Shyamasree Ghosh - Böcker

Sialic Acids and Sialoglycoconjugates in the Biology of Life, Health and Disease enables the reader to understand the role of sialylation as a post translational modification. The book provides insights on the latest knowledge in the field of sialoglycobiology. Sialic acids as terminal residues of oligosaccharide chains play crucial roles in several cellular recognition events. Synthesized post translationally, they play an important role in recognition, signaling, immunological response and cell-cell interaction. Improper sialylations have been associated with several diseases including cancer. In the post genomics and proteomics era, sialoglybiology has become more and more important in deciphering health and disease conditions.

Discusses the sialic acids and their role in different diseases (other than cancer) Provides an understanding of sialylations as post translational modifications (PTM) Demonstrates the impact sialylation has on infectious diseases, the autoimmune system and health Gives insights on the importance of sialic acid biology through animal models

Glycobiology of the Immune System and Disease explores the integration of state-of-the-art glycobiology and immunology to raise awareness of the multifaceted roles of glycans and lectins in the immune system. Glycobiology is a rapidly growing field in biology, with relevance to biomedicine, biotechnology and basic research. Considering the central role that glycans play in immune interactions, glycoproteins and carbohydrates are becoming the targets of next-generation therapeutics, vaccines and diagnostics. Programmed remodeling of host glycans can modulate infection, autoimmunity, and cancer, while microbial glycoconjugates can serve as canonical innate receptor agonists that induce B cell and T cell activation. This important reference investigates microbial and mammalian glycans and their protein-binding partners (lectins) and shows the role they play in all innate and adaptive immune responses. With its comprehensive overview of the field, it is an important resource for academicians, graduate and post graduate students as well as professors and faculty in the field of research in glycobiology and immunology.

Provides the first book on the glycobiology of the immune systemGives insights on the glycobiology of the epidemic and pandemic causing virus H1N1/H5N1, Coronavirus and COVID-19Highlights the importance of glycobiology and its probable role in generating therapy for viral infectionsProvides up-to-date and accessible information for beginners in glycoimmunology and for readers with an interest in infectious diseases and host response

The book explores the intricate connections between the nervous and immune systems in the context of neurodegenerative disorders, offering a comprehensive overview of the bidirectional communication between these systems and their implications for disease progression and therapeutic interventions. The book aims to understand the recent developments in the field of neuroimmune communication.Key Features:In-depth analysis of immunological biomarkers and therapeutic targets for neurodegenerative disorders.Exploration of the role of glial cells in neuroimmune interactions and their dual nature in disease pathology.Examination of short- and long-range interactions between the central nervous system (CNS) and immune system, including hormonal axis and cytokine milieu.Discussion on the impact of microbiota on neural networks and immune responses, highlighting the gut-brain axis and potential therapeutic avenues.Utilization of Drosophila model systems to study neurodegeneration, providing insights into disease mechanisms and potential treatment strategies.Coverage of various neurodegenerative disorders, including Alzheimer’s, Parkinson’s, polyglutamine-related diseases, and tauopathy, with a focus on understanding disease progression and identifying therapeutic targets.The book stands out for its interdisciplinary approach, bridging the fields of neuroscience, immunology, and microbiology to provide a holistic understanding of neurodegenerative diseases. It offers valuable insights into the complex interplay between the nervous and immune systems, shedding light on novel therapeutic avenues for treating these debilitating conditions. Suitable for researchers, clinicians, and students in the fields of neurology, immunology, and microbiology, this book serves as an essential resource for understanding the pathogenesis and treatment of neurodegenerative disorders.

