New Horizons for Failing Heart Syndrome brings together the latest knowledge on heart failure syndrome and the status of research on heart failure in Japan, compiling the results of the Japanese Circulation Society''s second research series. Contents include the molecular mechanism of heart failure, mechanics of contraction of the failing heart, energetics of the failing heart, exercise physiology, and new aspects of management of heart failure. The Japanese Circulation Society''s 3-year project for research on heart failure was conducted in two series, the first from 1988 to 1991 and the second from 1992 to the spring of 1995. The present volume embodies the most up-to-date overview of current research being carried out in Japan today, and will be of special interest to cardiologists, researchers, and other practitioners in the field.

New Horizons for Failing Heart Syndrome brings together the latest knowledge on heart failure syndrome and the status of research on heart failure in Japan, compiling the results of the Japanese Circulation Society's second research series. Contents include the molecular mechanism of heart failure, mechanics of contraction of the failing heart, energetics of the failing heart, exercise physiology, and new aspects of management of heart failure. The Japanese Circulation Society's 3-year project for research on heart failure was conducted in two series, the first from 1988 to 1991 and the second from 1992 to the spring of 1995. The present volume embodies the most up-to-date overview of current research being carried out in Japan today, and will be of special interest to cardiologists, researchers, and other practitioners in the field.

Heart failure is a syndrome caused by a heart dysfunction that leads to insuf­ ficient blood in the peripheral tissues for their metabolic demands. This syn­ drome still remains an obscure clinical entity and even its definition is disputed. It has become increasingly apparent that heart failure may relate not only to cardiac dysfunction but also to other physiological alterations involved in the maintenance of circulatory homeostasis. In 1988, the Japanese Circulation Society organized a three-year project for research on heart failure. The research group consisted of ten investigators, all relatively young but well recognized internationally for their research accomplishments. This book represents a compilation of the achievements by this group during the past three years which have led to new insights into the pathophysiologic mechanisms of heart failure, and diagnosis, evaluation and treatment of this syndrome. Contents include research into the cellular biology of congestive heart failure, and a framework of pressure-volume relationships enabling assessment of ventricular contraction energetics or coupling of ventricular properties and arterial load. This conceptual framework is of vital significance, particularly when we consider the failing heart as an energy-depleted state. An understanding of the neuroendocrine responses to explain the pathophy­ siology of congestive heart failure is perhaps the most important advance, and has led to new developments in therapy. This book also includes an analysis of mechanical factors, including both regional, and global ventricular functions, and this is related to the under­ standing of the pathophysiology of congestive heart failure.

Heart failure is a syndrome caused by a heart dysfunction that leads to insuf­ ficient blood in the peripheral tissues for their metabolic demands. This syn­ drome still remains an obscure clinical entity and even its definition is disputed. It has become increasingly apparent that heart failure may relate not only to cardiac dysfunction but also to other physiological alterations involved in the maintenance of circulatory homeostasis. In 1988, the Japanese Circulation Society organized a three-year project for research on heart failure. The research group consisted of ten investigators, all relatively young but well recognized internationally for their research accomplishments. This book represents a compilation of the achievements by this group during the past three years which have led to new insights into the pathophysiologic mechanisms of heart failure, and diagnosis, evaluation and treatment of this syndrome. Contents include research into the cellular biology of congestive heart failure, and a framework of pressure-volume relationships enabling assessment of ventricular contraction energetics or coupling of ventricular properties and arterial load. This conceptual framework is of vital significance, particularly when we consider the failing heart as an energy-depleted state. An understanding of the neuroendocrine responses to explain the pathophy­ siology of congestive heart failure is perhaps the most important advance, and has led to new developments in therapy. This book also includes an analysis of mechanical factors, including both regional, and global ventricular functions, and this is related to the under­ standing of the pathophysiology of congestive heart failure.

Heart failure is a syndrome caused by a heart dysfunction that leads to insuf­ ficient blood in the peripheral tissues for their metabolic demands. This syn­ drome still remains an obscure clinical entity and even its definition is disputed. It has become increasingly apparent that heart failure may relate not only to cardiac dysfunction but also to other physiological alterations involved in the maintenance of circulatory homeostasis. In 1988, the Japanese Circulation Society organized a three-year project for research on heart failure. The research group consisted of ten investigators, all relatively young but well recognized internationally for their research accomplishments. This book represents a compilation of the achievements by this group during the past three years which have led to new insights into the pathophysiologic mechanisms of heart failure, and diagnosis, evaluation and treatment of this syndrome. Contents include research into the cellular biology of congestive heart failure, and a framework of pressure-volume relationships enabling assessment of ventricular contraction energetics or coupling of ventricular properties and arterial load. This conceptual framework is of vital significance, particularly when we consider the failing heart as an energy-depleted state. An understanding of the neuroendocrine responses to explain the pathophy­ siology of congestive heart failure is perhaps the most important advance, and has led to new developments in therapy. This book also includes an analysis of mechanical factors, including both regional, and global ventricular functions, and this is related to the under­ standing of the pathophysiology of congestive heart failure.

