Rudy J. Castellani – författare
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3 produkter
3 produkter
Häftad, Engelska, 2025
1 829 kr
Skickas inom 10-15 vardagar
Neuropathology of Aging and Alzheimer’s Disease takes a foundational approach to the topic by offering basic scientific information and the latest advancements in the field. The focus of this reference is on neuropathology and recent advances in tissue characterization in aging, and in Alzheimer’s Disease. Neuropathology has direct relevance to therapeutic constructs and allows for an in-depth understanding of disease pathogenesis. It is a synthesis of the salient issues with respect to pathology, pathogenesis, diagnosis, disease, normal aging, biomarker relevance, and prospects for therapeutic intervention.
Detailed discussion and analysis of early Alzheimer’s disease investigators and their findingsDetailed discussion and analysis of the often-overlooked literature from the 1920’s to the 1960’sDetailed discussion and analysis of aging-related phenomena currently under studyDetailed discussion and analysis of punch-drunk syndrome and the transition to modern understanding of chronic traumatic encephalopathyDetailed discussion and analysis of the pathology of autosomal dominant Alzheimer’s disease and Alzheimer’s disease associated with Down syndromePractical issues with diagnosing and reporting Alzheimer’s disease and aging-related changes
E-bok
Engelska, 20252 247 kr
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Neuropathology of Aging and Alzheimer''s Disease takes a foundational approach to the topic by offering basic scientific information and the latest advancements in the field. The focus of this reference is on neuropathology and recent advances in tissue characterization in aging, and in Alzheimer''s Disease. Neuropathology has direct relevance to therapeutic constructs and allows for an in-depth understanding of disease pathogenesis. It is a synthesis of the salient issues with respect to pathology, pathogenesis, diagnosis, disease, normal aging, biomarker relevance, and prospects for therapeutic intervention.Detailed discussion and analysis of early Alzheimer''s disease investigators and their findingsDetailed discussion and analysis of the often-overlooked literature from the 1920''s to the 1960''sDetailed discussion and analysis of aging-related phenomena currently under studyDetailed discussion and analysis of punch-drunk syndrome and the transition to modern understanding of chronic traumatic encephalopathyDetailed discussion and analysis of the pathology of autosomal dominant Alzheimer''s disease and Alzheimer''s disease associated with Down syndromePractical issues with diagnosing and reporting Alzheimer''s disease and aging-related changes
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Holbourne’s theory that rotational head movement and shear strains were limiting factors in producing acute parenchymal brain damage was a watershed moment in understanding traumatic brain injury (TBI). Long term effects, and in particular neurodegenerative proteinopathy subsequent to TBI, remain theoretical, notwithstanding the poorly understood ‘punch drunk’ syndrome of the early and mid-20th century, and the 21st century concept of chronic traumatic encephalopathy.This book, the Handbook of Traumatic Brain Injury and Neurodegeneration, has as its theme the marriage between neurodegenerative disease and neurotrauma through TBI surrogates such as sport, military service, and experimental models, and the legitimacy of that marriage. In the 32 contributions included here, this handbook not only explores the deleterious effects of genuine TBI, but also, and more importantly, the relationship between TBI and neurodegeneration. Controversy notwithstanding, there is much to be learned about the biological effects of TBI, substrates for long-term sequelae, the relationship between TBI and diverse neuropsychiatric disorders, and targets for therapy. The overall message to the neuroscience community from these papers may be a cautionary tale. The null hypothesis, that there is no causal relationship between TBI and progressive neurodegenerative disease, appears to be very much in play, and the book will be of interest to all those working in the field.