This extensively expanded third edition offers a practical introduction to Bio Data Science. With a hands-on approach to learning, this book offers ample opportunities to practice:- Installing and utilizing Linux as a virtual machine or remotely- Processing bio data with the programming language AWK- Managing data with the relational database system MariaDB- Analyzing and visualizing data with R- Implementing good bioinformatics practices with Jupyter Notebook and GitHubThis book targets both students and professionals in the life sciences. While it is aimed at beginners, it also provides valuable tips and tricks for experienced researchers dealing with large datasets. Worked examples illustrate how to utilize various bioinformatics tools such as BLAST, Clustal, PLINK, IGV, SAMtools, BCFtools, Mason2, Minimap, NCBI Datasets, Velvet, Jmol, and more for:- Identifying bacterial proteins potentially associated with pathogenicity- Querying molecular structures for redox-regulated enzymes- Mapping and assembling real or simulated sequence reads- Identifying and mapping molecular structure mutations in viruses- Conducting genome-wide association studiesAll software tools and datasets mentioned are freely available, and all code is accessible as Jupyter Notebooks on GitHub. Drawing from the author's experiences and knowledge gained from both academia and industry, this book provides a practical and comprehensive approach to bioinformatics.

This extensively expanded third edition offers a practical introduction to Bio Data Science. With a hands-on approach to learning, this book offers ample opportunities to practice:- Installing and utilizing Linux as a virtual machine or remotely- Processing bio data with the programming language AWK- Managing data with the relational database system MariaDB- Analyzing and visualizing data with R- Implementing good bioinformatics practices with Jupyter Notebook and GitHubThis book targets both students and professionals in the life sciences. While it is aimed at beginners, it also provides valuable tips and tricks for experienced researchers dealing with large datasets. Worked examples illustrate how to utilize various bioinformatics tools such as BLAST, Clustal, PLINK, IGV, SAMtools, BCFtools, Mason2, Minimap, NCBI Datasets, Velvet, Jmol, and more for:- Identifying bacterial proteins potentially associated with pathogenicity- Querying molecular structures for redox-regulated enzymes- Mapping and assembling real or simulated sequence reads- Identifying and mapping molecular structure mutations in viruses- Conducting genome-wide association studiesAll software tools and datasets mentioned are freely available, and all code is accessible as Jupyter Notebooks on GitHub. Drawing from the author's experiences and knowledge gained from both academia and industry, this book provides a practical and comprehensive approach to bioinformatics.

Wie weit darf oder muss der Einsatz von Gentechnik gehen? Angesichts von Klimakrisen und dem Rückgang der biologischen Vielfalt müssen wir differenzierter auf neue Techniken schauen. Viele sagen, dass dies die Aufgabe der Experten sei, doch mit der Entdeckung der Genschere CRISPR/Cas rückt die Gentechnik in den Entscheidungsalltag eines jeden Einzelnen. Diagnostik, Kinderwunsch, Gentherapie? Innerhalb des gesetzlichen Rahmens muss diese Entscheidungen jeder selbst treffen. Röbbe Wünschiers bietet Ihnen mit seinem Buch "Allgemeinbildung Gene, Genetik und Gentechnik für Dummies" eine neutrale Einführung in die Gentechnik und deren Bedeutung für Ihren Lebensalltag. Die Debatte um die Anwendung der Gentechnik spaltet die Gesellschaft, doch die Wichtigkeit dieser Debatte ist unumgänglich. Lernen Sie mehr über dieses spannende Thema und bilden Sie sich eine eigene Meinung.

Dieses essential soll als Einführung für eine zeitgemäße öffentliche Diskussion zur Gentechnologie dienen. Die Gentechnik betrifft uns alle in vielen Bereichen und wir müssen uns trauen, bunter und weiter zu denken. Tatsächlich kann bereits das komplette Erbgut von Viren und Bakterien chemisch erzeugt und „zum Leben erweckt“ werden. Mit der Genchirurgie ist die Medizin an einem Scheidepunkt: Wollen wir Erbkrankheiten therapieren oder genetisch „reparieren“? Und die Analyse tausender menschlicher Erbgute fördert Informationen zutage, die mit komplexen Krankheiten, aber auch Merkmalen wie Intelligenz in Verbindung stehen. Wie sollen wir dieses Wissen nutzen? Es stellt sich kaum noch die Frage, ob wir Gentechnik wollen, sondern vielmehr, wie wir sie anwenden.

