Satinder Ahuja – författare

High pressure liquid chromatography–frequently called high performance liquid chromatography (HPLC or, LC) is the premier analytical technique in pharmaceutical analysis and is predominantly used in the pharmaceutical industry. Written by selected experts in their respective fields, the Handbook of Pharmaceutical Analysis by HPLC Volume 6, provides a complete yet concise reference guide for utilizing the versatility of HPLC in drug development and quality control. Highlighting novel approaches in HPLC and the latest developments in hyphenated techniques, the book captures the essence of major pharmaceutical applications (assays, stability testing, impurity testing, dissolution testing, cleaning validation, high-throughput screening).- A complete reference guide to HPLC- Describes best practices in HPLC and offers ''tricks of the trade'' in HPLC operation and method development- Reviews key HPLC pharmaceutical applications and highlights currents trends in HPLC ancillary techniques, sample preparations, and data handling

Modern Instrumental Analysis covers the fundamentals of instrumentation and provides a thorough review of the applications of this technique in the laboratory. It will serve as an educational tool as well as a first reference book for the practicing instrumental analyst. The text covers five major sections:1. Overview, Sampling, Evaluation of Physical Properties, and Thermal Analysis2. Spectroscopic Methods 3. Chromatographic Methods 4. Electrophoretic and Electrochemical Methods 5. Combination Methods, Unique Detectors, and Problem Solving Each section has a group of chapters covering important aspects of the titled subject, and each chapter includes applications that illustrate the use of the methods. The chapters also include an appropriate set of review questions.* Covers the fundamentals of instrumentation as well as key applications * Each chapter includes review questions that reinforce concepts * Serves as a quick reference and comprehensive guidebook for practitioners and students alike

This book describes the role modern pharmaceutical analysis plays in the development of new drugs. Detailed information is provided as to how the quality of drug products is assured from the point of discovery until the patient uses the drug. Coverage includes state-of-the-art topics such as analytics for combinatorial chemistry and high-throughput screening, formulation development, stability studies, international regulatory aspects and documentation, and future technologies that are likely to impact the field. Emphasis is placed on current, easy-to-follow methods that readers can apply in their laboratories.No book has effectively replaced the very popular text, Pharmaceutical Analysis, that was edited in the 1960s by Tak Higuchi. This book will fill that gap with an up-to-date treatment that is both handy and authoritative.

The basic objectives of this book are to: provide basic information on chromatography and separation science; show how simple extraction and partition processes provide the basis for development of chromatography and separation science; describe the role of chromatography and separation science in various fields; discuss the role of chromatography and separation science in development of new methodology; and present new evolving methods and how to select an optimum method.· The book covers the fundamental physical and chemical phenomena involved in separations· Provides a concise overview of the basics of transport phenomena and thermodynamics· Shows the importance of chromatography within separation science

The United States Food and Drug Administration (FDA) and other regulatory bodies around the world require that impurities in drug substance and drug product levels recommended by the International Conference on Harmonisation (ICH) be isolated and characterized. Identifying process-related impurities and degradation products also helps us to understand the production of impurities and assists in defining degradation mechanisms. When this process is performed at an early stage, there is ample time to address various aspects of drug development to prevent or control the production of impurities and degradation products well before the regulatory filing and thus assure production of a high-quality drug product.This book, therefore, has been designed to meet the need for a reference text on the complex process of isolation and characterization of process-related (synthesis and formulation) impurities and degradation products to meet critical requlatory requirements.It''s objective is to provide guidance on isolating and characterizing impurities of pharmaceuticals such as drug candidates, drug substances, and drug products. The book outlines impurity identification processes and will be a key resource document for impurity analysis, isolation/synthesis, and characterization.- Provides valuable information on isolation and characterization of impurities. - Gives a regulatory perspective on the subject. - Describes various considerations involved in meeting regulatory requirements. - Discusses various sources of impurities and degredation products.

