Richard McCarty - Böcker

Stress has been recognized as an important factor in the development or recurrence of various mental disorders, from major depressive disorder to bipolar disorder to anxiety disorders. Stressful stimuli also appear to exert their effects by acting upon individuals with susceptible genotypes. Over the past 50 years, animal models have been developed to study these dynamic interactions between stressful stimuli and genetically susceptible individuals during prenatal and postnatal development and into adulthood. Stress and Mental Disorders: Insights from Animal Models begins with a discussion of the history of psychiatric diagnosis and the recent goal of moving toward precision psychiatry, followed by a review of clinical research on connections between stressful stimuli and the development of psychiatric disorders. Chapters are also included on neuroendocrine, immune, and brain systems involved in responses to stress. Additional chapters focus on the development of animal models in psychiatry and the susceptibility of the developing organism to stressful stimuli. Subsequent chapters are devoted to animal models of specific stress-sensitive psychiatric disorders, including schizophrenia, autism spectrum disorders, bipolar disorder, anxiety disorders, depression, and post-traumatic stress disorder. These chapters also focus on identification of promising molecular targets for development of new drug therapies. The section concludes with a chapter on animal models of resilience to stress-induced behavioral alterations as a newer approach to understanding why some animals are susceptible to stress and others are resilient, even though they are essentially genetically identical. The final chapter discusses how these basic laboratory studies are providing promising leads for future breakthroughs in the diagnosis, treatment, and prevention of mental disorders.

The theory of action underlying Immanuel Kant's ethical theory is the subject of this book. What 'maxims' are, and how we act on maxims, are explained here in light of both the historical context of Kant's thought, and his classroom lectures on psychology and ethics. Arguing against the current of much recent scholarship, Richard McCarty makes a strong case for interpreting Kant as having embraced psychological determinism, a version of the 'belief-desire model' of human motivation, and a literal, 'two-worlds' metaphysics. On this interpretation, actions in the sensible world are always effects of prior psychological causes. Their explaining causal laws are the maxims of agents' characters. And agents act freely if, acting also in an intelligible world, what they do there results in their having the characters they have here, in the sensible world. McCarty additionally shows how this interpretation is fruitful for solving familiar problems perennially plaguing Kant's moral psychology.

The field of catecholamine research has not undergone comprehensive review for four years (since 1998). In the interim, a tremendous amount of new information, obtained using molecular, genetic, neurochemical and nuclear scanning techniques, has substantiated the important roles of catecholamine systems in development, cardiovascular function, psychiatric disorders, neurodegenerative diseases and metabolism. This volume, based on the Ninth International Catecholamine Symposium, should have a substantial and lasting impact on medical science.

Deriving the latest material from the Seventh Symposium on Catecholamines and other Neurotransmitters in Stress held in the Slovak Republic, Stress: Neural, Endocrine and Molecular Studies presents some of the latest research into stress, focusing on catecholamines and other neurotransmitter molecules. Topics covered include:Peripheral influences on the stress response Central influences on the stress response Molecular regulation during stress Neural-endocrine-immune interactions Stress during development and aging Stress hormone receptors Clinical aspects of stress.Stress: Neural, Endocrine and Molecular Studies is particularly suitable for graduates and researchers in the disciplines of neuroscience, endocrinology, medicine, immunology, cell and molecular biology, biochemistry, pharmacology and stress research.

Part of the Blackwell Readings in the History of Philosophy series, this survey of late modern philosophy focuses on the key texts and philosophers of the period whose beliefs changed the course of western thought. Gathers together the key texts from the most significant and influential philosophers of the late modern era to provide a thorough introduction to the period. Features the writings of Locke, Berkeley, Hume, Leibniz, Kant, Rousseau, Bentham and other leading thinkers. Examines such topics as empiricism, rationalism, and the existence of God. Readings are accompanied by expert commentary from the editors, who are leading scholars in the field.

Part of the Blackwell Readings in the History of Philosophy series, this survey of late modern philosophy focuses on the key texts and philosophers of the period whose beliefs changed the course of western thought. Gathers together the key texts from the most significant and influential philosophers of the late modern era to provide a thorough introduction to the period. Features the writings of Locke, Berkeley, Hume, Leibniz, Kant, Rousseau, Bentham and other leading thinkers. Examines such topics as empiricism, rationalism, and the existence of God. Readings are accompanied by expert commentary from the editors, who are leading scholars in the field.

The field of catecholamine research has not undergone comprehensive review for four years. In the interim, a tremendous amount of new information, obtained using molecular, genetic, neurochemical, and nuclear scanning techniques, has substantiated the important roles of catecholamine systems in development, cardiovascular function, psychiatric disorders, neurodegenerative diseases, and metabolism. This volume, based on the Ninth International Catecholamine Symposium, will have a substantial and lasting impact on medical science.

Exposure to stressful life experiences can disrupt key regulatory systems in the body and contribute to a variety of negative health outcomes. This authoritative text takes a biopsychosocial approach to understanding the role of stress in alcohol use disorder, posttraumatic stress disorder, depression, cardiovascular disease, type 2 diabetes, cancer, and other chronic diseases. It presents cutting-edge knowledge about how stressors are conceptualized and measured; connections to disease processes; systemic racism as a significant, ongoing stressor for people of color; and factors that promote resilience. For each of the disorders discussed, proven and promising stress-targeted clinical interventions are reviewed. Student-friendly features include an end-of-book glossary and an extensive bibliography to facilitate in-depth study of selected topics of interest.