This essential should serve as an introduction for a contemporary public discussion on genetic engineering. Genetic engineering affects us all in many areas and we must dare to think more colorful and further. In fact, the complete genetic material of viruses and bacteria can already be chemically produced and "brought to life". With genetic surgery, medicine is at a crossroads: do we want to treat hereditary diseases or "repair" them genetically? And the analysis of thousands of human genetic material reveals information that is related to complex diseases, but also to characteristics such as intelligence. How should we use this knowledge? The question is hardly whether we want genetic engineering, but rather how we use it.This Springer essential is a translation of the original German 1st edition essentials, Gentechnik by Röbbe Wünschiers, published by The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.

With CRISPR/Cas gene editing tools in hand, we are currently experiencing a new dimension in genetic engineering. But where should the journey lead?  Should we treat diseases or better repair them genetically? Will the new genetic engineering, combined with modern reproductive biology, lead to designer babies? And: May we allow a liberalization of these techniques as citizen science? New methods can precisely alter the genetic material - and they leave no traces. This gene and genome surgery thrives on increasing knowledge about the mode of action of genes, those trait-giving regions in the genome. This knowledge is being applied in practice, particularly in the breeding of more resistant and higher-yielding crops. And what about us? The author shows that gene variants have long been associated not only with diseases, but also with nutritional preferences or intelligence. Therapeutic and optimization options are close at hand. What effect does the environment have on the expression of genetic material? Genes can be shaped during a person's lifetime by the environment, nutrition or experiences and thus passed on to their offspring in a modified form. So, does society have a new form of long-term responsibility for (epi)genetic integrity?In this vividly and comprehensibly written book, the author explains the state of genetic engineering without assuming too much prior knowledge and invites an open dialogue on this ambivalent topic. Get your own idea of the fascinating yet intimidating possibilities of genetic engineering. Where do you stand on the issue? With the help of this book, you have the chance to form a differentiated opinion. This book is a translation of the original German 1st edition Generation Gen-Schere by Röbbe Wünschiers, published by Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). The text was subsequently revised by the author. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.

Durch die Genomeditierung mit der Genschere CRISPR/Cas und den Einsatz künstlicher Intelligenz bei der Analyse genetischer Daten erleben wir eine neue Dimension der Gentechnik. Wir sind die Generation mit der Genschere. Die Ergebnisse reichen von blutdrucksenkenden Tomaten und Gentherapien gegen Krebs über die Schaffung bakterieller Chassis als molekulare Werkstätten bis hin zur Wiedergeburt des ausgestorbenen Schattenwolfs und der ersten (Er)Zeugung von Designer-Babys.Wie weit dürfen wir gehen? Gehört unsere Zukunft der Genomarchitektur? Brauchen wir Gentechnik, um den Herausforderungen des Klimawandels zu begegnen? Rettet uns künstliche Intelligenz vor einer genetischen Datenflut – oder macht sie Gesundheit und Therapie zu einer unverständlichen Blackbox?Neue genomische Techniken ermöglichen präzise Eingriffe in das Erbgut – ganz ohne erkennbare Spuren. Sie basieren auf unserem wachsenden Verständnis von Genen, deren Bausteinen, epigenetischen Faktoren und Funktionen. Besonders in der Pflanzenzüchtung finden sie zunehmend Anwendung.Dieses Buch vermittelt anschaulich und verständlich die Entwicklung der modernen Gentechnologie. Es lädt dazu ein, ethische, gesellschaftliche und rechtliche Fragen zu diskutieren.Neu in dieser Auflage: Das Kapitel Gene und Gesetze beleuchtet die rechtlichen Rahmenbedingungen der Gentechnik in Züchtung und Medizin. Das Thema künstliche Intelligenz wurde erweitert, andere Kapitel wurden aktualisiert.

