Rodrick Wallace - Böcker
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40 produkter
40 produkter
Politics, Hierarchy, and Public Health
Voting Patterns in the 2016 US Presidential Election
Inbunden, Engelska, 2019
2 166 kr
Skickas inom 10-15 vardagar
Steep socioeconomic hierarchy in post-industrial Western society threatens public health because of the physiological consequences of material and psychosocial insecurities and deprivations. Following on from their previous books, the authors continue their exploration of the geography of early mortality from age-related chronic conditions, of risk behaviors and their health outcomes, and of infant and child mortality, all due to rigid hierarchy. They divide the 50 states into those that gave their electoral college votes to Trump and those that gave theirs to Clinton in the 2016 presidential election and compare the two sets for socioeconomic and public health profiles. They deliberately apply only simple standard statistical methods in the public health analyses: t-test, Mann-Whitney test, bivariate regression, and backward stepwise multivariate regression. The book assumes familiarity with basic statistics.The authors argue that the unequal power relations that result in eroding public health in the nation and, in particular, in the Trump-voting states, largely cascade from the collapse of American industry, and they analyze the Cold War roots of that collapse. In two largely independent chapters on economics, they explore both the suppression of countervailing forces, such as organized labor, and the diversion of technical resources to the military as essential foundations to the population-level suffering that expressed itself in the 2016 presidential election.This interdisciplinary book has several primary audiences: creators of public policies, such as legislators and governmental staff, public health professionals and social epidemiologists, economists, labor union professionals, civil rights advocates, political scientists, historians, and students of these disciplines from public health through the social sciences.The Open Access version of this book, available at http://www.taylorfrancis.com, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 4.0 license.
Ecosystem Approach to Economic Stabilization
Escaping the Neoliberal Wilderness
Häftad, Engelska, 2020
634 kr
Skickas inom 10-15 vardagar
The creation of economic institutions that can function well under substantial uncertainties -- Black Swans -- is analogous to the dilemmas confronting our hunter-gatherer forefathers in the face of large-scale ecological unpredictability. The ultimate solution was not the development of a super hunter-gatherer technology that could ride out repeated catastrophe, but rather the invention, in neolithic times, of culturally-adapted 'farmed' ecosystems constructed to maximize food yield and minimize risks of famine. Recent advances in evolutionary and ecosystem theory applied to economic structure and process may permit construction of both new economic theory and new tools for data analysis that can help in the design of more robust economic institutions. This may result in less frequent and less disruptive transitions, and enable the design of culturally-specific systems less affected by those that do occur.This unique and innovative book applies cutting-edge methods from cognitive science and evolutionary theory to the problem of the necessary stabilization of economic processes. At the core of this book is the establishment of a statistics-like toolbox for the study of empirical data that is consistent with generalized evolutionary approaches. This toolbox enables the construction of both new economic theories and methods of data analysis that can help in the design of more robust economic institutions. This in turn will result in less frequent and less disruptive Black Swans, and enable as well the design of culturally-specific systems less affected by those that do occur.
Politics, Hierarchy, and Public Health
Voting Patterns in the 2016 US Presidential Election
Häftad, Engelska, 2021
662 kr
Skickas inom 10-15 vardagar
Steep socioeconomic hierarchy in post-industrial Western society threatens public health because of the physiological consequences of material and psychosocial insecurities and deprivations. Following on from their previous books, the authors continue their exploration of the geography of early mortality from age-related chronic conditions, of risk behaviors and their health outcomes, and of infant and child mortality, all due to rigid hierarchy. They divide the 50 states into those that gave their electoral college votes to Trump and those that gave theirs to Clinton in the 2016 presidential election and compare the two sets for socioeconomic and public health profiles. They deliberately apply only simple standard statistical methods in the public health analyses: t-test, Mann-Whitney test, bivariate regression, and backward stepwise multivariate regression. The book assumes familiarity with basic statistics.The authors argue that the unequal power relations that result in eroding public health in the nation and, in particular, in the Trump-voting states, largely cascade from the collapse of American industry, and they analyze the Cold War roots of that collapse. In two largely independent chapters on economics, they explore both the suppression of countervailing forces, such as organized labor, and the diversion of technical resources to the military as essential foundations to the population-level suffering that expressed itself in the 2016 presidential election.This interdisciplinary book has several primary audiences: creators of public policies, such as legislators and governmental staff, public health professionals and social epidemiologists, economists, labor union professionals, civil rights advocates, political scientists, historians, and students of these disciplines from public health through the social sciences.