It is generally recognized that the commercial success of biotechnology products is highly dependent on the successful development and application of high-powered separation and purification methods. In this practical and authoritative handbook, the separation of proteins, nucleic acids, and oligonucleotides from biological matrices is covered from analytical to process scales. Also included in a chapter on the separation of monoclonal antibodies, which have found numerous uses as therapeutic and diagnostic agents. Analytical techniques include an interesting montage of chromatographic methods, capillary electrophoresis, isoelectric focusing, and mass spectrometry. Among separation and purification methods, liquid-liquid distribution, displacement chromatography, expanded bed adsorption, membrane chromatography, and simulated moving bed chromatography are covered at length. Regulatory and economic considerations are addressed, as are plant and process equipment and engineering process control. A chapter on future developments highlights the application of DNA chip arrays as well as evolving methodologies for a large number of drugs that are under development for treatment of cancer, AIDS, rheumatoid arthritis, and Alzheimer''s disease. Handbook of Bioseparations serves as an essential reference and guidebook for separation scientists working in the pharmaceutical and biotechnology industries, academia, and government laboratories.Key Features* Covers bioseparations of proteins, nucleic acids, and monoclonal antibodies* Encompasses both analytical and process-scale methods* Elucidates the importance of engineering process control* Details selection of plant and process equipment* Addresses economic considerations* Discusses future developments

Isoelectric focusing (IEF) is a high-resolution, stand-alone technique that can be used as an analytical method or tool for protein purification. The only current book on the market, the Handbook of Isoelectric Focusing and Proteomics is the ideal ''one-stop'' source for germane information in this discipline. This highly practical book also contains chapters on alternative methods that may pave the way in the search for efficient techniques for fractionating and purifying proteins. Complete with the history of IEF focusing to authors'' insights and practical tips, this book is a must for anyone working in proteomics.* Is the only current book available on the subject * Includes author insights and practical tips* Is an ideal single source for students and researchers working in proteomics

High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective.HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge.- Covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory- Provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities)- Discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase

Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These characteristics are very attractive in research and development, even more so in pharmaceutical quality control (QC) and stability monitoring (SM) studies. This book will provide busy pharmaceutical scientists a complete yet concise reference guide for utilizing the versatility of CE in new drug development and quality control.- Provides current status and future developments in CE analysis of pharmaceuticals.- Explains how to develop and validate methods.- Includes major pharmaceutical applications including assays and impurity testing.

This work provides those involved in water purification research and administration with a comprehensive resource of methods for analyzing water to assure its safety from contaminants, both natural and human caused. The book first provides an overview of major water-related issues in developing and developed countries, followed by a review of issues of sampling for water analysis, regulatory considerations and forensics in water quality and purity investigations. The subsequent chapters cover microbial as well chemical contaminations from inorganic compounds, radionuclides, volatile and semi-volatile compounds, disinfectants, herbicides, and pharmaceuticals, including endocrine disruptors, as well as potential terrorist-related contamination. The last chapter describes the Grainger prize-winning filter that can remove arsenic from water sources and sufficiently protect the health of a large number of people.- Covers the scope of water contamination problems on a worldwide scale- Provides a rich source of methods for analyzing water to assure its safety from natural and deliberate contaminants- Describes the filter that won the $1 million Grainger prize and thereby highlighting an important approach to remediation

High pressure liquid chromatography-frequently called high performance liquid chromatography (HPLC or, LC) is the premier analytical technique in pharmaceutical analysis and is predominantly used in the pharmaceutical industry. Written by selected experts in their respective fields, the Handbook of Pharmaceutical Analysis by HPLC Volume 6, provides a complete yet concise reference guide for utilizing the versatility of HPLC in drug development and quality control. Highlighting novel approaches in HPLC and the latest developments in hyphenated techniques, the book captures the essence of major pharmaceutical applications (assays, stability testing, impurity testing, dissolution testing, cleaning validation, high-throughput screening). A complete reference guide to HPLC Describes best practices in HPLC and offers 'tricks of the trade' in HPLC operation and method development Reviews key HPLC pharmaceutical applications and highlights currents trends in HPLC ancillary techniques, sample preparations, and data handling