This extensively expanded third edition offers a practical introduction to Bio Data Science. With a hands-on approach to learning, this book offers ample opportunities to practice:- Installing and utilizing Linux as a virtual machine or remotely- Processing bio data with the programming language AWK- Managing data with the relational database system MariaDB- Analyzing and visualizing data with R- Implementing good bioinformatics practices with Jupyter Notebook and GitHubThis book targets both students and professionals in the life sciences. While it is aimed at beginners, it also provides valuable tips and tricks for experienced researchers dealing with large datasets. Worked examples illustrate how to utilize various bioinformatics tools such as BLAST, Clustal, PLINK, IGV, SAMtools, BCFtools, Mason2, Minimap, NCBI Datasets, Velvet, Jmol, and more for:- Identifying bacterial proteins potentially associated with pathogenicity- Querying molecular structures for redox-regulated enzymes- Mapping and assembling real or simulated sequence reads- Identifying and mapping molecular structure mutations in viruses- Conducting genome-wide association studiesAll software tools and datasets mentioned are freely available, and all code is accessible as Jupyter Notebooks on GitHub. Drawing from the author's experiences and knowledge gained from both academia and industry, this book provides a practical and comprehensive approach to bioinformatics.

This extensively expanded third edition offers a practical introduction to Bio Data Science. With a hands-on approach to learning, this book offers ample opportunities to practice:- Installing and utilizing Linux as a virtual machine or remotely- Processing bio data with the programming language AWK- Managing data with the relational database system MariaDB- Analyzing and visualizing data with R- Implementing good bioinformatics practices with Jupyter Notebook and GitHubThis book targets both students and professionals in the life sciences. While it is aimed at beginners, it also provides valuable tips and tricks for experienced researchers dealing with large datasets. Worked examples illustrate how to utilize various bioinformatics tools such as BLAST, Clustal, PLINK, IGV, SAMtools, BCFtools, Mason2, Minimap, NCBI Datasets, Velvet, Jmol, and more for:- Identifying bacterial proteins potentially associated with pathogenicity- Querying molecular structures for redox-regulated enzymes- Mapping and assembling real or simulated sequence reads- Identifying and mapping molecular structure mutations in viruses- Conducting genome-wide association studiesAll software tools and datasets mentioned are freely available, and all code is accessible as Jupyter Notebooks on GitHub. Drawing from the author's experiences and knowledge gained from both academia and industry, this book provides a practical and comprehensive approach to bioinformatics.

Wie weit darf oder muss der Einsatz von Gentechnik gehen? Angesichts von Klimakrisen und dem Rückgang der biologischen Vielfalt müssen wir differenzierter auf neue Techniken schauen. Viele sagen, dass dies die Aufgabe der Experten sei, doch mit der Entdeckung der Genschere CRISPR/Cas rückt die Gentechnik in den Entscheidungsalltag eines jeden Einzelnen. Diagnostik, Kinderwunsch, Gentherapie? Innerhalb des gesetzlichen Rahmens muss diese Entscheidungen jeder selbst treffen. Röbbe Wünschiers bietet Ihnen mit seinem Buch "Allgemeinbildung Gene, Genetik und Gentechnik für Dummies" eine neutrale Einführung in die Gentechnik und deren Bedeutung für Ihren Lebensalltag. Die Debatte um die Anwendung der Gentechnik spaltet die Gesellschaft, doch die Wichtigkeit dieser Debatte ist unumgänglich. Lernen Sie mehr über dieses spannende Thema und bilden Sie sich eine eigene Meinung.

Dieses essential soll als Einführung für eine zeitgemäße öffentliche Diskussion zur Gentechnologie dienen. Die Gentechnik betrifft uns alle in vielen Bereichen und wir müssen uns trauen, bunter und weiter zu denken. Tatsächlich kann bereits das komplette Erbgut von Viren und Bakterien chemisch erzeugt und „zum Leben erweckt“ werden. Mit der Genchirurgie ist die Medizin an einem Scheidepunkt: Wollen wir Erbkrankheiten therapieren oder genetisch „reparieren“? Und die Analyse tausender menschlicher Erbgute fördert Informationen zutage, die mit komplexen Krankheiten, aber auch Merkmalen wie Intelligenz in Verbindung stehen. Wie sollen wir dieses Wissen nutzen? Es stellt sich kaum noch die Frage, ob wir Gentechnik wollen, sondern vielmehr, wie wir sie anwenden.

