, Adrenal and Endocrine Tumors in Children' is the third volume in the series, 'Cancer Treatment and Research' devoted to pediatric oncology. Like its predecessors, it is organized into two sections. The first section again deals with issues of basic research germane to the understanding of childhood malignancies. In volume 3, the scope of the first section has been broadened to include a review that is epidemiologically oriented and a second review that is psychologically oriented. In the second part, major pediatric oncology units in Japan, Australia, Europe and the Americas have been invited to report their experience with of the multiple endocrine adrenal cortical carcinomas and the presentation neoplasia syndromes in children. In addition to these institutional reports of case material, there are reviews on genetics, pathology, and a diagnostic evaluation of children. The overview chapter on adrenal cortical carcinoma includes recommendations for radiotherapy from Dr. D' Angio and for che­ motherapy from Dr. Philip Schein. Individuals using these recommended therapies are encouraged to report their results to the editors. The informa­ tion will then be made available to others on request. List of Contributors ACTON, Dr. Ronald, Diabetes Research Hospital, Room 817, 1808 7th Ave. South, Birmingham, AL 35233, USA. BAUM, Edward S., M.D., Division of Hematology/Oncology, Northwestern University Medical School, Children's Memorial Hospital, 2300 Child­ ren's Plaza, Chicago, IL 60614, USA. BENZ, Dr. Chris c., Dept. of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

, Adrenal and Endocrine Tumors in Children'' is the third volume in the series, ''Cancer Treatment and Research'' devoted to pediatric oncology. Like its predecessors, it is organized into two sections. The first section again deals with issues of basic research germane to the understanding of childhood malignancies. In volume 3, the scope of the first section has been broadened to include a review that is epidemiologically oriented and a second review that is psychologically oriented. In the second part, major pediatric oncology units in Japan, Australia, Europe and the Americas have been invited to report their experience with of the multiple endocrine adrenal cortical carcinomas and the presentation neoplasia syndromes in children. In addition to these institutional reports of case material, there are reviews on genetics, pathology, and a diagnostic evaluation of children. The overview chapter on adrenal cortical carcinoma includes recommendations for radiotherapy from Dr. D'' Angio and for che­ motherapy from Dr. Philip Schein. Individuals using these recommended therapies are encouraged to report their results to the editors. The informa­ tion will then be made available to others on request. List of Contributors ACTON, Dr. Ronald, Diabetes Research Hospital, Room 817, 1808 7th Ave. South, Birmingham, AL 35233, USA. BAUM, Edward S., M.D., Division of Hematology/Oncology, Northwestern University Medical School, Children''s Memorial Hospital, 2300 Child­ ren''s Plaza, Chicago, IL 60614, USA. BENZ, Dr. Chris c., Dept. of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

, Adrenal and Endocrine Tumors in Children' is the third volume in the series, 'Cancer Treatment and Research' devoted to pediatric oncology. Like its predecessors, it is organized into two sections. The first section again deals with issues of basic research germane to the understanding of childhood malignancies. In volume 3, the scope of the first section has been broadened to include a review that is epidemiologically oriented and a second review that is psychologically oriented. In the second part, major pediatric oncology units in Japan, Australia, Europe and the Americas have been invited to report their experience with of the multiple endocrine adrenal cortical carcinomas and the presentation neoplasia syndromes in children. In addition to these institutional reports of case material, there are reviews on genetics, pathology, and a diagnostic evaluation of children. The overview chapter on adrenal cortical carcinoma includes recommendations for radiotherapy from Dr. D' Angio and for che­ motherapy from Dr. Philip Schein. Individuals using these recommended therapies are encouraged to report their results to the editors. The informa­ tion will then be made available to others on request. List of Contributors ACTON, Dr. Ronald, Diabetes Research Hospital, Room 817, 1808 7th Ave. South, Birmingham, AL 35233, USA. BAUM, Edward S., M.D., Division of Hematology/Oncology, Northwestern University Medical School, Children's Memorial Hospital, 2300 Child­ ren's Plaza, Chicago, IL 60614, USA. BENZ, Dr. Chris c., Dept. of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

