Saman Warnakulasuriya – författare

This comprehensive multidisciplinary book examines all aspects of cancers of the mouth and oropharynx with the aim of equipping advanced students and practitioners in the early stages of specialist training with an up-to-date guide and reference. A multinational team of authors – all experts in the field of oral oncology – provide illuminating contributions on the full range of relevant topics: epidemiology, risk factors, clinical features, staging and prognostic factors, pathology, diagnostic techniques, disease prevention, surgery, radiotherapy, and chemotherapy. Molecular biology, molecular targeted therapies for advanced cases, and future diagnostic and prognostic applications of new technologies also receive careful attention. In providing a wealth of essential information and guidance in a practical format, the book will be a superb asset for senior graduate students in dentistry and specialist trainees in head and neck oncology. It will also be of high value for the many physicians, surgeons, pathologists, dentists, and specialists involved in the prevention, diagnosis, and management of squamous cell carcinomas of the oral cavity and oropharynx.

This comprehensive multidisciplinary book examines all aspects of cancers of the mouth and oropharynx with the aim of equipping advanced students and practitioners in the early stages of specialist training with an up-to-date guide and reference.

The book presents guides to the diagnosis and management of Oral Submucous Fibrosis, and includes a concise update on the recent evidence on aetiology and aetiopathogenesis to educate the reader on the prevention of the disease.

The book presents guides to the diagnosis and management of Oral Submucous Fibrosis, and includes a concise update on the recent evidence on aetiology and aetiopathogenesis to educate the reader on the prevention of the disease.

This is an innovative volume that introduces the emerging field of lifestyle dentistry, providing a current and relevant perspective on the strong connections between daily habits, lifestyles and oral health. Drawing on the expertise of over 60 international contributors from dentistry, medicine, public health, and behavioural science, this comprehensive resource features 26 evidence-based chapters that examine how lifestyle factors such as tobacco use, areca nut chewing, alcohol abuse, poor nutrition, sugar-rich diets, obesity, psychological stress, sleep disorders, eating disorders, recreational drug use, and risky sexual behaviours significantly impact oral health. It also addresses the two-way relationship between non-communicable diseases and oral health. Positioned at the intersection of behavioural science and oral medicine, the book provides oral healthcare professionals with a framework for understanding and addressing the multifactorial nature of oral disease. It also looks ahead to future opportunities, examining the potential of digital technologies to transform lifestyle interventions, patient engagement, and oral healthcare delivery.This previously unpublished topic addresses a significant gap in dental literature. It is essential reading for clinicians, educators, family practitioners, researchers, and students aiming to improve diagnostic insight, foster interdisciplinary collaboration, and adopt a holistic approach to oral care. It redefines oral healthcare as a key element of lifestyle medicine, enabling practitioners to promote both oral and overall health through informed, patient-centred strategies.

This book is a comprehensive overview of different forms of smokeless tobacco (ST) products consumed globally and their effect on periodontal health. It opens with the demographic descriptions of epidemiology of ST products availability and an analysis of global and regional trends in ST use. Following chapters provide a thorough review of existing literature on the impact of ST on periodontal tissues and peri-implant health. The book covers mechanisms of damage, investigating the biological mechanisms through which ST products cause damage and influence peri-implant conditions, as well as the clinical manifestations of ST on gingival inflammation and recession, attachment loss, alveolar bone resorption around teeth, tooth mobility and loss and peri-implant health post dental implant placement. The final chapter explores preventive strategies and habit interventions aimed at mitigating the adverse effects of smokeless tobacco on periodontal and peri-implant health. This book will be of great value for dental and oral health professionals including undergraduate and postgraduate dental students, general dentists, periodontists, oral medicine specialists, oral and maxillofacial surgeons, dental hygienists, and researchers in the field of oral health.

This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine.The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer.Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and  their therapeutic applications for targeted therapies based on clinical trials reported worldwide.This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.

This edited volume is about novel targeted therapies for the treatment of advanced neoplasms of the head and neck (HNSCC) with particular reference to oral squamous cell carcinomas and covers specific fields of cancer genetics and genomics for personalized medicine.The landmark studies from the HNSCC Cancer Genome Anatomy (TCGA) and the cancer Genome Atlas 2015 have revealed the multiplicity and diversity of genetic alterations in HNSCC. This remarkable body of information has elucidated novel druggable targets (eg. EGFR, mTOR, p53, survivin and aberrant microRNA) for therapeutic interventions in head and neck cancer.Readers will discover the importance of the biology and pathology of squamous cell carcinomas, the role of cancer stem cells and other factors that contribute to resistance to curative therapies such as hypoxia. We present an in-depth analysis of the HNSCC oncogenome describing the distinct molecular alterations in squamous cell carcinomas, which participate in specific molecular pathways whose dysregulation may contribute to most HNSCC cases. Final chapters of the book elucidate how these important cancer-driving molecular events and molecular pathways could be targeted to treat head and neck cancers and  their therapeutic applications for targeted therapies based on clinical trials reported worldwide.This book is aimed at a broad audience, including scientists, physicians, surgeons, and post graduate students engaged in oncology and provide the readers with an up-to-date, interdisciplinary knowledge and tools to better understand the evolving areas of targeted gene therapy and the key concept of personalized medicine in head and neck cancer.