Isoelectric focusing (IEF) is a high-resolution, stand-alone technique that can be used as an analytical method or tool for protein purification. The only current book on the market, the Handbook of Isoelectric Focusing and Proteomics is the ideal 'one-stop' source for germane information in this discipline. This highly practical book also contains chapters on alternative methods that may pave the way in the search for efficient techniques for fractionating and purifying proteins. Complete with the history of IEF focusing to authors' insights and practical tips, this book is a must for anyone working in proteomics.* Is the only current book available on the subject * Includes author insights and practical tips* Is an ideal single source for students and researchers working in proteomics

High pressure, or high performance, liquid chromatography (HPLC) is the method of choice for checking purity of new drug candidates, monitoring changes during scale up or revision of synthetic procedures, evaluating new formulations, and running control/assurance of the final drug product. HPLC Method Development for Pharmaceuticals provides an extensive overview of modern HPLC method development that addresses these unique concerns. Includes a review and update of the current state of the art and science of HPLC, including theory, modes of HPLC, column chemistry, retention mechanisms, chiral separations, modern instrumentation (including ultrahigh-pressure systems), and sample preparation. Emphasis has been placed on implementation in a pharmaceutical setting and on providing a practical perspective.

HPLC Method Development for Pharmaceuticals is intended to be particularly useful for both novice and experienced HPLC method development chemists in the pharmaceutical industry and for managers who are seeking to update their knowledge.

Covers the requirements for HPLC in a pharmaceutical setting including strategies for software and hardware validation to allow for use in a regulated laboratory Provides an overview of the pharmaceutical development process (clinical phases, chemical and pharmaceutical development activities) Discusses how HPLC is used in each phase of pharmaceutical development and how methods are developed to support activities in each phase

This work provides those involved in water purification research and administration with a comprehensive resource of methods for analyzing water to assure its safety from contaminants, both natural and human caused. The book first provides an overview of major water-related issues in developing and developed countries, followed by a review of issues of sampling for water analysis, regulatory considerations and forensics in water quality and purity investigations. The subsequent chapters cover microbial as well chemical contaminations from inorganic compounds, radionuclides, volatile and semi-volatile compounds, disinfectants, herbicides, and pharmaceuticals, including endocrine disruptors, as well as potential terrorist-related contamination. The last chapter describes the Grainger prize-winning filter that can remove arsenic from water sources and sufficiently protect the health of a large number of people. Covers the scope of water contamination problems on a worldwide scale Provides a rich source of methods for analyzing water to assure its safety from natural and deliberate contaminants Describes the filter that won the $1 million Grainger prize and thereby highlighting an important approach to remediation

Handbook of Modern Pharmaceutical Analysis, Second Edition, synthesizes the complex research and recent changes in the field, while covering the techniques and technology required for today's laboratories. The work integrates strategy, case studies, methodologies, and implications of new regulatory structures, providing complete coverage of quality assurance from the point of discovery to the point of use. Treats pharmaceutical analysis (PA) as an integral partner to the drug development process rather than as a service to it Covers method development, validation, selection, testing, modeling, and simulation studies combined with advanced exploration of assays, impurity testing, biomolecules, and chiral separations Features detailed coverage of QA, ethics, and regulatory guidance (quality by design, good manufacturing practice), as well as high-tech methodologies and technologies from "lab-on-a-chip" to LC-MS, LC-NMR, and LC-NMR-MS

Handbook of Modern Pharmaceutical Analysis, Second Edition, synthesizes the complex research and recent changes in the field, while covering the techniques and technology required for today''s laboratories. The work integrates strategy, case studies, methodologies, and implications of new regulatory structures, providing complete coverage of quality assurance from the point of discovery to the point of use.- Treats pharmaceutical analysis (PA) as an integral partner to the drug development process rather than as a service to it- Covers method development, validation, selection, testing, modeling, and simulation studies combined with advanced exploration of assays, impurity testing, biomolecules, and chiral separations- Features detailed coverage of QA, ethics, and regulatory guidance (quality by design, good manufacturing practice), as well as high-tech methodologies and technologies from "lab-on-a-chip" to LC-MS, LC-NMR, and LC-NMR-MS

