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In this issue of Cardiology Clinics, guest editors Drs. Silvi Shah and Janani Rangaswami bring their considerable expertise to the topic of Cardio-Kidney-Metabolic Disorder. Top experts discuss key topics such as definition, staging, risk assessment, and therapeutic considerations; sex difference in CVD with kidney disease; obesity and CKM health: ethnicity-based risk and clinical considerations; SGLT2i across the spectrum of CKM health; and more.