Samik Basu – författare

Cellular Therapy for Autoimmune Disease provides a comprehensive exploration of the evolving landscape of cellular therapies for autoimmune diseases. The book delves into the evolution of the standard of care for autoimmune diseases, transitioning from chronic suppression to targeted replacement or suppression therapies. It covers a wide array of topics, including stem cell transplants, B-cell and plasma cell depletion strategies, and autologous regulatory and effector T-cell approaches. Additionally, it explores myeloid cellular approaches, allogeneic cellular therapies, and viral or nanoparticle-based strategies. Each chapter provides a thorough examination of mechanisms of action, clinical and non-clinical data, and the associated risks and benefits.Finally, the book addresses unique clinical and manufacturing considerations, offering a roadmap for the future state of cellular therapies in autoimmune diseases. This essential resource addresses the rapid advancements in cell therapies that have outpaced the availability of integrated, up-to-date resources. By bridging the gap between scientific research and clinical applications, it offers in-depth insights into mechanisms of action, disease-specific therapeutic strategies, and the latest innovations in clinical and manufacturing considerations for scientists and clinicians.Bridges the gap between scientific research and clinical applications for cellular therapies in autoimmune diseasesOffers in-depth insights into mechanisms of action and disease-specific therapeutic strategiesAddresses key clinical and manufacturing challenges for developing and implementing cell-based therapiesIntegrates the latest scientific discoveries and clinical breakthroughs for comprehensive understandingEquips professionals with practical knowledge to accelerate the translation of therapies into clinical practice

This book describes an approach for designing Systems-on-Chip such that the system meets precise mathematical requirements. The methodologies presented enable embedded systems designers to reuse intellectual property (IP) blocks from existing designs in an efficient, reliable manner, automatically generating correct SoCs from multiple, possibly mismatching, components.

This book describes an approach for designing Systems-on-Chip such that the system meets precise mathematical requirements. The methodologies presented enable embedded systems designers to reuse intellectual property (IP) blocks from existing designs in an efficient, reliable manner, automatically generating correct SoCs from multiple, possibly mismatching, components.

This book describes an approach for designing Systems-on-Chip such that the system meets precise mathematical requirements. The methodologies presented enable embedded systems designers to reuse intellectual property (IP) blocks from existing designs in an efficient, reliable manner, automatically generating correct SoCs from multiple, possibly mismatching, components.

This book provides a tutorial introduction to modern techniques for representing and reasoning about qualitative preferences with respect to a set of alternatives. The syntax and semantics of several languages for representing preference languages, including CP-nets, TCP-nets, CI-nets, and CP-theories, are reviewed. Some key problems in reasoning about preferences are introduced, including determining whether one alternative is preferred to another, or whether they are equivalent, with respect to a given set of preferences. These tasks can be reduced to model checking in temporal logic. Specifically, an induced preference graph that represents a given set of preferences can be efficiently encoded using a Kripke Structure for Computational Tree Logic (CTL). One can translate preference queries with respect to a set of preferences into an equivalent set of formulae in CTL, such that the CTL formula is satisfied whenever the preference query holds. This allows us to use a model checker toreason about preferences, i.e., answer preference queries, and to obtain a justification as to why a preference query is satisfied (or not) with respect to a set of preferences. This book defines the notions of the equivalence of two sets of preferences, including what it means for one set of preferences to subsume another, and shows how to answer preferential equivalence and subsumption queries using model checking. Furthermore, this book demontrates how to generate alternatives ordered by preference, along with providing ways to deal with inconsistent preference specifications. A description of CRISNER—an open source software implementation of the model checking approach to qualitative preference reasoning in CP-nets, TCP-nets, and CP-theories is included, as well as examples illustrating its use.

This book provides a tutorial introduction to modern techniques for representing and reasoning about qualitative preferences with respect to a set of alternatives. The syntax and semantics of several languages for representing preference languages, including CP-nets, TCP-nets, CI-nets, and CP-theories, are reviewed. Some key problems in reasoning about preferences are introduced, including determining whether one alternative is preferred to another, or whether they are equivalent, with respect to a given set of preferences. These tasks can be reduced to model checking in temporal logic. Specifically, an induced preference graph that represents a given set of preferences can be efficiently encoded using a Kripke Structure for Computational Tree Logic (CTL). One can translate preference queries with respect to a set of preferences into an equivalent set of formulae in CTL, such that the CTL formula is satisfied whenever the preference query holds. This allows us to use a model checker toreason about preferences, i.e., answer preference queries, and to obtain a justification as to why a preference query is satisfied (or not) with respect to a set of preferences. This book defines the notions of the equivalence of two sets of preferences, including what it means for one set of preferences to subsume another, and shows how to answer preferential equivalence and subsumption queries using model checking. Furthermore, this book demontrates how to generate alternatives ordered by preference, along with providing ways to deal with inconsistent preference specifications. A description of CRISNER—an open source software implementation of the model checking approach to qualitative preference reasoning in CP-nets, TCP-nets, and CP-theories is included, as well as examples illustrating its use.

This book constitutes the refereed proceedings of the 11th International Conference on Service-Oriented Computing, ICSOC 2012, held in Berlin, Germany, in December 2013. The 29 full papers and 27 short papers presented were carefully reviewed and selected from 205 submissions. The papers are organized in topical sections on service engineering, service operations and management; services in the cloud; and service applications and implementations.