Recent Progress in Hormone Research, Volume 29 covers the proceedings of the 1972 Laurentian Hormone Conference held in Mont Tremblant, Province of Quebec, Canada, on August 27-September 1, 1972. The book discusses the studies on sex differentiation in mammals; male pseudohermaphroditism in the laboratory Norway rat; and androgen metabolism and mechanism of action in male pseudohermaphroditism. The text also describes the mechanism of initiation of parturition in the ewe; the neurovascular regulation of the anterior hypophysis; and microtubules and beta cell secretion. The role of microtubules and microfilaments in thyroid secretion; the functional and morphological alterations produced in target cells by anti-inflammatory steroids; and protein kinases are also considered. The book further tackles the role of phospholipids in hormone activation of adenylate cyclise; the chemistry of growth hormone and the lactogenic hormones; and hormonal regulation of gene expression in mammary cells. The text then encompasses the endocrine and metabolic effects of experimental obesity in human; the studies on luteinizing hormone and its subunits; and chemical studies of luteinizing hormone from human and ovine pituitaries. The studies on the structure and function of interstitial cell-stimulating hormone are also looked into.

Recent Progress in Hormone Research, Volume 30 presents the proceedings of the 1973 Laurentian Hormone Conference held at Mont Tremblant, Province of Quebec, Canada on August 26-31, 1973. The book presents papers on the regulation of the gonadotropins in primates, their neutralization by specific antibodies, and their role in oocyte maturation. The text also includes papers on the enzymatic interconversion of estrogens and on the concept of the mechanism of steroid hormone action. Papers on the thermogenic action of thyroid hormone related to active sodium transport are also considered. The book further tackles papers on the structure, heterogeneity, and activity of many of the lesser known hormones or hormone-like substances, such as the somatomedins A, B, and C, the epidermal growth factor, the insect hormones, parathyroid hormone, 1,25-dihydroxycholecalciferol, and prostaglandins. Endocrinologists and physiologists will find the text invaluable.

Recent Progress in Hormone Research, Volume 31 covers the proceedings of the 1974 Laurentian Hormone Conference held in Mount Tremblant, Quebec, Canada, on August 25-30, 1974. The book discusses the relationship between catecholamines and other hormones; the hormone receptor complexes and their modulation of membrane function; and receptors for insulin, NSILA-s, and growth hormone. The text also describes the mechanism of action of pituitary growth hormone; hormonal regulation of ovalbumin synthesis in the chick oviduct; and studies on the hepatic glucocorticoid receptor and on the hormonal modulation of specific mRNA levels during enzyme induction. The endocrine neurons; the formation of estrogens by central neuroendocrine tissues; and the operating characteristics of the hypothalamic-pituitary system during the menstrual cycle and observations of biological action of somatostatin are also considered. The book further tackles somatostatin; the relationship of sleep and sleep stages to neuroendocrine secretion and biological rhythms in human; and the genetic approaches to the study of the regulation and actions of vasopressin. The identification and actions of gastric inhibitory polypeptide; the studies on the pathogenesis of Graves'' ophthalmopathy, and qualitative and quantitative gonad-pituitary feedback is also looked into.

Recent Progress in Hormone Research, Volume 32 covers the proceedings of the 1975 Laurentian Hormone Conference. The book discusses genetic approaches to steroid hormone action; the cytochemical bioassay of hormones; and crystal structure of steroids. The text also describes the gonadotropin-releasing hormone and thyrotropin-releasing hormone; the ontogenesis of pituitary hormones and hypothalamic factors in the human fetus; and the etiologies of sexual maturation. The epidemiologic studies of diabetes in the Pima Indians; and the adrenal cortex and essential hypertension are also considered. The book further tackles the testicular control of follicle-stimulating hormone secretion; and nuclear receptors and the initiation of thyroid hormone action. The text then encompasses the receptor function and ion transport in turkey erythrocytes; the regulation of adenylate cyclase coupled beta-adrenergic receptors; and the control of cyclic AMP metabolism in parental and hybrid somatic cells. The molecular mechanisms of cyclic AMP action are also looked into. Endocrinologists, physiologists, molecular biologists, and biochemists will find the book invaluable.