Consciousness
A Mathematical Treatment of the Global Neuronal Workspace Model
Inbunden, Engelska, 2005
536 kr
Skickas inom 10-15 vardagar
This book is not an intellectual history or popular summary of recent work on consciousness in humans. Bernard Baars (1988), Edelman and Tononi (2000), and many others, have written such, and done it well indeed. This book, rather, brings the powerful analytic machinery of communication theory to bear on the Global Neuronal Workspace (GNW) model of consciousness which Baars introduced, and does so in a formal mathematical manner. It is not the first such attempt. The philospher Fred Dretske (1981), indep- dent of Baars, long ago outlined how information theory might illuminate the understanding of mind. Adapting his approach on the necessary conditions for mental process, we apply a previously-developed information theory analysis of interacting cognitive biological and social modules to Baars' GNW, which has become the principal candidate for a 'standard model' of consciousness. Invoking an obvious canonical homology with statistical physics, the method, when iterated in the spirit of the Hierarchical Linear Model of regression theory, generates a fluctuating dynamic threshold for consciousness which is similar to a tunable phase transition in a physical system. The phenomenon is, however, constrained to a manifold/atlas structure analogous to a retina; an adaptable Rate Distortion manifold, whose 'topology', in a large sense, reflects the hierarchy of embedding constraints acting on consciousness. This view greatly extends what Baars has characterized as 'contexts.
Collective Consciousness and Its Discontents:
Institutional distributed cognition, racial policy, and public health in the United States
Inbunden, Engelska, 2007
1 096 kr
Skickas inom 10-15 vardagar
An earlier book by Rodrick Wallace entitled Consciousness: A Mathematical Treatment of the Global Neuronal Workspace Model, introduced a formal information-theoretic approach to individual consciousness implementing approaches developed previously by the cognitive scientist Bernard Baars and the philosopher Fred Dretske.This book takes a more formal 'groupoid' perspective and generalizes the results of that book to processes of 'distributed cognition' characteristic of large institutions that can entertain several, sometimes many, simultaneous 'global workspaces' which must compete for resources while communicating and cooperating.Equivalence classes of 'states' produce a network of language-analogs characterizing interacting cognitive modules which entertain multiple workspaces. Equivalence classes of these language-analogs produce dynamical manifolds describing temporal processes carried out by multiple-workspace institutions.
1 096 kr
Skickas inom 10-15 vardagar
Farming Human Pathogens: Ecological Resilience and Evolutionary Process introduces a cutting-edge mathematical formalism based on the asymptotic limit theorems of information theory to describe how punctuated shifts in mesoscale ecosystems can entrain patterns of gene expression and organismal evolution. The authors apply the new formalism toward characterizing a number of infectious diseases that have evolved in response to the world as humans have made it. Many of the human pathogens that are emerging out from underneath epidemiological control are 'farmed' in the metaphorical sense, as the evolution of drug-resistant HIV makes clear, but also quite literally, as demonstrated by avian influenza's emergence from poultry farms in southern China. The most successful pathogens appear able to integrate selection pressures humans have imposed upon them from a variety of socioecological scales. The book also presents a related treatment of Eigen's Paradox and the RNA 'error catastrophe' that bedevils models of the origins of viruses and of biological life itself.
