Saheed Sabiu – författare

This book presents applications of metabolomics and integrated computational systems modeling in the bioprospecting of novel chemical entities (NCEs) and active pharmaceutical ingredients (APIs) from diverse natural sources. It bridges the gap between basic computational skills and advanced software development. The volume comprises original research articles, experimental protocols, case studies, and comprehensive reviews on computational approaches, including targeted and untargeted metabolomics, network pharmacology, molecular docking, density functional theory, and advanced molecular dynamics simulations, among others.An introduction to computational tools, algorithms, and databases relevant to systems biology and their applications in bioprospectionA discussion of advanced approaches for the discovery of new bioactive compounds and therapeutic agentsInsights into how systems biology simulations of cellular pathways can assist in identifying potential drug targets and bioactive compounds with precise therapeutic effectsReviews of strategic advances in the characterization and application of secondary metabolites derived from plants, microbes, animals, and endophytesMapping of unexplored target spaces for therapeutic bioprospectionThis book is intended for researchers and students in bioengineering, natural products development, phytopharmacology, plant biotechnology, drug discovery and development, phytotherapeutics, and metabolomics..

This reference work explores algae's role as one of the fastest-growing photosynthetic organisms with significant applications across various industries. Focusing on algae's secondary metabolites, this book offers evidence-based insights into algal research, emphasizing metabolism, cultivation, and the biological mechanisms of action of secondary metabolites in combating degenerative and microbial diseases such as diabetes, cancer, neurodegenerative disorders, and antimicrobial resistance. In this book, readers will gain a comprehensive understanding of how these photosynthetic organisms can be harnessed for diverse benefits.Divided into seven sections, the book begins with an overview of algae’s metabolism and cultivation techniques, followed by a comprehensive coverage of algae’s primary and secondary metabolites, their synthesis and pathways. Subsequent sections cover a wide range of topics including the biological mechanisms of action of algal metabolites against microbial resistance, and the nutritional, agricultural, environmental, and industrial advantages of algae. Contributions from renowned scholars and experts across disciplines such as biology, botany, biochemistry, biotechnology, and indigenous knowledge systems (IKS) enrich this work.Given its breadth, this book is a must-read for those interested in plant biotechnology, drug discovery and development, systems biology, and bioinformatics. It appeals to scholars, academics and professionals seeking to stay abreast of current trends and prospects within this dynamic area of research.