The tumor microenvironment (TME) plays a significant role in influencing tumor aggressiveness and therapeutic outcomes, presenting both challenges and opportunities in oncology. The Dynamics of Tumor Microenvironment and Therapeutic Targets provides a detailed overview of the complex nature of the TME, highlighting its dynamic cellular and molecular components. Each chapter systematically examines a specific element of the TME, outlining its role in tumor initiation, progression, dormancy, and suppression. The book discusses the use of molecular inhibitors that disrupt tumor-promoting interactions within the TME. Additionally, it covers immune therapies designed to reprogram immune cells in the TME to enhance the effectiveness and durability of cancer treatments. This volume also addresses recent advancements in therapeutic strategies targeting the TME, including the incorporation of contemporary computational methods. Notably, the application of artificial intelligence (AI) and machine learning (ML) to TME analysis is explored, showcasing their utility in biomarker discovery and the development of precision oncology tools.Key FeaturesComprehensive coverage of the cellular and noncellular components of the TME, with an emphasis on their phenotypic and functional heterogeneity.Detailed discussion of both targetable and non-targetable elements of the TME and their relevance in therapeutic development.A dedicated chapter on AI-/ML-based methodologies for TME profiling, reflecting the emerging role of computational biology in oncology research.Critical descriptions of clinical trials targeting various aspects of the TME, alongside a synthesis of relevant translational and preclinical studies.This volume serves as a valuable resource for graduate students, early career researchers, and established investigators in cancer biology, tumor immunology, and translational oncology. It provides foundational knowledge as well as insights into emerging therapeutic paradigms centered on the TME.

Earthworms: Biology and Life is a scientifically rich and comprehensive exploration of earthworm biology, diversity, and ecological significance, with a particular emphasis on the Indian subcontinent and its global context. The book begins with an overview of the global distribution and biogeography of Clitellata and Megadrili, then transitions into a detailed account of India’s terrestrial and aquatic earthworm fauna. By blending regional richness with global insights, the book offers readers a nuanced understanding of species diversity, ecological roles, and habitat specialization across forest floors, agricultural lands, and freshwater ecosystems.What sets this book apart is its integrated approach to the anatomy, physiology, and behavior of earthworms, combined with modern perspectives on their ecological importance, such as the role of gut microbiomes, vermicomposting technologies, and bioindicator functions. It synthesizes classical taxonomy with recent molecular studies, ensuring both foundational and contemporary scientific coverage. The inclusion of applied aspects like sustainable agriculture, waste management, and conservation underscores its relevance to both research and real-world applications.Key FeaturesComprehensive coverage of earthworm taxonomy, including global distribution and Indian species diversityIn-depth examination of life cycle, reproductive strategies, and developmental stagesAnalysis of the anatomy, behavior, and physiology related to feeding, burrowing, and reproductionDetailed exploration of the gut microbiome and its role in nutrient cycling and soil healthEmphasis on ecological roles in terrestrial and aquatic environments, including invasive species impactsThorough discussion on the use of earthworms as bioindicators of soil and environmental qualityPractical insights into vermicomposting, organic waste management, and sustainable agricultureEvolutionary perspective linking classical taxonomy with molecular approachesFocus on conservation challenges such as habitat loss, pollution, and pesticide exposureInterdisciplinary approach combining zoology, ecology, environmental science, and applied biologyThis book is an essential resource for zoologists, ecologists, soil scientists, conservationists, environmental biologists, and students in related fields. With its integration of taxonomy, physiology, ecology, and applied environmental science, Earthworms: Biology and Life serves both academic and practical needs, offering a holistic and authoritative perspective on one of nature’s most important invertebrates. Whether for research, education, or sustainable development, this book bridges scientific insight with environmental stewardship.

The immune system is highly complex system with large number of macromolecules, signaling pathways, protein-protein interactions, and gene expressions. Studies from genomics, transcriptomics, metabolomics are generating huge high throughput data that needs to be analyzed for understanding the Immune system in Health and Disease. Computational approaches arehelping in understanding the study of complex biology of immunology and thereby enabling design of therapeutic strategies in diseases like infectious diseases, immunodeficiency, allergic, hypersensitive, autoimmune disorders and diseases like Cancer, HIV etc. Computational Immunology: Basics highlights the basics of the immune system and function in health and disease.This book offers comprehensive coverage of the most essential topics, including Overview of Immunology and computational Immunology Immune organs and cells, antigen, antibody, B, cell, T cell Antigen Processing and presentation Diseases due to abnormalities of the immune system Cancer BiologyShyamasree Ghosh (MSc, PhD, PGDHE, PGDBI), is currently working in the School of Biological Sciences, National Institute of Science Education and Research (NISER), Bhubaneswar, DAE, Govt of India, graduated from the prestigious Presidency College Kolkata in 1998. She was awarded the prestigious National Scholarship from the Government of India. She has worked and published extensively in glycobiology, sialic acids, immunology, stem cells and nanotechnology. She has authored several publications that include books and encyclopedia chapters in reputed journals and books.