Ecosystem Approach to Economic Stabilization
Escaping the Neoliberal Wilderness
Inbunden, Engelska, 2015
2 236 kr
Skickas inom 10-15 vardagar
The creation of economic institutions that can function well under substantial uncertainties -- Black Swans -- is analogous to the dilemmas confronting our hunter-gatherer forefathers in the face of large-scale ecological unpredictability. The ultimate solution was not the development of a super hunter-gatherer technology that could ride out repeated catastrophe, but rather the invention, in neolithic times, of culturally-adapted 'farmed' ecosystems constructed to maximize food yield and minimize risks of famine. Recent advances in evolutionary and ecosystem theory applied to economic structure and process may permit construction of both new economic theory and new tools for data analysis that can help in the design of more robust economic institutions. This may result in less frequent and less disruptive transitions, and enable the design of culturally-specific systems less affected by those that do occur.This unique and innovative book applies cutting-edge methods from cognitive science and evolutionary theory to the problem of the necessary stabilization of economic processes. At the core of this book is the establishment of a statistics-like toolbox for the study of empirical data that is consistent with generalized evolutionary approaches. This toolbox enables the construction of both new economic theories and methods of data analysis that can help in the design of more robust economic institutions. This in turn will result in less frequent and less disruptive Black Swans, and enable as well the design of culturally-specific systems less affected by those that do occur.
1 096 kr
Skickas inom 10-15 vardagar
Farming Human Pathogens: Ecological Resilience and Evolutionary Process introduces a cutting-edge mathematical formalism based on the asymptotic limit theorems of information theory to describe how punctuated shifts in mesoscale ecosystems can entrain patterns of gene expression and organismal evolution.
Collective Consciousness and Its Discontents:
Institutional distributed cognition, racial policy, and public health in the United States
Häftad, Engelska, 2010
1 096 kr
Skickas inom 10-15 vardagar
An earlier book by Rodrick Wallace entitled Consciousness: A Mathematical Treatment of the Global Neuronal Workspace Model, introduced a formal information-theoretic approach to individual consciousness implementing approaches developed previously by the cognitive scientist Bernard Baars and the philosopher Fred Dretske.This book takes a more formal 'groupoid' perspective and generalizes the results of that book to processes of 'distributed cognition' characteristic of large institutions that can entertain several, sometimes many, simultaneous 'global workspaces' which must compete for resources while communicating and cooperating.Equivalence classes of 'states' produce a network of language-analogs characterizing interacting cognitive modules which entertain multiple workspaces. Equivalence classes of these language-analogs produce dynamical manifolds describing temporal processes carried out by multiple-workspace institutions.
2 392 kr
Skickas inom 10-15 vardagar
Gene Expression and its Discontents examines a class of probability models describing how epigenetic context affects gene expression and organismal development, using the asymptotic limit theorems of information theory in a highly formal manner. Taking classic results on spontaneous symmetry breaking abducted from statistical physics in groupoid, rather than group, circumstances, the work suggests that epigenetic information sources act as analogs to a tunable catalyst, directing development into different characteristic pathways according to the structure of external signals. The results have significant implications for epigenetic epidemiology, in particular for understanding how environmental stressors, in a large sense, can induce a broad spectrum of developmental disorders in humans. The authors then apply the perspective to a number of chronic diseases broadly associated with obesity, using data at different scales of observation.
536 kr
Skickas inom 10-15 vardagar
This book is not an intellectual history or popular summary of recent work on consciousness in humans. Bernard Baars (1988), Edelman and Tononi (2000), and many others, have written such, and done it well indeed. This book, rather, brings the powerful analytic machinery of communication theory to bear on the Global Neuronal Workspace (GNW) model of consciousness which Baars introduced, and does so in a formal mathematical manner. It is not the first such attempt. The philospher Fred Dretske (1981), indep- dent of Baars, long ago outlined how information theory might illuminate the understanding of mind. Adapting his approach on the necessary conditions for mental process, we apply a previously-developed information theory analysis of interacting cognitive biological and social modules to Baars' GNW, which has become the principal candidate for a 'standard model' of consciousness. Invoking an obvious canonical homology with statistical physics, the method, when iterated in the spirit of the Hierarchical Linear Model of regression theory, generates a fluctuating dynamic threshold for consciousness which is similar to a tunable phase transition in a physical system. The phenomenon is, however, constrained to a manifold/atlas structure analogous to a retina; an adaptable Rate Distortion manifold, whose 'topology', in a large sense, reflects the hierarchy of embedding constraints acting on consciousness. This view greatly extends what Baars has characterized as 'contexts.