New Horizons for Failing Heart Syndrome brings together the latest knowledge on heart failure syndrome and the status of research on heart failure in Japan, compiling the results of the Japanese Circulation Society''s second research series. Contents include the molecular mechanism of heart failure, mechanics of contraction of the failing heart, energetics of the failing heart, exercise physiology, and new aspects of management of heart failure. The Japanese Circulation Society''s 3-year project for research on heart failure was conducted in two series, the first from 1988 to 1991 and the second from 1992 to the spring of 1995. The present volume embodies the most up-to-date overview of current research being carried out in Japan today, and will be of special interest to cardiologists, researchers, and other practitioners in the field.

New Horizons for Failing Heart Syndrome brings together the latest knowledge on heart failure syndrome and the status of research on heart failure in Japan, compiling the results of the Japanese Circulation Society's second research series. Contents include the molecular mechanism of heart failure, mechanics of contraction of the failing heart, energetics of the failing heart, exercise physiology, and new aspects of management of heart failure. The Japanese Circulation Society's 3-year project for research on heart failure was conducted in two series, the first from 1988 to 1991 and the second from 1992 to the spring of 1995. The present volume embodies the most up-to-date overview of current research being carried out in Japan today, and will be of special interest to cardiologists, researchers, and other practitioners in the field.

Heart failure is a syndrome caused by a heart dysfunction that leads to insuf­ ficient blood in the peripheral tissues for their metabolic demands. This syn­ drome still remains an obscure clinical entity and even its definition is disputed. It has become increasingly apparent that heart failure may relate not only to cardiac dysfunction but also to other physiological alterations involved in the maintenance of circulatory homeostasis. In 1988, the Japanese Circulation Society organized a three-year project for research on heart failure. The research group consisted of ten investigators, all relatively young but well recognized internationally for their research accomplishments. This book represents a compilation of the achievements by this group during the past three years which have led to new insights into the pathophysiologic mechanisms of heart failure, and diagnosis, evaluation and treatment of this syndrome. Contents include research into the cellular biology of congestive heart failure, and a framework of pressure-volume relationships enabling assessment of ventricular contraction energetics or coupling of ventricular properties and arterial load. This conceptual framework is of vital significance, particularly when we consider the failing heart as an energy-depleted state. An understanding of the neuroendocrine responses to explain the pathophy­ siology of congestive heart failure is perhaps the most important advance, and has led to new developments in therapy. This book also includes an analysis of mechanical factors, including both regional, and global ventricular functions, and this is related to the under­ standing of the pathophysiology of congestive heart failure.

Heart failure is a syndrome caused by a heart dysfunction that leads to insuf­ ficient blood in the peripheral tissues for their metabolic demands. This syn­ drome still remains an obscure clinical entity and even its definition is disputed. It has become increasingly apparent that heart failure may relate not only to cardiac dysfunction but also to other physiological alterations involved in the maintenance of circulatory homeostasis. In 1988, the Japanese Circulation Society organized a three-year project for research on heart failure. The research group consisted of ten investigators, all relatively young but well recognized internationally for their research accomplishments. This book represents a compilation of the achievements by this group during the past three years which have led to new insights into the pathophysiologic mechanisms of heart failure, and diagnosis, evaluation and treatment of this syndrome. Contents include research into the cellular biology of congestive heart failure, and a framework of pressure-volume relationships enabling assessment of ventricular contraction energetics or coupling of ventricular properties and arterial load. This conceptual framework is of vital significance, particularly when we consider the failing heart as an energy-depleted state. An understanding of the neuroendocrine responses to explain the pathophy­ siology of congestive heart failure is perhaps the most important advance, and has led to new developments in therapy. This book also includes an analysis of mechanical factors, including both regional, and global ventricular functions, and this is related to the under­ standing of the pathophysiology of congestive heart failure.

Heart failure is a syndrome caused by a heart dysfunction that leads to insuf­ ficient blood in the peripheral tissues for their metabolic demands. This syn­ drome still remains an obscure clinical entity and even its definition is disputed. It has become increasingly apparent that heart failure may relate not only to cardiac dysfunction but also to other physiological alterations involved in the maintenance of circulatory homeostasis. In 1988, the Japanese Circulation Society organized a three-year project for research on heart failure. The research group consisted of ten investigators, all relatively young but well recognized internationally for their research accomplishments. This book represents a compilation of the achievements by this group during the past three years which have led to new insights into the pathophysiologic mechanisms of heart failure, and diagnosis, evaluation and treatment of this syndrome. Contents include research into the cellular biology of congestive heart failure, and a framework of pressure-volume relationships enabling assessment of ventricular contraction energetics or coupling of ventricular properties and arterial load. This conceptual framework is of vital significance, particularly when we consider the failing heart as an energy-depleted state. An understanding of the neuroendocrine responses to explain the pathophy­ siology of congestive heart failure is perhaps the most important advance, and has led to new developments in therapy. This book also includes an analysis of mechanical factors, including both regional, and global ventricular functions, and this is related to the under­ standing of the pathophysiology of congestive heart failure.