Saman Warnakulasuriya – författare

The book presents guides to the diagnosis and management of Oral Submucous Fibrosis, and includes a concise update on the recent evidence on aetiology and aetiopathogenesis to educate the reader on the prevention of the disease. Oral Submucous Fibrosis is a potentially malignant disorder that leads to the development of oral cancer. The first part of the book is dedicated to the epidemiology, the clinical features and the classification of Oral Submucous Fibrosis and associated conditions. The aetiology of Oral Submucous Fibrosis including lifestyle and genetic factors is discussed in the second part of the book followed by two chapters on the etiopathogenesis of the disease. Readers will find clear guidance on investigative techniques and the management of Oral Submucous Fibrosis. The last part of the book considers the connection between Areca nut and the disease and outlines methods of supporting areca nut chewers on habit cessation. The book is designed to serve as a comprehensive resource and reference in the oral health domain for learners at all levels, researchers, clinicians, and public health professionals. It will be of great value for students and trainees on any graduate program in dentistry.

This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine.

The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer.

Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and  their therapeutic applications for targeted therapies based on clinical trials reported worldwide.

This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.