Mathematical Approach To Multilevel, Multiscale Health Interventions, A: Pharmaceutical Industry Decline And Policy Response
Inbunden, Engelska, 2013
1 467 kr
Skickas inom 5-8 vardagar
This book, based on published studies, takes a unique perspective on the 30-year collapse of pharmaceutical industry productivity in the search for small molecule “magic bullet” interventions. The relentless escalation of inflation-adjusted cost per approved medicine in the United States — from $200 million in 1950 to $1.2 billion in 2010 — has driven industry giants to, at best, slavish imitation in drug design, and at worst, abandonment of research and embracing of widespread fraud in consumer marketing.The book adapts formalism across a number of disciplines to the strategy for design of mutilevel interventions, focusing first on molecular, cellular, and larger scale examples, and then extending the argument to the simplifications provided by the dominant role of social and cultural structures and processes in individual and population patterns of health and illness.In place of “magic bullets”, we must now apply “magic strategies” that act across both the scale and level of organization. This book provides an introductory roadmap to the new tools that will be needed for the design of such strategies.
Plague on Your Houses
How New York Was Burned Down and National Public Health Crumbled
Häftad, Engelska, 2001
314 kr
Skickas inom 3-6 vardagar
A Plague on Your Houses is a scorching indictment of the decision to close fire companies in New York in the 1970s and a frightening study of the way misguided and malevolent social policy can spark a chain reaction of enormous and unforeseen urban collapse.
Clear-Cutting Disease Control
Capital-Led Deforestation, Public Health Austerity, and Vector-Borne Infection
Häftad, Engelska, 2019
519 kr
Skickas inom 10-15 vardagar
The vector-borne Zika virus joins avian influenza, Ebola, and yellow fever as recent public health crises threatening pandemicity.By a combination of stochastic modeling and economic geography, this book proposes two key causes together explain the explosive spread of the worst of the vector-borne outbreaks.Ecosystems in which such pathogens are largely controlled by environmental stochasticity are being drastically streamlined by both agribusiness-led deforestation and deficits in public health and environmental sanitation.Consequently, a subset of infections that once burned out relatively quickly in local forests are now propagating across susceptible human populations whose vulnerability to infection is often exacerbated in structurally adjusted cities. The resulting outbreaks are characterized by greater global extent, duration, and momentum.As infectious diseases in an age of nation states and global health programs cannot, as much of the present modeling literature presumes, be described by interacting populations of host, vector, and pathogen alone, a series of control theory models is also introduced here. These models, useful to researchers and health officials alike, explicitly address interactions between government ministries and the pathogens they aim to control.
Cognitive Dynamics on Clausewitz Landscapes
The Control and Directed Evolution of Organized Conflict
Inbunden, Engelska, 2019
536 kr
Skickas inom 10-15 vardagar
This book applies cutting-edge methods from cognitive and evolutionary theories to develop models of conflict between hierarchically-structured cognitive entities under circumstances of imprecision, uncertainty and stress.
Cognitive Dynamics on Clausewitz Landscapes
The Control and Directed Evolution of Organized Conflict
Häftad, Engelska, 2020
536 kr
Skickas inom 10-15 vardagar
This book applies cutting-edge methods from cognitive and evolutionary theories to develop models of conflict between hierarchically-structured cognitive entities under circumstances of imprecision, uncertainty and stress.
