocular myasthenia gravis; Diagnosis of myasthenia gravis; MuSK and myasthenia gravis due to other autoantibodies; Treatment of myasthenia gravis; Evidenced-based approach of thymectomy for myasthenia gravis; Myasthenia gravis and pregnancy; Congenital myasthenic syndromes; Botulism; Lambert-Eaton myasthenic syndrome; and Measuring clinical treatment response in myasthenia gravis.

In this issue of Neurologic Clinics, guest editors Drs. Richard J. Barohn and Mazen M. Dimachkie bring their considerable expertise to the topic of Peripheral Neuropathies. Top experts discuss a pattern-recognition approach to neuropathy and neuronopathy; laboratory evaluation of peripheral neuropathy; entrapment neuropathies; cryptogenic sensory polyneuropathy and metabolic syndrome; and more.

Peripheral Neuropathy is a neurologic disorder characterized by damage to the peripheral nervous system, the part of the nervous system outside the central nervous system that connects it to all parts of the body. Over 100 forms of peripheral neuropathy have been identified. This issue of Neurologic Clinics features 12 articles about this disease that are of most interest to the clinician. Articles include: Diabetic Neuropathy; GBS and Variants; CIDP and Symmetrical Variants; Laboratory Evaluation of Peripheral Neuropathy; Treatment of Painful Peripheral Neuropathy;Cryptogenic Sensory Polyneuropathy; Vasculitic Neuropathy; Hereditary Neuropathy; Entrapment Neuropathy; Multifocal Motor Neuropathy and Multifocal Acquired Demyelinating Sensory and Motor Neuropathy; Nutritional Neuropathies.

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