Robert R. Alfano – författare

Neurophotonics and Biomedical Spectroscopy addresses the novel state-of-the-art work in non-invasive optical spectroscopic methods that detect the onset and progression of diseases and other conditions, including pre-malignancy, cancer, Alzheimer's disease, tissue and cell response to therapeutic intervention, unintended injury and laser energy deposition. The book then highlights research in neurophotonics that investigates single and multi-photon excitation optical signatures of normal/diseased nerve tissues and in the brain, providing a better understanding of the underlying biochemical and structural changes of tissues and cells that are responsible for the observed spectroscopic signatures.

Topics cover a wide array of well-established UV, visible, NIR and IR optical and spectroscopic techniques and novel approaches to diagnose tissue changes, including: label free in vivo and ex vivo fluorescence spectroscopy, Stoke shift spectroscopy, spectral imaging, Resonance Raman spectroscopy, multiphoton two Photon excitation, and more.

Photonics and nonlinear optics are important areas of science, engineering and technology. One of the most important ultrafast nonlinear optical processes is the supercontinuum (SC) – the production of intense white light pulses covering: uv, visible, NIR, MIR, and IR. It is produced using ultrashort laser pulses (ps/fs) to produce the ultrabroad band of frequencies. This book covers the fundamental principles and surveys research of current thinkers and experts in the field with updated references of the key breakthroughs over the past decade and a half. The application of SC are time-resolved pump-SC probe absorption and excitation spectroscopy for chemistry, biology and physics fundamental processes; optical coherence tomography; ultrashort pulse generation in femtosecond and attosecond regions; frequency clocks; phase stabilization; optical communication; atmospheric science; lightning control; optical medical imaging; biological cell imaging; and metrology standards.

The use of light for probing and imaging biomedical media is promising for the development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. The advent of ultrafast lasers has enabled applications of nonlinear optical processes, which allow deeper imaging in biological tissues with higher spatial resolution. This book provides an overview of emerging novel optical imaging techniques, Gaussian beam optics, light scattering, nonlinear optics, and nonlinear optical tomography of tissues and cells. It consists of pioneering works that employ different linear and nonlinear optical imaging techniques for deep tissue imaging, including the new applications of single- and multiphoton excitation fluorescence, Raman scattering, resonance Raman spectroscopy, second harmonic generation, stimulated Raman scattering gain and loss, coherent anti-Stokes Raman spectroscopy, and near-infrared and mid-infrared supercontinuum spectroscopy. The book is a comprehensive reference of emerging deep tissue imaging techniques for researchers and students working in various disciplines.

The use of light for probing and imaging biomedical media is promising for the development of safe, noninvasive, and inexpensive clinical imaging modalities with diagnostic ability. The advent of ultrafast lasers has enabled applications of nonlinear optical processes, which allow deeper imaging in biological tissues with higher spatial resolution. This book provides an overview of emerging novel optical imaging techniques, Gaussian beam optics, light scattering, nonlinear optics, and nonlinear optical tomography of tissues and cells. It consists of pioneering works that employ different linear and nonlinear optical imaging techniques for deep tissue imaging, including the new applications of single- and multiphoton excitation fluorescence, Raman scattering, resonance Raman spectroscopy, second harmonic generation, stimulated Raman scattering gain and loss, coherent anti-Stokes Raman spectroscopy, and near-infrared and mid-infrared supercontinuum spectroscopy. The book is a comprehensive reference of emerging deep tissue imaging techniques for researchers and students working in various disciplines.

This book, now in its fourth edition, is a well-known classic on the ultrafast nonlinear and linear processes responsible for supercontinuum generation. The book begins with chapters reviewing the experimental and theoretical understanding of the field along with key applications developed since the discovery of the supercontinuum effect. The chapters that follow cover recent research activity on supercontinuum phenomena, novel applications, and advances achieved since the publication of the previous edition. The new chapters focus on: filamentation in gases, air, and condensed media; conical emission by four-wave mixing and X-waves; electronic self-phase mechanism; higher harmonics generation;  attosecond laser pulses; complex vector beam supercontinuum; higher order self-phase modulation and cross-phase modulation; nonlinear supercontinuum interference in uniaxial crystals; new nonlinear microscopes involving supercontinuum and ultrafast lasers with biomedical applications; and other current supercontinuum applications in communications.

The Supercontinuum Laser Source is a definitive work by one of the discoverers of the white light effect. It is indispensable reading for any researcher or student working in the field of ultrafast laser physics.

Chapter 6 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.