660 kr
Skickas inom 10-15 vardagar
This book is the first social epidemiological study of COVID-19 spread in New York City (NYC), the primary epicenter of the United States. New York City spread COVID-19 throughout the United States. The context of epicenter formation determined the rapid, extreme rise of NYC case and mortality rates. Decades of public policies destructive of poor neighborhoods of color heavily determined the spread within the City. Premature mortality rates revealed the "weathering" of policy-targeted communities: accelerated aging due to chronic stress. COVID attacks the elderly more severely than those under the age of 60. Communities with high proportions of prematurely aged residents proved fertile ground for COVID illness and mortality. The very public policies that created swaths of white wealth across much of Manhattan and parts of Brooklyn destroyed the human diversity needed to ride out crises.Topics covered within the chapters include:Premature Death Rate Geography in New York City: Implications for COVID-19NYC COVID Markers at the ZIP Code LevelProspero's New Castles: COVID Infection and Premature Mortality in the NY Metro RegionPandemic Firefighting vs. Pandemic Fire PreventionConclusion: Scales of Time in DisastersAn exemplary study in health disparities, COVID-19 in New York City: An Ecology of Race and Class Oppression is essential reading for social epidemiologists, public health researchers of health disparities, those in public service tasked with addressing these problems, and infectious disease scientists who focus on spread in human populations of new zoonotic diseases. The brief also should appeal to students in these fields, civil rights scholars, science writers, medical anthropologists and sociologists, medical and public health historians, public health economists, and public policy scientists.
Essays on Strategy and Public Health
The Systematic Reconfiguration of Power Relations
Inbunden, Engelska, 2022
1 531 kr
Skickas inom 10-15 vardagar
Taking a unique approach to public health tactics and strategy this volume will be of interest to social epidemiologists, public health economists, public policy scientists, as well as public health researchers and practitioners.
Essays on Strategy and Public Health
The Systematic Reconfiguration of Power Relations
Häftad, Engelska, 2023
1 531 kr
Skickas inom 10-15 vardagar
Taking a unique approach to public health tactics and strategy this volume will be of interest to social epidemiologists, public health economists, public policy scientists, as well as public health researchers and practitioners.
Consciousness, Cognition and Crosstalk: The Evolutionary Exaptation of Nonergodic Groupoid Symmetry-Breaking
Häftad, Engelska, 2021
694 kr
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This book makes application to the dynamics of arousal and distraction, and to other examples. A modified version of the Kadanoff picture of phase transitions in consciousness emerges from the Morse Function itself in a surprisingly standard manner, closely associated with the breaking of groupoid symmetries driven by fundamental equivalence class algebras. Although this is far indeed from the familiar world of physical theory, it should be possible, on the basis of the probability models developed in the book, to develop new statistical tools for the analysis of observational and empirical data regarding cognition and consciousness.
Recurrence of COVID-19 in New York State and New York City
Surfing the Second Wave
Häftad, Engelska, 2021
606 kr
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As a follow-up to COVID-19 in New York City: an Ecology of Race and Class Oppression, which showed that decades of discriminatory public policies shaped the Bronx into the epicenter of the first wave of COVID-19, this book examines the build up to the crest and subsequent ebbing of the second wave of COVID-19 across the 62 counties of New York State (NYS) and 152 ZIP Code areas of the four central boroughs of New York City (NYC). Like its predecessor, the sequel examines the vulnerabilities that give rise to spikes in infection rates that form epicenters. Unlike the first wave, NYC was not the epicenter of the second wave; high-incident counties just outside NYS formed an extended initial epicenter and exported COVID-19 to neighboring counties of NYS. Rural NYS counties differed significantly from urban ones socioeconomically and in infection rates during the cresting period. Before the crest, no socioeconomic factor was associated with county infection rates; rather, the major associating factor was political and cultural: percent of the 2020 vote garnered by Trump. Rural counties voted heavily for Trump. This association disappeared post-crest by mid-January 2021. In NYC, the Bronx again behaved like a single high-incidence entity, unlike the other three boroughs that had patches of high and low infection incidence. Among the topics covered:The Second COVID Wave Washes Over New York StateThe Second Wave Storm-Surges Across New York CityDiscussion of County Data from the Second Wave of COVID-19Parsing Meaning From the 152 ZIP Code Data The book closes with a prescription for pandemic response planning based on empowered communities and workers interacting with health departments as equals. The Recurrence of COVID-19 in New York State and New York City is a valuableresource for social epidemiologists, public health researchers of health disparities, those in public service tasked with addressing these problems, and infectious disease scientists who focus on spread in human populations of new zoonotic diseases. The brief also will find readership among students in these fields, civil rights scholars, science writers, medical anthropologists and sociologists, medical and public health historians, public health economists, and public policy scientists.