The Second International Cell Culture Congress was structured as was the First Congress to bring together scientists from academia and industry to discuss the use of cell culture in support of bioscience. It was felt that a forum whereby state-of­ the-art presentations were followed by informal workshops would provide opportunity for the greatest exchange of information. Within the atmosphere of the workshop, problems common to basic as well as applied research were discussed and directions for the future were brought to light. These proceedings reflect and epitomize those discussions. Although it is difficult to cover all scientific disciplines utilizing cells in culture, we feel key areas were addressed at the Congress and are herein presented. Considerable emphasis has been given to the methods for establishing cells in culture and characterizing the cells once established as well as the improved technology for growing established cell lines. Examples of how recombinant DNA technology is being used to manipulate genes within mammalian cells, to clone mammalian genes and to insert them in prokaryotes has been included. Major emphasis has been given to the use of lymphocytes in culture for understanding immune responsiveness and the culturing of a variety of cell types as a means to understand disease states.

The Second International Cell Culture Congress was structured as was the First Congress to bring together scientists from academia and industry to discuss the use of cell culture in support of bioscience. It was felt that a forum whereby state-of­ the-art presentations were followed by informal workshops would provide opportunity for the greatest exchange of information. Within the atmosphere of the workshop, problems common to basic as well as applied research were discussed and directions for the future were brought to light. These proceedings reflect and epitomize those discussions. Although it is difficult to cover all scientific disciplines utilizing cells in culture, we feel key areas were addressed at the Congress and are herein presented. Considerable emphasis has been given to the methods for establishing cells in culture and characterizing the cells once established as well as the improved technology for growing established cell lines. Examples of how recombinant DNA technology is being used to manipulate genes within mammalian cells, to clone mammalian genes and to insert them in prokaryotes has been included. Major emphasis has been given to the use of lymphocytes in culture for understanding immune responsiveness and the culturing of a variety of cell types as a means to understand disease states.

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and pub­ lished symposium lectures are often the best overviews available. Unfortu­ nately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up-to-date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung can­ cer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and pub­ lished symposium lectures are often the best overviews available. Unfortu­ nately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up-to-date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung can­ cer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general onco­ logy textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals fre­ quently publish good indepth reviews of cancer topics, and published sympo­ sium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by divid­ ing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the Specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

, Adrenal and Endocrine Tumors in Children' is the third volume in the series, 'Cancer Treatment and Research' devoted to pediatric oncology. Like its predecessors, it is organized into two sections. The first section again deals with issues of basic research germane to the understanding of childhood malignancies. In volume 3, the scope of the first section has been broadened to include a review that is epidemiologically oriented and a second review that is psychologically oriented. In the second part, major pediatric oncology units in Japan, Australia, Europe and the Americas have been invited to report their experience with of the multiple endocrine adrenal cortical carcinomas and the presentation neoplasia syndromes in children. In addition to these institutional reports of case material, there are reviews on genetics, pathology, and a diagnostic evaluation of children. The overview chapter on adrenal cortical carcinoma includes recommendations for radiotherapy from Dr. D' Angio and for che­ motherapy from Dr. Philip Schein. Individuals using these recommended therapies are encouraged to report their results to the editors. The informa­ tion will then be made available to others on request. List of Contributors ACTON, Dr. Ronald, Diabetes Research Hospital, Room 817, 1808 7th Ave. South, Birmingham, AL 35233, USA. BAUM, Edward S., M.D., Division of Hematology/Oncology, Northwestern University Medical School, Children's Memorial Hospital, 2300 Child­ ren's Plaza, Chicago, IL 60614, USA. BENZ, Dr. Chris c., Dept. of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

, Adrenal and Endocrine Tumors in Children'' is the third volume in the series, ''Cancer Treatment and Research'' devoted to pediatric oncology. Like its predecessors, it is organized into two sections. The first section again deals with issues of basic research germane to the understanding of childhood malignancies. In volume 3, the scope of the first section has been broadened to include a review that is epidemiologically oriented and a second review that is psychologically oriented. In the second part, major pediatric oncology units in Japan, Australia, Europe and the Americas have been invited to report their experience with of the multiple endocrine adrenal cortical carcinomas and the presentation neoplasia syndromes in children. In addition to these institutional reports of case material, there are reviews on genetics, pathology, and a diagnostic evaluation of children. The overview chapter on adrenal cortical carcinoma includes recommendations for radiotherapy from Dr. D'' Angio and for che­ motherapy from Dr. Philip Schein. Individuals using these recommended therapies are encouraged to report their results to the editors. The informa­ tion will then be made available to others on request. List of Contributors ACTON, Dr. Ronald, Diabetes Research Hospital, Room 817, 1808 7th Ave. South, Birmingham, AL 35233, USA. BAUM, Edward S., M.D., Division of Hematology/Oncology, Northwestern University Medical School, Children''s Memorial Hospital, 2300 Child­ ren''s Plaza, Chicago, IL 60614, USA. BENZ, Dr. Chris c., Dept. of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

