Robert P. Hasserjian – författare

Non-Neoplastic Disorders of Bone Marrow is devoted to the evaluation and interpretation of bone marrow and peripheral blood specimens where non-neoplastic disorders can often mimic malignant conditions. Because these processes frequently require the integration of subtle morphologic clues with the clinical context, this practical, morphologically-grounded resource focuses on the spectrum of acquired non-neoplastic processes, selected clonal conditions, and congenital disorders. The volume is organized by etiology—addressing autoimmune diseases, metabolic disorders, nutritional deficiencies, and the effects of toxins and medications—to facilitate linking specific pathologic findings to potential diagnoses. By emphasizing important morphologic, immunophenotypic, genetic, and clinical features, this Fascicle fills this gap for practicing pathologists and trainees by illustrating the distinct morphologic characteristics and practical approach to the broad spectrum of benign blood and bone marrow disorders.

This book focuses on hematopoietic and lymphoid neoplasms that initially present as peripheral blood abnormalities, with either cytopenias or elevated peripheral blood counts, as well as non-neoplastic conditions that may raise concern for a hematologic malignancy. The scope of the book includes myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), mixed myelodysplastic/myeloproliferative neoplasms (MDS/MPN), as well as lymphomas and lymphoid leukemias that typically present initially with peripheral blood abnormalities.  Within each category, a comprehensive list of differential diagnoses is discussed. For each disease entity, the reader is updated with new molecular genetic data, biomarkers, and recent applications of immunophenotyping, and how to incorporate the new information in disease diagnosis and classifications is illustrated, including the use of diagnostic algorithms where appropriate. The book employs the revised WHO Classification of Hematopoietic Neoplasmsfor all disease entities.   Diagnosis of Blood and Bone Marrow Disorders will serve as a very useful resource for pathologists, pathologists in training, hematologists and medical technologists who are involved in the clinical work-up of patients with bone marrow and blood neoplasms.  It will provide a practical and concise yet comprehensive review.

This book focuses on hematopoietic and lymphoid neoplasms that initially present as peripheral blood abnormalities, with either cytopenias or elevated peripheral blood counts, as well as non-neoplastic conditions that may raise concern for a hematologic malignancy. The scope of the book includes myelodysplastic syndromes (MDS), myeloproliferative neoplasms (MPN), mixed myelodysplastic/myeloproliferative neoplasms (MDS/MPN), as well as lymphomas and lymphoid leukemias that typically present initially with peripheral blood abnormalities.  Within each category, a comprehensive list of differential diagnoses is discussed. For each disease entity, the reader is updated with new molecular genetic data, biomarkers, and recent applications of immunophenotyping, and how to incorporate the new information in disease diagnosis and classifications is illustrated, including the use of diagnostic algorithms where appropriate. The book employs the revised WHO Classification of Hematopoietic Neoplasmsfor all disease entities.   Diagnosis of Blood and Bone Marrow Disorders will serve as a very useful resource for pathologists, pathologists in training, hematologists and medical technologists who are involved in the clinical work-up of patients with bone marrow and blood neoplasms.  It will provide a practical and concise yet comprehensive review.