Roberta Ward – författare
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2 produkter
2 produkter
Metal-based Neurodegeneration
From Molecular Mechanisms to Therapeutic Strategies
Inbunden, Engelska, 2005
1 706 kr
Tillfälligt slut
This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson’s disease, CJD and Huntington’s disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in these diseases. Looking at each specific neurological disorder in turn, the book outlines the role of metals in human biology, in particular in the brain and explores tools for testing potential therapeutic strategies. It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future.
Metal-Based Neurodegeneration
From Molecular Mechanisms to Therapeutic Strategies
Inbunden, Engelska, 2013
2 019 kr
Skickas inom 11-20 vardagar
Neurodegenerative diseases of the human brain appear in various forms, resulting in disorders of movement and coordination, cognitive deterioration and psychiatric disturbances. Many of the key factors leading to neurodegenerative diseases are similar, including the dysfunction of metal ion homeostasis, redox-active metal ions generating oxidative stress, and intracellular inclusion bodies.Metal-based Neurodegeneration presents a detailed survey of the molecular origins of neurodegenerative diseases. Each chapter is dedicated to a specific disease, presenting the latest scientific findings, including details of their biochemical actors (proteins or peptides), their normal and pathological conformations, and a description of the diseases characteristics, with an emphasis on the role of metal-induced oxidative stress, which can result in the production of intracellular aggregates of target proteins and peptides. Topics covered include: Brain function, physiology and the blood-brain barrierImmune system and neuroinflammationAging and mild cognitive impairment, MCIParkinson’s DiseaseAlzheimer’s DiseaseCreutzfelt-Jakob and related prion diseasesAlcoholic Brain DamageTherapeutic strategies to combat the onset and progression of neurological diseasesThis extensively updated, full colour, second edition of Metal-based Neurodegeneration is an essential text for research scientists and clinicians working in gerontology, neuropathology, neurochemistry, and metalloprotein mechanisms.