Many hydrological, geochemical, and biological processes associated with water reclamation and reuse are poorly understood. In particular, the occurrence and effects of trace organic and inorganic contaminants commonly found in reclaimed water necessitates careful analysis and treatment prior to safe reuse. Water Reclamation and Sustainability is a practical guide to the latest water reclamation, recycling, and reuse theory and practice. From water quality criteria and regulations to advanced techniques and implementation issues, this book offers scientists a toolkit for developing safe and successful reuse strategies. With a focus on specific contaminant removal techniques, this book comprehensively covers the full range of potential inorganic/organic contaminating compounds and highlights proven remediation methods. Socioeconomic implications related to current and future water shortages are also addressed, underscoring the many positive benefits of sustainable water resource management.

Offers pragmatic solutions to global water shortages Provides an overview of the latest analytical techniques for water monitoring Reviews current remediation efforts Covers innovative technologies for green, gray, brown and black water reclamation and reuse

Many hydrological, geochemical, and biological processes associated with water reclamation and reuse are poorly understood. In particular, the occurrence and effects of trace organic and inorganic contaminants commonly found in reclaimed water necessitates careful analysis and treatment prior to safe reuse. Water Reclamation and Sustainability is a practical guide to the latest water reclamation, recycling, and reuse theory and practice. From water quality criteria and regulations to advanced techniques and implementation issues, this book offers scientists a toolkit for developing safe and successful reuse strategies. With a focus on specific contaminant removal techniques, this book comprehensively covers the full range of potential inorganic/organic contaminating compounds and highlights proven remediation methods. Socioeconomic implications related to current and future water shortages are also addressed, underscoring the many positive benefits of sustainable water resource management.- Offers pragmatic solutions to global water shortages- Provides an overview of the latest analytical techniques for water monitoring- Reviews current remediation efforts- Covers innovative technologies for green, gray, brown and black water reclamation and reuse

How will chemists of the future balance competing concerns of environmental stewardship and innovative, cost-effective product development? For chemists to accept the idea that environmental quality and economic prosperity can be intertwined, the concept of the food-energy-water nexus must first be integrated into underlying thought processes. Food, Energy and Water: The Chemistry Connection provides today's scientists with the background information necessary to fully understand the inextricable link between food, energy and water and how this conceptual framework should form the basis for all contemporary research and development in chemistry in particular, and the sciences in general.

Presents a clear, quantitative explanation of the link between food, energy, and water Provides information not currently available in chemistry curricula or synthesized in existing resources Examines the challenges of the food-energy-water nexus from a chemistry perspective within a multi-disciplinary domain Includes the latest research on critical topics such as fracking, water use conflicts, and sustainability in food production cycles

How will chemists of the future balance competing concerns of environmental stewardship and innovative, cost-effective product development? For chemists to accept the idea that environmental quality and economic prosperity can be intertwined, the concept of the food-energy-water nexus must first be integrated into underlying thought processes. Food, Energy and Water: The Chemistry Connection provides today''s scientists with the background information necessary to fully understand the inextricable link between food, energy and water and how this conceptual framework should form the basis for all contemporary research and development in chemistry in particular, and the sciences in general.- Presents a clear, quantitative explanation of the link between food, energy, and water- Provides information not currently available in chemistry curricula or synthesized in existing resources- Examines the challenges of the food-energy-water nexus from a chemistry perspective within a multi-disciplinary domain- Includes the latest research on critical topics such as fracking, water use conflicts, and sustainability in food production cycles

After air, water is the most crucial resource for human survival. To achieve water sustainability, we will have to deal with its scarcity and quality, and find ways to reclaim it from various sources. Chemistry and Water: The Science Behind Sustaining the World's Most Crucial Resource applies contemporary and sophisticated separation science and chromatographic methods to address the pressing worldwide concerns of potable water for drinking and safe water for irrigation to raise food for communities around the world.