Computational Immunology: Applications focuses on different mathematical models, statistical tools, techniques, and computational modelling that helps in understanding complex phenomena of the immune system and its biological functions. The book also focuses on the latest developments in computational biology in designing of drugs, targets, biomarkers for early detection and prognosis of a disease. It highlights the applications of computational methods in deciphering the complex processes of the immune system and its role in health and disease. This book discusses the most essential topics, including Next generation sequencing (NGS) and computational immunologyComputational modelling and biology of diseasesDrug designing Computation and identification of biomarkersApplication in organ transplantationApplication in disease detection and therapyComputational methods and applications in understanding of the invertebrate immune systemS Ghosh is MSc, PhD, PGDHE, PGDBI, is PhD from IICB, CSIR, Kolkata, awarded the prestigious National Scholarship from the Government of India. She has worked and published extensively in glycobiology, sialic acids, immunology, stem cells and nanotechnology. She has authored several publications that include books and encyclopedia chapters in reputed journals and books.

This monograph summarizes the current knowledge on potential health hazards induced by nanomaterials from different sources and sort such as food, drugs and silver nanoparticles. Methods to assess toxicity as well as known effects on the genome, neuronal and respiratory system are discussed. Besides the impact on human and animal life the books also addresses aquatic toxicity.

The fast development in the field of nanotechnology has led to a high variety of nanoparticles. Nanoparticles find importance in every sphere of human lives and more so in the recent years have tremendous applications in the sector of biomedical clinical medicine as diagnostic, prognostic and imaging tools. Their risk to human and animal life as well as to the environment is still unclear. Therefore, the study of the impact of nanoparticles on human and animal life is important. Volume I highlights the impact of nanoparticles on the human immune system. While discussing the basic biology of the immune system, this book highlights the downstream effect of nanoparticles on the human immune system. Research studies on the development of better and more effective nanoparticles with more precise and accurate effects and with toxic minimal side effects are discussed in the book. Both volumes are also included in a set ISBN 978-3-11-065666-4.

Applications of nanoparticles to the human life and tools in diagnosis and therapy in field of clinical medicine holds importance and has been an prime focus of biomedical and clinical research for quite sometime, though their application in veterinary medicine is a relatively new focus area of research. Prior to human applications, studies are initially conducted on animals models. Thus toxicity based studies and study of impact of nanoparticles on animal immune system finds importance. In the second volume of the book we discuss the immune system in animals across invertebrates and vertebrate phylas and discuss the impact of nanoparticles in animals life, health, survival and immune system. The book highlights the toxic effects of nanoparticles as environmental pollutants and their adverse impact on animal life forms. Both volumes are also included in a set ISBN 978-3-11-065666-4.

This book offers a comprehensive study of C-reactive protein (CRP) belonging to the pentraxin family, including a brief history of CRP, its structure, synthesis and evolution.  Focusing on the emerging role of CRP and its clinical application in the field of disease biology, it details the pathophysiological role of CRP in a host of diseases such as cardiovascular disease, diabetes, cancers, rheumatoid arthritis and infectious diseases and others. It also discusses the role of innate immunity and acute phase response (APR) and their key mediators in the host body in response to tissue injury, infection, trauma or surgery, immunological disorders or neoplastic growth. CRP’s significance in inflammation is highlighted, and its importance as a clinical marker in cardiovascular disease, its functional significance in Leishmania and Plasmodium infections, its association with the development of insulin resistance in type 2 diabetes mellitus, and its role in cancer are discussed in detail.  The book also includes clinical data studies and presents the latest research advances to further readers’ understanding of CRP.

This book explores the latest developments in the field the acute phase protein (APP), C-reactive protein or CRP in different diseases, highlighting the structural and functional aspects of CRP in disease biology.Divided into 5 sections, the book examines important topics such as the role of CRP in neurodegenerative, cardiac and parasitic diseases, as well as in cancer and inflammatory bowel disease, and the expression of CRP in pediatric respiratory diseases. In addition it discusses the clinical role of CRP in diagnostics and therapeutics, sepsis, ICU and ITU patients, and also as a primary marker for inflammation. Given its scope, this book will appeal to scholars in various fields of medicine and biology.

