Neurotransmitter changes taking place in the brain of patients with dementia disorders, mainly Alzheimer type dementia, are reported. Their role in the pathogenesis of Alzheimer's disease is discussed; and the neurochemical changes are considered as a base for formulating treatment strategies. By studying markers in the cerebrospinal fluid, diagnostic methods may be achieved that will aid in diagnosing subgroups of dememtia.

This book presents the results of a research project which has been carried out in the Special Research Unit (Sonderforschungs- bereich) 21 at Bonn University. It is a part of the current research on disaggregated econometric forecasting models with a fully integrated input-output system with variable input co- efficients where prices are explained as dual variables of the underlying production model. A similar approach has already been used by Knut KUbler "Ein disaggregiertes Prognosesystem fUr die Bundesrepublik, die Unternehmenssektoren", Meisenheim am Glan, 1977. But KUbler assumed Cobb-Douglas production functions. Mean- while a new approach has been suggested by Jorgenson and others, using more flexible forms of functions, e. g. the translog function as an approximation to any reasonable neo-classical production function, see Hudson and Jorgenson "US Energy Policy and Economic Growth, 1975 - 2000", Bell Journal of Economics and Management SCience, Vol. 5 (1974), page 461 ff. ~ Jorgenson and Fraumeni, "Substitution and Technical Change in Production", Discussion paper No. 752, Harvard Institute of Economic Research, Harvard University, Cambridge/Mass.(1 980) ~ Friede, "Investigation of Producer Behavior in the FRG using the Translog Price Function", Cambrigde/Mass. (1980). Krelle and Pallaschke "A General Demand System", Zeitschrift fUr Nationalokonomie 41 (1981), page 223 ff. suggested another approximation using a Taylor expansion of any reasonable demand system. Nakamura follows the lines of Jorgenson and his collaborators but extends them into new areas and reaches much better results.

Neurotransmitter changes taking place in the brain of patients with dementia disorders, mainly Alzheimer type dementia, are reported. Their role in the pathogenesis of Alzheimer's disease is discussed; and the neurochemical changes are considered as a base for formulating treatment strategies. By studying markers in the cerebrospinal fluid, diagnostic methods may be achieved that will aid in diagnosing subgroups of dememtia.

This book presents the results of a research project which has been carried out in the Special Research Unit (Sonderforschungs- bereich) 21 at Bonn University. It is a part of the current research on disaggregated econometric forecasting models with a fully integrated input-output system with variable input co- efficients where prices are explained as dual variables of the underlying production model. A similar approach has already been used by Knut KUbler "Ein disaggregiertes Prognosesystem fUr die Bundesrepublik, die Unternehmenssektoren", Meisenheim am Glan, 1977. But KUbler assumed Cobb-Douglas production functions. Mean- while a new approach has been suggested by Jorgenson and others, using more flexible forms of functions, e. g. the translog function as an approximation to any reasonable neo-classical production function, see Hudson and Jorgenson "US Energy Policy and Economic Growth, 1975 - 2000", Bell Journal of Economics and Management SCience, Vol. 5 (1974), page 461 ff. ~ Jorgenson and Fraumeni, "Substitution and Technical Change in Production", Discussion paper No. 752, Harvard Institute of Economic Research, Harvard University, Cambridge/Mass.(1 980) ~ Friede, "Investigation of Producer Behavior in the FRG using the Translog Price Function", Cambrigde/Mass. (1980). Krelle and Pallaschke "A General Demand System", Zeitschrift fUr Nationalokonomie 41 (1981), page 223 ff. suggested another approximation using a Taylor expansion of any reasonable demand system. Nakamura follows the lines of Jorgenson and his collaborators but extends them into new areas and reaches much better results.