Edited and authored by world-leading analytical chemists, the book presents the latest research and solutions on topics including water quality and pollution, water treatment technologies and practices, watershed management, water quality and food production, challenges to achieving sustainable water supplies, water reclamation techniques, and wastewater reuse.

Explores the role water plays to assure our survival and maintain life Provides valuable information from world leaders in chemistry and water research Addresses water challenges and solutions globally to ensure sustainability

After air, water is the most crucial resource for human survival. To achieve water sustainability, we will have to deal with its scarcity and quality, and find ways to reclaim it from various sources. Chemistry and Water: The Science Behind Sustaining the World''s Most Crucial Resource applies contemporary and sophisticated separation science and chromatographic methods to address the pressing worldwide concerns of potable water for drinking and safe water for irrigation to raise food for communities around the world.Edited and authored by world-leading analytical chemists, the book presents the latest research and solutions on topics including water quality and pollution, water treatment technologies and practices, watershed management, water quality and food production, challenges to achieving sustainable water supplies, water reclamation techniques, and wastewater reuse.- Explores the role water plays to assure our survival and maintain life- Provides valuable information from world leaders in chemistry and water research- Addresses water challenges and solutions globally to ensure sustainability

Ion Chromatography: Instrumentation, Techniques and Applications, Volume 13 in the series Separation Science and Technology, provides a modern overview of all aspects of ion chromatography instrumentation and chemistry techniques, including the historical backdrop of some of the key developments. Most existing books on ion chromatography are focused on single column ion chromatography (rarely used today) or applications, or are outdated. This book covers the broad range of technologies in use and explains the advantages of each, helping both experienced and new practitioners to choose the method they need.

The editors of this book have all played a key role in the success of ion chromatography at Dionex Corporation, the undisputed leader in ion chromatography for more than 40 years, and are in a unique position to describe both the technology and its applications. Ion chromatography is the technique of choice for analyzing ionic or ionizable compounds in various industries, such as pharmaceuticals and food. In addition, it is very useful for monitoring cationic or anionic impurities in drinking water.

Covers the broad range of technologies currently used in ion chromatography, with an explanation of not only how the technology works, but also which commonly used approaches represent the best options Provides a solid introduction for new practitioners to improve background knowledge on troubleshooting skills Serves as a comprehensive overview of all approaches in ion chromatography, describing the advantages of various newer technology options over older methodologies still in wide use

Advances in Water Purification Techniques: Meeting the Needs of Developed and Developing Countries provides a variety of approaches to water purification that can help assist readers with their research and applications. Water contamination problems occur frequently worldwide, hence the most updated knowledge on water purification systems can be helpful in employing the right type of filter or other mechanism of decontamination. The problems with arsenic contamination of water in Bangladesh and the lead problem in Flint, Michigan remind us of the need to monitor water pollution rigorously, from both point and non-point sources.

Provides a valuable resource on how to solve water contamination problems or develop new approaches to water purification Presents advanced methods for monitoring water contamination Describes various approaches to water purification Encourages new developments in water purification techniques Includes methods for assessing and monitoring environmental contaminants Covers recent advancement in molecular techniques

Advances in Water Purification Techniques: Meeting the Needs of Developed and Developing Countries provides a variety of approaches to water purification that can help assist readers with their research and applications. Water contamination problems occur frequently worldwide, hence the most updated knowledge on water purification systems can be helpful in employing the right type of filter or other mechanism of decontamination. The problems with arsenic contamination of water in Bangladesh and the lead problem in Flint, Michigan remind us of the need to monitor water pollution rigorously, from both point and non-point sources.- Provides a valuable resource on how to solve water contamination problems or develop new approaches to water purification- Presents advanced methods for monitoring water contamination- Describes various approaches to water purification- Encourages new developments in water purification techniques- Includes methods for assessing and monitoring environmental contaminants- Covers recent advancement in molecular techniques

Evaluating Water Quality to Prevent Future Disasters, volume 11 in the Separation Science and Technology series, covers various separation methods that can be used to avoid water catastrophes arising from climate change, arsenic, lead, algal bloom, fracking, microplastics, flooding, glyphosphates, triazines, GenX, and oil contamination. This book provides a valuable resource that will help the reader solve their potential water contamination problems and help them develop their own new approaches to monitor water contamination.

