Richard J. Santen – författare

Atthebeginningofthe21thcentury,hormone associated tumorsmadeupnotless 1 than30 40%ofallhumancancers. Thus,theimportanceoftheproblem both me- calandsocial was thefirstreasonforthecreationofthisvolume. Accordingly, the firstgoalofthebookwastoreviewdifferent aspectsoftheextensivefieldofresearch intheareacoveredbythenotion'hormonesandcancer'. First,howeverdoesnotnecessarily meanmain.Mostofus knowthatscienceis aboutaskingquestions and finding credibleways to answerthem and that it works bestina culturethatwelcomes challenges toprevailing dogmas.'Thus,theprincipal aimof thisvolumeis to describethesenew and attractive ideasandmethodswhich haveanimatedoncoendocrinolgyin recentyears.Tofulfill thistask,theco editors of thebookwereguidedbya desireto describe therichinnovation inthisfield. Asaresult,thevolumeisdevotedtothenew developments insuchtopicsas mechanisms ofhormonal carcinogenesis (contributions ofJ. Chenetal;J.RussoandI. Russo; L.Berstein), epidemiology andriskfactors (contributions ofS.Ukraintsevaet al;A.Hjartakeretal;A.H.EliassenandS.Hankinson), hormoneproductionbytumor tissue(contributionofS.BulunandE.Simpson) andhormonal sensitivityofthelatter (contribution of C.Langeet al),genesis,dichotomy and endocrinology of cancerin females (contribution of C. Griindker et al), pharmacogenomics and proteomics in oncoendocrinology (contributions ofD. Tysonand D. Ornstein; R. Weinshilboum), biological coreofhormonalandantihormonal therapyofcancer(contributions ofR. Santenetal;A.Buttetal;S.SenguptaandV. C.Jordan)anditsprevention (T. Powles' contribution). Asoncewassaidbyprominentwriter:'Novelistsareeither"large audience" or"small audience'".' Wearehopingthatreadership ofthebook(whichtestifies that endocrinologyofcancerhasgonealongandfruitful way)willincreasegradually and receivefurtherstimulus neededfor subsequent achievements inthisinteresting area. Lev M Berstein, MD, PhD, DMS RichardJ. Santen, MD 1. Parkin DM, Fernandez LM. Use of statistics to assess the global burden of breast cancer. Breast J 2006; 12(Suppl 1):S70 80. 2. Omenn GS. Grand challenges and great opportunities in science, technology, and public policy. Science 2006; 314:1696 704. 3. Bellow S. Something to Remember Me By: Three Tales. New York: Viking, 1991. v ABOUT THE EDITORS...

Patients with a variety of tumors present to the physician because of clinical manifestations of hormones secreted in excess. This phenomenon attracted the investigative interest of such pioneers as Harvey Cushing who recognized that pituitary tumors may cause acromegaly and Charles Mayo who associated hyper­ tension with adrenal medullary neoplasms. Current int~rest in endocrine-related tumors has intensified because of the explosive development of newer methodol­ ogy for their study. Specific measurements of secretory products, hybridization assays to identify products of genomic translation and quantitative assessment of tissue hormone receptors have provided means of characterizing and precisely following patients with endocrine-related tumors. Treatments based upon these advances are rapidly proliferating. The current volume attempts to synthesize much of this recent information with the goal of providing a sound basis for making clinical judgements regarding diagnosis and management. Tumors of endocrine glandular tissues commonly confront practicing physi­ cians with difficult management problems. Several unique features of these tumors necessitate collaboration among various specialty disciplines in order to resolve these problems and to provide a high level of clinical care. For example, endocrine neoplasms secrete active hormones or hormone precursors which produce clinical manifestations most familiar to endocrinologists. Certain thera­ pies such as radioactive iodine for thyroid cancer take advantage of the hormone­ responsiveness of these tumors to facilitate treatment. These aspects require individuals trained in endocrinology to implement complex diagnostic and thera­ peutic maneuvers.