Recent Progress in Hormone Research, Volume 33 covers the Proceedings of the 1976 Laurentian Hormone Conference. The book discusses the expanding significance of hypothalamic peptides; the LATS in Graves'' disease; and the ontogenesis of hypothalamic-pituitary-thyroid function and metabolism in human, sheep, and rat. The text also describes the antimullerian hormone; the evolution of gonadotropin structure and function; and the biosynthesis of parathyroid hormone. The carbon-13 nuclear magnetic resonance investigations of hormone structure and function; the regulation of vasopressin function in health and disease; and some considerations of the role of the antidiuretic hormone in water homeostasis are also considered. The book further tackles the clinical significance of circulating proinsulin and C-peptide; glucagon and the A cells; and a newly recognized pancreatic polypeptide. The text then encompasses the steroid hormone actions in tissue culture cells and cell hybrids and their relation to human malignancies; and the role of hormones on digestive and urinary tract carcinogenesis. Endocrinologists, neuroendocrinologists, and oncologists will find the book invaluable.

Recent Progress in Hormone Research presents the proceedings of the 1977 Laurentian Hormone Conference held at Mont Tremblant, Quebec, Canada from August 28 through September 2, 1977. The book discusses the concepts and perspectives of reproductive endocrinology; and the mechanism of action of hypothalamic hormones in the anterior pituitary gland and specific modulation of their activity by sex steroids and thyroid hormones. The text also describes the morphology of insulin secretion and binding; studies on relaxin; and the interrelationships between calcium, calcemic hormones and gastrointestinal hormones; and calcitonin binding sites in bone. The hormonal regulation of bone formation; neural control of ACTH; and the genetic regulation of mammalian glucuronidase are also considered. The book further tackles the crystal structure, molecular conformation, binding, and structure-function relationships of the thyroid hormone; the thyroxine transport proteins of plasma; and the pathways of metabolism of thyroid hormones. Endocrinologists, biochemists, and physiologists will find the text invaluable.

Recent Progress in Hormone Research, Volume 35 presents the proceedings of the 1978 Laurentian Hormone Conference held from August 27 through September 1, 1978 at the Mont Tremblant Lodge, Mont Tremblant, Quebec, Canada. The book discusses the organization, structure, transcription, and regulation of the ovalbumin gene; vitellogenesis as a versatile model for hormonal regulation of gene expression; and thyroid hormone receptors and responses. The text also describes the circular dichroism of pituitary hormones; receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex; and estrogen and antiestrogen action in reproductive tissues and tumors. The effects of FSH on gonadal functions; the hormonal control of ovarian follicular development; and studies on atherogenesis and corneal transplantation using cultured vascular and corneal endothelia are also considered. The book further tackles the testis-organizing H-Y antigen and the primary sex-determining mechanism of mammals; the studies of the 3T3-L1 adipocyte-like cell line; and the hormonal interactions in the regulation of blood glucose. Endocrinologists, physiologists, gynecologists, and cell biologists will find the text invaluable.

Recent Progress in Hormone Research, Volume 36 presents the proceedings of the 1979 Laurentian Hormone Conference. The book discusses seasonal breeding as nature''s contraceptive; the neuroendocrine control of the menstrual cycle; and the heterogeneity of estrogen binding sites. The text also describes steroid hormone receptors in breast cancer treatment strategy; the multihormonal regulation of casein gene expression at the transcriptional and posttranscriptional levels in the mammary gland; and the hormonal domains of response. The organization and evolution of cloned globin genes; the synthesis, cloning, and expression of hormone genes in Escherichia coli; and ACTH, beta-lipotropin, and related peptides in the brain, pituitary, and blood are also considered. The book further tackles cortoic acids; hormones controlling insect metamorphosis; and the early events in the biosynthesis of secretory and membrane proteins. The text also looks into autoimmunity in endocrine disease and the regulation of peptide hormone receptors and gonadal steroidogenesis. Endocrinologists, reproductive biologists, physiologists, and biochemists will find the book invaluable.