Highlights reasons for potential water catastrophes Provides separation methods for monitoring water contamination Encourages development of new methods for monitoring water contamination

Handbook of Water Purity and Quality, Second Edition provides those involved in water purification research and administration with a comprehensive resource of methods for analyzing water to assure its safety from contaminants, both natural and human caused. The book includes an overview of the subject and discusses major water-related issues in developing and developed countries. Issues covered include sampling for water analysis, regulatory considerations, and forensics in water quality and purity investigations. Microbial as well as chemical contaminations from inorganic compounds, radionuclides, disinfectants, pesticides, and pharmaceuticals, including endocrine disruptors, are discussed at length.

In addition, the luxury of municipal water purified for human consumption is unavailable for a very large number of people. To help solve this problem, some economical water purification techniques, including a million-dollar Grainger prizewinner that can save millions of lives have been included. This fully updated second edition includes four new chapters on topics such as the GenX Water Contamination Problem, the impact of climate change on water, and green chemistry solutions to water pollution.

Covers the scope of water contamination problems on a worldwide scale with an overview of major water-related issues in developing and developed countries, including monitoring techniques for potential terrorist-related activities Provides a rich source of methods for analyzing water to ensure its safety from natural and deliberate contaminants Includes a review of water quality forensics with the objective of tracking new potential water contaminants

Handbook of Water Purity and Quality, Second Edition provides those involved in water purification research and administration with a comprehensive resource of methods for analyzing water to assure its safety from contaminants, both natural and human caused. The book includes an overview of the subject and discusses major water-related issues in developing and developed countries. Issues covered include sampling for water analysis, regulatory considerations, and forensics in water quality and purity investigations. Microbial as well as chemical contaminations from inorganic compounds, radionuclides, disinfectants, pesticides, and pharmaceuticals, including endocrine disruptors, are discussed at length.In addition, the luxury of municipal water purified for human consumption is unavailable for a very large number of people. To help solve this problem, some economical water purification techniques, including a million-dollar Grainger prizewinner that can save millions of lives have been included. This fully updated second edition includes four new chapters on topics such as the GenX Water Contamination Problem, the impact of climate change on water, and green chemistry solutions to water pollution.- Covers the scope of water contamination problems on a worldwide scale with an overview of major water-related issues in developing and developed countries, including monitoring techniques for potential terrorist-related activities- Provides a rich source of methods for analyzing water to ensure its safety from natural and deliberate contaminants- Includes a review of water quality forensics with the objective of tracking new potential water contaminants

Separations of Water Pollutants with Nanotechnology, the latest volume in the Separation Science and Technology series, offers new solutions for remediating water pollution utilizing nanomaterials with separation methods. Current water purification methods are unsuitable, inconvenient or expensive, so there is a need for new and better processes and techniques. Nanomaterials can purify water by removing pollutants such as heavy metals, pathogens, organic compounds, inorganic compounds, pharmaceuticals, and chemicals of emerging concern. These can effectively replace membrane-based methods if the right expertise is developed-this book helps separation scientists do just that. Existing water treatment problems can be solved by applying a nanotechnology-based processes: antimicrobial nanotechnology, zero-valent iron nanoparticles, nanoadsorbents, nano-enhanced membranes, nanometal oxides, and nano photocatalysts. The current literature places emphasis on materials chemistry rather than the separation methods used for water purification. This new volume presents a collection of chapters that deal with remediation based on separation chemistry. Written by leaders in their respective fields from around the world and edited by Satinder Ahuja, a leading expert on water quality improvement Covers the environmental impact of anthropogenic nanoparticles and plant derived bionanomaterials, which are not contained in other books related to nanomaterials for water purification Illustrates key information visually wherever possible throughout the book, e.g. process diagrams in the nanomaterial synthesis and nanomembrane fabrication chapters, electron microscope images, and more