, Adrenal and Endocrine Tumors in Children' is the third volume in the series, 'Cancer Treatment and Research' devoted to pediatric oncology. Like its predecessors, it is organized into two sections. The first section again deals with issues of basic research germane to the understanding of childhood malignancies. In volume 3, the scope of the first section has been broadened to include a review that is epidemiologically oriented and a second review that is psychologically oriented. In the second part, major pediatric oncology units in Japan, Australia, Europe and the Americas have been invited to report their experience with of the multiple endocrine adrenal cortical carcinomas and the presentation neoplasia syndromes in children. In addition to these institutional reports of case material, there are reviews on genetics, pathology, and a diagnostic evaluation of children. The overview chapter on adrenal cortical carcinoma includes recommendations for radiotherapy from Dr. D' Angio and for che­ motherapy from Dr. Philip Schein. Individuals using these recommended therapies are encouraged to report their results to the editors. The informa­ tion will then be made available to others on request. List of Contributors ACTON, Dr. Ronald, Diabetes Research Hospital, Room 817, 1808 7th Ave. South, Birmingham, AL 35233, USA. BAUM, Edward S., M.D., Division of Hematology/Oncology, Northwestern University Medical School, Children's Memorial Hospital, 2300 Child­ ren's Plaza, Chicago, IL 60614, USA. BENZ, Dr. Chris c., Dept. of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.

The Second International Cell Culture Congress was structured as was the First Congress to bring together scientists from academia and industry to discuss the use of cell culture in support of bioscience. It was felt that a forum whereby state-of­ the-art presentations were followed by informal workshops would provide opportunity for the greatest exchange of information. Within the atmosphere of the workshop, problems common to basic as well as applied research were discussed and directions for the future were brought to light. These proceedings reflect and epitomize those discussions. Although it is difficult to cover all scientific disciplines utilizing cells in culture, we feel key areas were addressed at the Congress and are herein presented. Considerable emphasis has been given to the methods for establishing cells in culture and characterizing the cells once established as well as the improved technology for growing established cell lines. Examples of how recombinant DNA technology is being used to manipulate genes within mammalian cells, to clone mammalian genes and to insert them in prokaryotes has been included. Major emphasis has been given to the use of lymphocytes in culture for understanding immune responsiveness and the culturing of a variety of cell types as a means to understand disease states.

The Second International Cell Culture Congress was structured as was the First Congress to bring together scientists from academia and industry to discuss the use of cell culture in support of bioscience. It was felt that a forum whereby state-of­ the-art presentations were followed by informal workshops would provide opportunity for the greatest exchange of information. Within the atmosphere of the workshop, problems common to basic as well as applied research were discussed and directions for the future were brought to light. These proceedings reflect and epitomize those discussions. Although it is difficult to cover all scientific disciplines utilizing cells in culture, we feel key areas were addressed at the Congress and are herein presented. Considerable emphasis has been given to the methods for establishing cells in culture and characterizing the cells once established as well as the improved technology for growing established cell lines. Examples of how recombinant DNA technology is being used to manipulate genes within mammalian cells, to clone mammalian genes and to insert them in prokaryotes has been included. Major emphasis has been given to the use of lymphocytes in culture for understanding immune responsiveness and the culturing of a variety of cell types as a means to understand disease states.

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and pub­ lished symposium lectures are often the best overviews available. Unfortu­ nately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up-to-date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung can­ cer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and pub­ lished symposium lectures are often the best overviews available. Unfortu­ nately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up-to-date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung can­ cer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general onco­ logy textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals fre­ quently publish good indepth reviews of cancer topics, and published sympo­ sium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by divid­ ing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the Specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.