Deception and Delay in Organized Conflict
Essays on the Mathematical Theory of Maskirovka
Häftad, Engelska, 2022
483 kr
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This book explores the role of deception, delay, and self-deception in the dynamics of organized conflict, taking a formal approach that hews closely to the asymptotic limit theorems of information and control theories.
536 kr
Skickas inom 7-10 vardagar
From the ‘punctuated equilibrium' of Eldrege and Gould, through Lewontin's ‘triple helix' and the various visions and revisions of the Extended Evolutionary Synthesis (EES) of Laland and others, both data and theory have demanded an opening-up of the 1950's Evolutionary Synthesis that so firmly wedded evolutionary theory to the mathematics of gene frequency analysis. It can, however, be argued that a single deep and comprehensive mathematical theory may simply not be possible for the almost infinite varieties of evolutionary process active at and across the full range of scales of biological, social, institutional, and cultural phenomena. Indeed, the case history of 'meme theory' should have raised a red flag that narrow gene-centered models of evolutionary process may indeed have serious limitations. What is attempted here is less grand, but still broader than a gene-centered analysis. Following the instruction of Maturana and Varela that all living systems are cognitive, in a certainsense, and that living as a process is a process of cognition, the asymptotic limit theorems of information and control theories that bound all cognition provide a basis for constructing an only modestly deep but wider-ranging series of probability models that might be converted into useful statistical tools for the analysis of observational and experimental data related to evolutionary process. The line of argument in this series of interrelated essays proves to be surprisingly direct.
634 kr
Skickas inom 5-8 vardagar
Del 72 - Studies in Applied Philosophy, Epistemology and Rational Ethics
Mathematical Essays on Embodied Cognition
Insights from Information and Control Theories
Inbunden, Engelska, 2025
1 698 kr
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This book provides a unique formal foundation for the development of statistical tools useful in the exploration of observational and experimental data related to embodied cognition.
1 698 kr
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This book applies the powerful asymptotic limit theorems of information and control theories to understanding the dynamics of dysfunction in cognitive cultural artifacts encompassing individual minds, small social groupings, institutions, machine systems, and their many critical composites. A particular focus is on attempts to build ‘intelligent machines’ that would supposedly rival or surpass human minds. All such efforts are blindsided by the reality that all such machines are cultural artifacts of those who build them, closely reflecting cultural priorities and blindness, and that intelligent entities lacking the feedback of high-speed embodiment must endure exaggerated levels of failure by fabulation and hallucination. A principal feature is the detailed working-out of many probability models that can serve as the foundation of statistical tools for the analysis of real-time, real-world data on cognitive failure across a broad range of modes, scales, and levels of organization.
Bounded Rationality and Its Discontents
Information and Control Theory Models of Cognitive Dysfunction
Inbunden, Engelska, 2026
1 564 kr
Kommande
This book views cognitive processes of bounded rationality at different scales and levels of organization as cultural artifacts, seen through the lens of the asymptotic limit theorems of information and control theories. The resulting probability models are novel, deep, and provide a route for the development of new statistical tools aimed at the address of real-world, real-time phenomena ranging across individual minds, institutions, newly-developed machine cognition, and their various composites. A central finding is that, for any and all cognitive systems, culture-bound syndromes of ‘psychopathology’ aren’t bugs, but arise as inherent features of real-world challenge. This book is intended both as a tutorial and a toolbox for scientifically literate students, researchers, and practitioners. Potential applications range across the study and remediation of individual mental disorders, failures of machine cognition, and institutional dysfunction. This book is of particular use to those tasked with the maintenance of public health, public order, and collective security.
