Sergey Shityakov – författare

Membrane Technologies in Cancer and Environmental Health explores the critical intersection of health and environmental quality amid rising challenges like cancer prevalence and water contamination. The book addresses how environmental pollutants contribute to cancer development and emphasizes the need for innovative approaches in both cancer treatment and environmental health, focusing on the transformative potential of membrane technologies. Chapters synthesize research on membrane technologies, showcasing their applications in targeted cancer therapies and water purification. Detailed case studies illustrate the effectiveness of techniques such as reverse osmosis and nanofiltration in removing contaminants, thereby enhancing public health and providing clean water access.Academics benefit from gaining a cohesive understanding of how advancements in membrane technology can address both cancer treatment and environmental health challenges. This interdisciplinary approach fosters collaboration and informs future research directions, ultimately promoting awareness of clean water's vital role in cancer prevention.Bridges the gap between cancer treatment and environmental health, fostering collaboration among researchers, healthcare professionals, and policymakers to address the interconnected challenges of cancer and water qualityShowcases cutting-edge applications of membrane technologies, providing detailed case studies that demonstrate their effectiveness in enhancing targeted drug delivery systems and purifying contaminated water sourcesSynthesizes existing research on membrane technologies, offering a cohesive understanding of their dual role in improving healthcare outcomes and ensuring access to clean water

Doctoral Thesis / Dissertation from the year 2011 in the subject Biology - Micro- and Molecular Biology, grade: 1 (magna cum laude), University of Wurzburg (Theodor-Boveri-Insitut fur Biowissenschaften), course: computer science, virology, biophysics, language: English, abstract: HIV-1 integrase has nuclear localization signals (NLS) which play a crucial role in nuclear import of viral preintegration complex (PIC). However, the detailed mechanisms of PIC formation and its nuclear transport are not known. I investigated the interaction of this viral protein HIV-1 integrase with proteins of the nuclear pore complex such as transportin-SR2 (Shityakov et al., 2010). I showed that the transportin-SR2 in nuclear import is required due to its interaction with the HIV-1 integrase. I analyzed key domain interaction, and hydrogen bond formation in transportin-SR2. In this thesis, I compared the transduction frequencies of PPT modified FV vectors with lentiviral vectors in nondividing and dividing alveolar basal epithelial cells from human adenocarcinoma (A549) by using molecular cloning, transfection and transduction techniques and several other methods. In contrast to lentiviral vectors, FV vectors were not able to efficiently transduce nondividing cell (Shityakov and Rethwilm, unpublished data). Despite the findings, which support the use of FV vectors as a safe and efficient alternative to lentiviral vectors, major limitation in terms of foamy-based retroviral vector gene transfer in quiescent cells still remains. In computational drug design I used molecular modelling methods such as lead expansion algorithm (Tripos ) to create a virtual library of compounds with different binding affinities to protease binding site. Further computational analyses revealed one unique compound with different protease binding ability from the initial hit and its role for possible new class of protease inhibitors is discussed (Shityakov and Dandekar, 2009). The phenomenon of an intercalated single-wall carbon nanotube in the centre of lipid membrane was extensively studied and analyzed. The root mean square deviation and root mean square fluctuation functions were calculated in order to measure stability of lipid membranes. The results indicated that an intercalated carbon nanotube restrains the conformational freedom of adjacent lipids and hence has an impact on the membrane stabilization dynamics (Shityakov and Dandekar, 2011). The results derived from this thesis will help to develop stable nanobiocomposites for construction of novel biomaterials and delivery of various biomolecules for medicine and biology.