Recent Progress in Hormone Research, Volume 37 presents the proceedings of the 1980 Laurentian Hormone Conference held in Mont Tremblant Lodge on August 24-29, 1980. The book discusses the role of gonadal steroids in sexual differentiation; the regulation and function of the primate fetal adrenal gland and gonad; and an update of congenital adrenal hyperplasia. The text also describes the regulation of the mammalian corpus luteum; the mechanism of calcium action and release of vesicle-bound hormones during exocytosis; and the properties, intracellular localization, and multiple roles of calmodulin in cell regulation. The status of thymosin and other hormones of the thymus gland; the biosynthesis and mechanism of action of the nerve growth factor; and immunochemical studies relating to cholecystokinin in the brain and gut are also considered. The book further tackles the mechanism of insulin action; the intracellular receptors and internalization of polypeptide hormones; and studies on the structure and function of the chicken progesterone receptor. The text also looks into the role of guanine nucleotides in the regulation of adenylate cyclase activity; the nephrogenous cyclic AMP; and the neuroendocrine control of the menstrual cycle. Endocrinologists, physiologists, and biochemists will find the book invaluable.

Recent Progress in Hormone Research, Volume 38 presents the proceedings of the 1981 Laurentian Hormone Conference. The book presents papers on the preparation and properties of specific antibodies to receptor proteins; the effects of steroids on neural tissue and on patterns of behavior during development and in adult life; substance P and neurotensin; and the biological properties of the nuclear matrix. The text also includes papers on steroid hormone binding; the structure, expression, and evolution of growth hormone genes; glucocorticoid regulation of proopiomelanocortin gene expression in rodent pituitary; and molecular studies of genetic disorders affecting the expression of the human beta-globin gene. Papers on the role of nonsteroidal regulators in the control of oocyte and follicular maturation; insulin mediators and their control of metabolism through protein phosphorylation; the organization of the thyroid hormone receptor in chromatin; and the characteristics of the guanine nucleotide-binding regulatory component of adenylate cyclase are also encompassed. The book will prove invaluable to endocrinologists, biochemists, and scientists involved in hormone research.

Recent Progress in Hormone Research, Volume 39 presents the proceedings of the 1982 Laurentian Hormone Conference. The book presents papers on the ovarian triad of the primate menstrual cycle; the measurement of local glucose utilization and its use in localization of functional activity in the central nervous system of animals and human; and the impact of estrogens on hypothalamic nerve cells. The text also describes the biosynthesis, processing, and secretion of parathormone and secretory protein-1; gastrointestinal peptides; chemical and biological characterization of corticotropin releasing factor; and the regulation of kidney functions by hormones. Papers on calcitonin, prolactin, and growth hormone gene expression; the expression of cloned growth hormone and metallothionein genes in heterologous cells; and the actions of insulin on glucose transport and cAMP phosphodiesterase in fat cells are also encompassed. The book further tackles papers on hormone-induced morphogenesis and growth; and Leydig cell structure and steroidogenic function. Endocrinologists, physiologists, biochemists, and scientists involved in hormone research will prove the text invaluable.

Recent Progress in Hormone Research, Volume 40 presents the proceedings of the 1983 Laurentian Hormone Conference held in Mont Tremblant, Canada. The book presents papers on promoter elements of genes coding for proteins and modulation of transcription by estrogens and progesterone; the structure, expression, and evolution of the genes for the human glycoprotein hormones; and the regulation and organization of thyroid stimulating hormone genes. The text also includes papers on the mouse mammary tumor virus model in studies of glucocorticoid regulation; the role of the circadian system in reproductive phenomena; and endocytosis and membrane traffic in cultured cells. Other papers on neuroendocrinology, mechanism of hormone action, reproductive biology, subcellular processing of hormones and their receptors, hereditary resistance to 1,25-dihydroxyvitamin D are also encompassed. Physiologists, endocrinologists, biochemists, and scientists involved in hormone research will prove the book invaluable.

Recent Progress in Hormone Research, Volume 41 covers the proceedings of a Laurentian Hormone Conference held in late August 1984 at the Homestead in Hot Springs, Virginia. The book presents papers on the hormone-receptor interactions; the biosynthesis, secretion, metabolism, and mechanism of action of the steroid hormones; and the mechanisms of action of thyroid-stimulating hormone (TSH) and TRH. The text also includes papers on the molecular characterization of a brain specific mRNA; and the factors affecting changes in frequency and amplitude of GnRH pulses and the resulting functional consequences in various mammals including humans with disorders of fertility. Papers on the biological heritage of mammalian endocrinology, such as the actions of urotensin I in mammals and fishes; and the clinical implications of the glycosylation and posttranslational processing of the TSH are also encompassed. Endocrinologists, neuroscientists, biochemists, biophysicists, and scientists involved in hormone research will find the book invaluable.