552 kr
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This volume compiles five papers modeling the effects of neoliberal economics on the emergence of Ebola and its aftermath. Neoliberalism is currently the world’s primary economic philosophy. It centers international relations around globalizing laissez-faire economics for multinational companies, promoting free trade, deregulating economic markets, and shifting state expenditures in favor of private property. The multidisciplinary teams represented here place both Ebola Makona, the Zaire Ebola virus variant that has infected 28,000 in West Africa, and Ebola Reston, which is currently emerging in industrial hog farms in the Philippines and China, within a multi-plank modeling framework. Using a stochastic extinction model that one group spatializes, environmental stochasticity across the ecologies in which Ebola evolves is treated as an ecosystemic prophylaxis. An agroecological logic gate is developed for epidemic control. A Black-Scholes model explicitly links economic margins across agricultural systems to success in biocontrol. This new control theory is further developed around the data-rate and rate-distortion theorems, a turbulence model, and cognitive symmetry breaking. Lastly, a model of pandemic penetrance is used to explore the domino effects of serious outbreaks amplifying through the cascades of disasters that can follow deadly pandemics. All the models presented are contextualized by socioeonomic geographies specific to outbreak locales.Together the models suggest shifts in regional agroeconomics under the neoliberal doctrine, driving deforestation and monoculture production, destroying the ecosystemic “friction” with which local forests typically disrupt Ebola transmission. The resulting collapse in such an ecological function accelerates pathogen spillover and propagation across the remaining host populations. The failure on the part of current control efforts to assimilate such a structural context may render even an efficacious vaccine dysfunctional. The authors propose an alternate science of disease and an adjunct program of interventions useful to researchers and public health officials alike.
1 640 kr
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This book describes how epigenetic context, in a large sense, affects gene expression and the development of an organism, using the asymptotic limit theorems of information theory to construct statistical models useful in data analysis. The approach allows deep understanding of how embedding context affects development. We find that epigenetic information sources act as tunable catalysts, directing ontogeny into characteristic pathways, a perspective having important implications for epigenetic epidemiology. In sum, environmental stressors can induce a broad spectrum of developmental dysfunctions, and the book explores a number of pandemic chronic diseases, using U.S. data at different scales and levels of organization. In particular, we find the legacy of slavery has been grossly compounded by accelerating industrial decline and urban decay. Individual chapters are dedicated to obesity and its sequelae, coronary heart disease, cancer, mental disorders, autoimmune dysfunction, Alzheimer’s disease, and other conditions. Developmental disorders are driven by environmental factors channeled by historical trajectory and are unlikely to respond to medical interventions at the population level in the face of persistent individual and community stress. Drugs powerful enough to affect deleterious epigenetic programming will likely have side effects leading to shortened lifespan. Addressing chronic conditions and developmental disorders requires significant large-scale changes in public policy and resource allocation.
Computational Psychiatry
A Systems Biology Approach to the Epigenetics of Mental Disorders
Inbunden, Engelska, 2017
1 096 kr
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This book explores mental disorders from a uniquely evolutionary perspective. Although there have been many attempts to mathematically model neural processes and, to some extent, their dysfunction, there is very little literature that models mental function within a sociocultural, socioeconomic, and environmental context. Addressing this gap in the extant literature, this book explores essential aspects of mental disorders, recognizing the ubiquitous role played by the exaptation of crosstalk between cognitive modules at many different scales and levels of organization, the missing heritability of complex diseases, and cultural epigenetics. Further, it introduces readers to valuable control theory tools that permit the exploration of the environmental induction of neurodevelopmental disorders, as well as the study of the synergism between culture, psychopathology and sleep disorders, offering a distinctively unique resource.