Seth Michelson - Böcker

The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries.The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification.Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.

From an award-winning poet comes a humanizing story of immigration shown through the lens of undocumented, unaccompanied children and the poems they write.“Heartfelt . . . a surprisingly uplifting call to reform an unjust system.” –Publishers WeeklyIn heart-wrenching prose, Seth Michelson faces the U.S. immigration crisis head on—by learning and sharing the stories of migrating people fleeing violence and poverty, and by leading workshops for minors held inside a maximum-security detention center. Highlighting the experiences of people desperate for safety, Michelson tirelessly fights for justice and their freedom. Guided through the powerful medium of poetry, the children share their pasts, struggles, hopes, and dreams. Among them, Carlitos, a 13-year-old boy who escaped a gang to try to make a safe and honest life on his own after his mother’s death, and Karla, a teenager whose family begged her to flee for safety after she was shot. Remarkably, they and other children from similar circumstances express themselves with honesty, passion, and optimism for a better future. Michelson also introduces us to migrating people at the border, including a woman who was chased from her home amid violence, and a dedicated father who was arrested and beaten while searching for work to make a more secure life for his wife and daughter. Whether relating experiences in a Mexican refugee camp or a U.S. immigration detention center, Michelson’s prose is brisk and gripping, offering hard-earned insights into ways we might create a better immigration system that treats all people with dignity.