Russell R. Lonser - Böcker

Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques.

Offers an up-to-date, comprehensive resource on drug delivery to the nervous system Provides a bridge for understanding across nervous system delivery-related physiology, drug delivery principles. and the methodologies that underlie the various methods of drug distribution (with clinical application) Written for a broad audience of researchers, clinicians and advanced graduate students in neuroscience, neurology, neurosurgery, pharmacology, radiology and psychiatry

Part of the Neurosurgery by Example series, this volume on surgical neuro-oncology presents exemplary cases in which renowned authors guide readers through the assessment and planning, decision making, surgical procedure, after care, and complication management of common and uncommon disorders. The cases explore a number of different types of nervous systems tumors, including glioblastoma, medulloblastoma, skull tumors, and more. Each chapter also contains 'pivot points' that illuminate changes required to manage patients in alternate or atypical situations, and pearls for accurate diagnosis, successful treatment, and effective complication management. Containing a focused review of medical evidence and expected outcomes, Surgical Neuro-Oncology is appropriate for neurosurgeons who wish to learn more about this subspecialty, and those preparing for the American Board of Neurological Surgery oral examination.

This issue of Neurosurgery Clinics focuses on Controversies in Spinal and Cranial Surgery. Article topics will include:Sacro-illiac Fusion; Interspinous Spacers;Bone Morphogenetic Protein, Platelet Concentrates and Other Biologics; MIS decompression; Pipeline flow diversion in subarachnoid hemorrhage; Direct versus indirect bypass for moyamoya disease; Management of prenatally diagnosed myelomeningocele; Management of incidental aneurysm; Surgical management of incidental low-grade glioma; and more!

This issue of Neurosurgery Clinics, edited by Drs.�Shahid Nimjee and Russell Lonser, will cover�Coagulation and Hematology in Neurological Surgery. Topics include�Biology of coagulation and coagulopathy; Evaluation of the coagulation in the neurosurgery patient;�Genetics of hyper- and hypo-coagulable states; Anticoagulants: pharmacokinetics, mechanisms of action and indications;�Use of antiplatelet agents in the neurosurgical patient;�Common conditions requiring long-term anti-coagulation in the neurosurgical patient;�Reversal of systemic and antiplatelet anticoagulants;�Intraoperative blood and factor replacement neurosurgery; Management of Intraoperative coagulopathy;�Deep vein thrombosis prophylaxis in the neurosurgical patient;�Postoperative anticoagulation after neurological surgery;�Management of venous sinus thrombosis;�Management of acute ischemic thrombosis; and Management of intracranial hemorrhage the anticoagulated patient.