Atthebeginningofthe21thcentury,hormone associated tumorsmadeupnotless 1 than30 40%ofallhumancancers. Thus,theimportanceoftheproblem both me- calandsocial was thefirstreasonforthecreationofthisvolume. Accordingly, the firstgoalofthebookwastoreviewdifferent aspectsoftheextensivefieldofresearch intheareacoveredbythenotion'hormonesandcancer'. First,howeverdoesnotnecessarily meanmain.Mostofus knowthatscienceis aboutaskingquestions and finding credibleways to answerthem and that it works bestina culturethatwelcomes challenges toprevailing dogmas.'Thus,theprincipal aimof thisvolumeis to describethesenew and attractive ideasandmethodswhich haveanimatedoncoendocrinolgyin recentyears.Tofulfill thistask,theco editors of thebookwereguidedbya desireto describe therichinnovation inthisfield. Asaresult,thevolumeisdevotedtothenew developments insuchtopicsas mechanisms ofhormonal carcinogenesis (contributions ofJ. Chenetal;J.RussoandI. Russo; L.Berstein), epidemiology andriskfactors (contributions ofS.Ukraintsevaet al;A.Hjartakeretal;A.H.EliassenandS.Hankinson), hormoneproductionbytumor tissue(contributionofS.BulunandE.Simpson) andhormonal sensitivityofthelatter (contribution of C.Langeet al),genesis,dichotomy and endocrinology of cancerin females (contribution of C. Griindker et al), pharmacogenomics and proteomics in oncoendocrinology (contributions ofD. Tysonand D. Ornstein; R. Weinshilboum), biological coreofhormonalandantihormonal therapyofcancer(contributions ofR. Santenetal;A.Buttetal;S.SenguptaandV. C.Jordan)anditsprevention (T. Powles' contribution). Asoncewassaidbyprominentwriter:'Novelistsareeither"large audience" or"small audience'".' Wearehopingthatreadership ofthebook(whichtestifies that endocrinologyofcancerhasgonealongandfruitful way)willincreasegradually and receivefurtherstimulus neededfor subsequent achievements inthisinteresting area. Lev M Berstein, MD, PhD, DMS RichardJ. Santen, MD 1. Parkin DM, Fernandez LM. Use of statistics to assess the global burden of breast cancer. Breast J 2006; 12(Suppl 1):S70 80. 2. Omenn GS. Grand challenges and great opportunities in science, technology, and public policy. Science 2006; 314:1696 704. 3. Bellow S. Something to Remember Me By: Three Tales. New York: Viking, 1991. v ABOUT THE EDITORS...

Patients with a variety of tumors present to the physician because of clinical manifestations of hormones secreted in excess. This phenomenon attracted the investigative interest of such pioneers as Harvey Cushing who recognized that pituitary tumors may cause acromegaly and Charles Mayo who associated hyper­ tension with adrenal medullary neoplasms. Current int~rest in endocrine-related tumors has intensified because of the explosive development of newer methodol­ ogy for their study. Specific measurements of secretory products, hybridization assays to identify products of genomic translation and quantitative assessment of tissue hormone receptors have provided means of characterizing and precisely following patients with endocrine-related tumors. Treatments based upon these advances are rapidly proliferating. The current volume attempts to synthesize much of this recent information with the goal of providing a sound basis for making clinical judgements regarding diagnosis and management. Tumors of endocrine glandular tissues commonly confront practicing physi­ cians with difficult management problems. Several unique features of these tumors necessitate collaboration among various specialty disciplines in order to resolve these problems and to provide a high level of clinical care. For example, endocrine neoplasms secrete active hormones or hormone precursors which produce clinical manifestations most familiar to endocrinologists. Certain thera­ pies such as radioactive iodine for thyroid cancer take advantage of the hormone­ responsiveness of these tumors to facilitate treatment. These aspects require individuals trained in endocrinology to implement complex diagnostic and thera­ peutic maneuvers.