Recent Progress in Hormone Research, Volume 29 covers the proceedings of the 1972 Laurentian Hormone Conference held in Mont Tremblant, Province of Quebec, Canada, on August 27-September 1, 1972. The book discusses the studies on sex differentiation in mammals; male pseudohermaphroditism in the laboratory Norway rat; and androgen metabolism and mechanism of action in male pseudohermaphroditism. The text also describes the mechanism of initiation of parturition in the ewe; the neurovascular regulation of the anterior hypophysis; and microtubules and beta cell secretion. The role of microtubules and microfilaments in thyroid secretion; the functional and morphological alterations produced in target cells by anti-inflammatory steroids; and protein kinases are also considered. The book further tackles the role of phospholipids in hormone activation of adenylate cyclise; the chemistry of growth hormone and the lactogenic hormones; and hormonal regulation of gene expression in mammary cells. The text then encompasses the endocrine and metabolic effects of experimental obesity in human; the studies on luteinizing hormone and its subunits; and chemical studies of luteinizing hormone from human and ovine pituitaries. The studies on the structure and function of interstitial cell-stimulating hormone are also looked into.

Recent Progress in Hormone Research, Volume 30 presents the proceedings of the 1973 Laurentian Hormone Conference held at Mont Tremblant, Province of Quebec, Canada on August 26-31, 1973. The book presents papers on the regulation of the gonadotropins in primates, their neutralization by specific antibodies, and their role in oocyte maturation. The text also includes papers on the enzymatic interconversion of estrogens and on the concept of the mechanism of steroid hormone action. Papers on the thermogenic action of thyroid hormone related to active sodium transport are also considered. The book further tackles papers on the structure, heterogeneity, and activity of many of the lesser known hormones or hormone-like substances, such as the somatomedins A, B, and C, the epidermal growth factor, the insect hormones, parathyroid hormone, 1,25-dihydroxycholecalciferol, and prostaglandins. Endocrinologists and physiologists will find the text invaluable.

Recent Progress in Hormone Research, Volume 31 covers the proceedings of the 1974 Laurentian Hormone Conference held in Mount Tremblant, Quebec, Canada, on August 25-30, 1974. The book discusses the relationship between catecholamines and other hormones; the hormone receptor complexes and their modulation of membrane function; and receptors for insulin, NSILA-s, and growth hormone. The text also describes the mechanism of action of pituitary growth hormone; hormonal regulation of ovalbumin synthesis in the chick oviduct; and studies on the hepatic glucocorticoid receptor and on the hormonal modulation of specific mRNA levels during enzyme induction. The endocrine neurons; the formation of estrogens by central neuroendocrine tissues; and the operating characteristics of the hypothalamic-pituitary system during the menstrual cycle and observations of biological action of somatostatin are also considered. The book further tackles somatostatin; the relationship of sleep and sleep stages to neuroendocrine secretion and biological rhythms in human; and the genetic approaches to the study of the regulation and actions of vasopressin. The identification and actions of gastric inhibitory polypeptide; the studies on the pathogenesis of Graves'' ophthalmopathy, and qualitative and quantitative gonad-pituitary feedback is also looked into.

Recent Progress in Hormone Research, Volume 32 covers the proceedings of the 1975 Laurentian Hormone Conference. The book discusses genetic approaches to steroid hormone action; the cytochemical bioassay of hormones; and crystal structure of steroids. The text also describes the gonadotropin-releasing hormone and thyrotropin-releasing hormone; the ontogenesis of pituitary hormones and hypothalamic factors in the human fetus; and the etiologies of sexual maturation. The epidemiologic studies of diabetes in the Pima Indians; and the adrenal cortex and essential hypertension are also considered. The book further tackles the testicular control of follicle-stimulating hormone secretion; and nuclear receptors and the initiation of thyroid hormone action. The text then encompasses the receptor function and ion transport in turkey erythrocytes; the regulation of adenylate cyclase coupled beta-adrenergic receptors; and the control of cyclic AMP metabolism in parental and hybrid somatic cells. The molecular mechanisms of cyclic AMP action are also looked into. Endocrinologists, physiologists, molecular biologists, and biochemists will find the book invaluable.