This essential should serve as an introduction for a contemporary public discussion on genetic engineering. Genetic engineering affects us all in many areas and we must dare to think more colorful and further. In fact, the complete genetic material of viruses and bacteria can already be chemically produced and "brought to life". With genetic surgery, medicine is at a crossroads: do we want to treat hereditary diseases or "repair" them genetically? And the analysis of thousands of human genetic material reveals information that is related to complex diseases, but also to characteristics such as intelligence. How should we use this knowledge? The question is hardly whether we want genetic engineering, but rather how we use it.This Springer essential is a translation of the original German 1st edition essentials, Gentechnik by Röbbe Wünschiers, published by The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). A subsequent human revision was done primarily in terms of content, so that the book will read stylistically differently from a conventional translation. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.

With CRISPR/Cas gene editing tools in hand, we are currently experiencing a new dimension in genetic engineering. But where should the journey lead?  Should we treat diseases or better repair them genetically? Will the new genetic engineering, combined with modern reproductive biology, lead to designer babies? And: May we allow a liberalization of these techniques as citizen science? New methods can precisely alter the genetic material - and they leave no traces. This gene and genome surgery thrives on increasing knowledge about the mode of action of genes, those trait-giving regions in the genome. This knowledge is being applied in practice, particularly in the breeding of more resistant and higher-yielding crops. And what about us? The author shows that gene variants have long been associated not only with diseases, but also with nutritional preferences or intelligence. Therapeutic and optimization options are close at hand. What effect does the environment have on the expression of genetic material? Genes can be shaped during a person's lifetime by the environment, nutrition or experiences and thus passed on to their offspring in a modified form. So, does society have a new form of long-term responsibility for (epi)genetic integrity?In this vividly and comprehensibly written book, the author explains the state of genetic engineering without assuming too much prior knowledge and invites an open dialogue on this ambivalent topic. Get your own idea of the fascinating yet intimidating possibilities of genetic engineering. Where do you stand on the issue? With the help of this book, you have the chance to form a differentiated opinion. This book is a translation of the original German 1st edition Generation Gen-Schere by Röbbe Wünschiers, published by Springer Fachmedien Wiesbaden GmbH, part of Springer Nature in 2019. The translation was done with the help of artificial intelligence (machine translation by the service DeepL.com). The text was subsequently revised by the author. Springer Nature works continuously to further the development of tools for the production of books and on the related technologies to support the authors.

Durch die Genomeditierung mit der Genschere CRISPR/Cas und den Einsatz künstlicher Intelligenz bei der Analyse genetischer Daten erleben wir eine neue Dimension der Gentechnik. Wir sind die Generation mit der Genschere. Die Ergebnisse reichen von blutdrucksenkenden Tomaten und Gentherapien gegen Krebs über die Schaffung bakterieller Chassis als molekulare Werkstätten bis hin zur Wiedergeburt des ausgestorbenen Schattenwolfs und der ersten (Er)Zeugung von Designer-Babys.Wie weit dürfen wir gehen? Gehört unsere Zukunft der Genomarchitektur? Brauchen wir Gentechnik, um den Herausforderungen des Klimawandels zu begegnen? Rettet uns künstliche Intelligenz vor einer genetischen Datenflut – oder macht sie Gesundheit und Therapie zu einer unverständlichen Blackbox?Neue genomische Techniken ermöglichen präzise Eingriffe in das Erbgut – ganz ohne erkennbare Spuren. Sie basieren auf unserem wachsenden Verständnis von Genen, deren Bausteinen, epigenetischen Faktoren und Funktionen. Besonders in der Pflanzenzüchtung finden sie zunehmend Anwendung.Dieses Buch vermittelt anschaulich und verständlich die Entwicklung der modernen Gentechnologie. Es lädt dazu ein, ethische, gesellschaftliche und rechtliche Fragen zu diskutieren.Neu in dieser Auflage: Das Kapitel Gene und Gesetze beleuchtet die rechtlichen Rahmenbedingungen der Gentechnik in Züchtung und Medizin. Das Thema künstliche Intelligenz wurde erweitert, andere Kapitel wurden aktualisiert.