Recent Progress in Hormone Research, Volume 33 covers the Proceedings of the 1976 Laurentian Hormone Conference. The book discusses the expanding significance of hypothalamic peptides; the LATS in Graves'' disease; and the ontogenesis of hypothalamic-pituitary-thyroid function and metabolism in human, sheep, and rat. The text also describes the antimullerian hormone; the evolution of gonadotropin structure and function; and the biosynthesis of parathyroid hormone. The carbon-13 nuclear magnetic resonance investigations of hormone structure and function; the regulation of vasopressin function in health and disease; and some considerations of the role of the antidiuretic hormone in water homeostasis are also considered. The book further tackles the clinical significance of circulating proinsulin and C-peptide; glucagon and the A cells; and a newly recognized pancreatic polypeptide. The text then encompasses the steroid hormone actions in tissue culture cells and cell hybrids and their relation to human malignancies; and the role of hormones on digestive and urinary tract carcinogenesis. Endocrinologists, neuroendocrinologists, and oncologists will find the book invaluable.

Recent Progress in Hormone Research presents the proceedings of the 1977 Laurentian Hormone Conference held at Mont Tremblant, Quebec, Canada from August 28 through September 2, 1977. The book discusses the concepts and perspectives of reproductive endocrinology; and the mechanism of action of hypothalamic hormones in the anterior pituitary gland and specific modulation of their activity by sex steroids and thyroid hormones. The text also describes the morphology of insulin secretion and binding; studies on relaxin; and the interrelationships between calcium, calcemic hormones and gastrointestinal hormones; and calcitonin binding sites in bone. The hormonal regulation of bone formation; neural control of ACTH; and the genetic regulation of mammalian glucuronidase are also considered. The book further tackles the crystal structure, molecular conformation, binding, and structure-function relationships of the thyroid hormone; the thyroxine transport proteins of plasma; and the pathways of metabolism of thyroid hormones. Endocrinologists, biochemists, and physiologists will find the text invaluable.

Recent Progress in Hormone Research, Volume 35 presents the proceedings of the 1978 Laurentian Hormone Conference held from August 27 through September 1, 1978 at the Mont Tremblant Lodge, Mont Tremblant, Quebec, Canada. The book discusses the organization, structure, transcription, and regulation of the ovalbumin gene; vitellogenesis as a versatile model for hormonal regulation of gene expression; and thyroid hormone receptors and responses. The text also describes the circular dichroism of pituitary hormones; receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex; and estrogen and antiestrogen action in reproductive tissues and tumors. The effects of FSH on gonadal functions; the hormonal control of ovarian follicular development; and studies on atherogenesis and corneal transplantation using cultured vascular and corneal endothelia are also considered. The book further tackles the testis-organizing H-Y antigen and the primary sex-determining mechanism of mammals; the studies of the 3T3-L1 adipocyte-like cell line; and the hormonal interactions in the regulation of blood glucose. Endocrinologists, physiologists, gynecologists, and cell biologists will find the text invaluable.

Recent Progress in Hormone Research, Volume 36 presents the proceedings of the 1979 Laurentian Hormone Conference. The book discusses seasonal breeding as nature''s contraceptive; the neuroendocrine control of the menstrual cycle; and the heterogeneity of estrogen binding sites. The text also describes steroid hormone receptors in breast cancer treatment strategy; the multihormonal regulation of casein gene expression at the transcriptional and posttranscriptional levels in the mammary gland; and the hormonal domains of response. The organization and evolution of cloned globin genes; the synthesis, cloning, and expression of hormone genes in Escherichia coli; and ACTH, beta-lipotropin, and related peptides in the brain, pituitary, and blood are also considered. The book further tackles cortoic acids; hormones controlling insect metamorphosis; and the early events in the biosynthesis of secretory and membrane proteins. The text also looks into autoimmunity in endocrine disease and the regulation of peptide hormone receptors and gonadal steroidogenesis. Endocrinologists, reproductive biologists, physiologists, and biochemists will find the book invaluable.

Recent Progress in Hormone Research, Volume 37 presents the proceedings of the 1980 Laurentian Hormone Conference held in Mont Tremblant Lodge on August 24-29, 1980. The book discusses the role of gonadal steroids in sexual differentiation; the regulation and function of the primate fetal adrenal gland and gonad; and an update of congenital adrenal hyperplasia. The text also describes the regulation of the mammalian corpus luteum; the mechanism of calcium action and release of vesicle-bound hormones during exocytosis; and the properties, intracellular localization, and multiple roles of calmodulin in cell regulation. The status of thymosin and other hormones of the thymus gland; the biosynthesis and mechanism of action of the nerve growth factor; and immunochemical studies relating to cholecystokinin in the brain and gut are also considered. The book further tackles the mechanism of insulin action; the intracellular receptors and internalization of polypeptide hormones; and studies on the structure and function of the chicken progesterone receptor. The text also looks into the role of guanine nucleotides in the regulation of adenylate cyclase activity; the nephrogenous cyclic AMP; and the neuroendocrine control of the menstrual cycle. Endocrinologists, physiologists, and biochemists will find the book invaluable.

Recent Progress in Hormone Research, Volume 38 presents the proceedings of the 1981 Laurentian Hormone Conference. The book presents papers on the preparation and properties of specific antibodies to receptor proteins; the effects of steroids on neural tissue and on patterns of behavior during development and in adult life; substance P and neurotensin; and the biological properties of the nuclear matrix. The text also includes papers on steroid hormone binding; the structure, expression, and evolution of growth hormone genes; glucocorticoid regulation of proopiomelanocortin gene expression in rodent pituitary; and molecular studies of genetic disorders affecting the expression of the human beta-globin gene. Papers on the role of nonsteroidal regulators in the control of oocyte and follicular maturation; insulin mediators and their control of metabolism through protein phosphorylation; the organization of the thyroid hormone receptor in chromatin; and the characteristics of the guanine nucleotide-binding regulatory component of adenylate cyclase are also encompassed. The book will prove invaluable to endocrinologists, biochemists, and scientists involved in hormone research.

Recent Progress in Hormone Research, Volume 39 presents the proceedings of the 1982 Laurentian Hormone Conference. The book presents papers on the ovarian triad of the primate menstrual cycle; the measurement of local glucose utilization and its use in localization of functional activity in the central nervous system of animals and human; and the impact of estrogens on hypothalamic nerve cells. The text also describes the biosynthesis, processing, and secretion of parathormone and secretory protein-1; gastrointestinal peptides; chemical and biological characterization of corticotropin releasing factor; and the regulation of kidney functions by hormones. Papers on calcitonin, prolactin, and growth hormone gene expression; the expression of cloned growth hormone and metallothionein genes in heterologous cells; and the actions of insulin on glucose transport and cAMP phosphodiesterase in fat cells are also encompassed. The book further tackles papers on hormone-induced morphogenesis and growth; and Leydig cell structure and steroidogenic function. Endocrinologists, physiologists, biochemists, and scientists involved in hormone research will prove the text invaluable.

Recent Progress in Hormone Research, Volume 40 presents the proceedings of the 1983 Laurentian Hormone Conference held in Mont Tremblant, Canada. The book presents papers on promoter elements of genes coding for proteins and modulation of transcription by estrogens and progesterone; the structure, expression, and evolution of the genes for the human glycoprotein hormones; and the regulation and organization of thyroid stimulating hormone genes. The text also includes papers on the mouse mammary tumor virus model in studies of glucocorticoid regulation; the role of the circadian system in reproductive phenomena; and endocytosis and membrane traffic in cultured cells. Other papers on neuroendocrinology, mechanism of hormone action, reproductive biology, subcellular processing of hormones and their receptors, hereditary resistance to 1,25-dihydroxyvitamin D are also encompassed. Physiologists, endocrinologists, biochemists, and scientists involved in hormone research will prove the book invaluable.

Recent Progress in Hormone Research, Volume 41 covers the proceedings of a Laurentian Hormone Conference held in late August 1984 at the Homestead in Hot Springs, Virginia. The book presents papers on the hormone-receptor interactions; the biosynthesis, secretion, metabolism, and mechanism of action of the steroid hormones; and the mechanisms of action of thyroid-stimulating hormone (TSH) and TRH. The text also includes papers on the molecular characterization of a brain specific mRNA; and the factors affecting changes in frequency and amplitude of GnRH pulses and the resulting functional consequences in various mammals including humans with disorders of fertility. Papers on the biological heritage of mammalian endocrinology, such as the actions of urotensin I in mammals and fishes; and the clinical implications of the glycosylation and posttranslational processing of the TSH are also encompassed. Endocrinologists, neuroscientists, biochemists, biophysicists, and scientists involved in hormone research will find the book invaluable.