This book explores the latest developments in the field the acute phase protein (APP), C-reactive protein or CRP in different diseases, highlighting the structural and functional aspects of CRP in disease biology.Divided into 5 sections, the book examines important topics such as the role of CRP in neurodegenerative, cardiac and parasitic diseases, as well as in cancer and inflammatory bowel disease, and the expression of CRP in pediatric respiratory diseases. In addition it discusses the clinical role of CRP in diagnostics and therapeutics, sepsis, ICU and ITU patients, and also as a primary marker for inflammation. Given its scope, this book will appeal to scholars in various fields of medicine and biology.

Stem cells hold great promise for cell therapy, tissue engineering, regenerative medicine and pharmaceutical and biotechnological applications. This book highlights the potency of stem cells, their property of self-renewal and their ability to differentiate into different cell lineages. It further describes the different markers to identify stem cells, sources, methods of isolation, culture including 2D, 3D and beyond and their cryopreservation. This is among the first books to discuss glycosylation and sialylation in stem cells. Chapters describe application of stem cells in regenerative medicine and therapy, and highlight their application in cancer therapy and spinal cord injury. The book talks about the important patents on stem cells. The book also highlights the plant stem cells, discussing their pluoripotent nature, role in organ regeneration after injury, specific stem cell niches, that signals to block differentiation studied in plants shoot, root, and vascular meristems, differentiation of plant stem cell, transcriptional regulation and epigenetic modification of plant stem cells.  This book is exciting and cutting edge. It will be of great interest to doctors, students and researchers in the field of regenerative medicine, cancer , biotechnology and  plant sciences.

Stem cells hold great promise for cell therapy, tissue engineering, regenerative medicine and pharmaceutical and biotechnological applications. This book highlights the potency of stem cells, their property of self-renewal and their ability to differentiate into different cell lineages. It further describes the different markers to identify stem cells, sources, methods of isolation, culture including 2D, 3D and beyond and their cryopreservation. This is among the first books to discuss glycosylation and sialylation in stem cells. Chapters describe application of stem cells in regenerative medicine and therapy, and highlight their application in cancer therapy and spinal cord injury. The book talks about the important patents on stem cells. The book also highlights the plant stem cells, discussing their pluoripotent nature, role in organ regeneration after injury, specific stem cell niches, that signals to block differentiation studied in plants shoot, root, and vascular meristems, differentiation of plant stem cell, transcriptional regulation and epigenetic modification of plant stem cells.  This book is exciting and cutting edge. It will be of great interest to doctors, students and researchers in the field of regenerative medicine, cancer , biotechnology and  plant sciences.

This book gives an overview of applications of Machine Learning (ML) in diverse fields of biological sciences, including healthcare, animal sciences, agriculture, and plant sciences.

This book gives an overview of applications of Machine Learning (ML) in diverse fields of biological sciences, including healthcare, animal sciences, agriculture, and plant sciences. Machine learning has major applications in process modelling, computer vision, signal processing, speech recognition, and language understanding and processing and life, and health sciences. It is increasingly used in understanding DNA patterns and in precision medicine. This book is divided into eight major sections, each containing chapters that describe the application of ML in a certain field. The book begins by giving an introduction to ML and the various ML methods. It then covers interesting and timely aspects such as applications in genetics, cell biology, the study of plant-pathogen interactions, and animal behavior. The book discusses computational methods for toxicity prediction of environmental chemicals and drugs, which forms a major domain of research in the field of biology.  It is of relevance to post-graduate students and researchers interested in exploring the interdisciplinary areas of use of machine learning and deep learning in life sciences.

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This book emphasizes the important role of invertebrates in forensic sciences in the detection of crimes, determining the time and place of death, estimating the minimum Post-Mortem Interval (PMI), and determining the cause of death. The initial chapter discusses the forensically essential invertebrates, especially flies under Order Diptera. Further, the book highlights the importance, biology, taxonomy, and biodiversity of flies under Order Diptera with forensic importance. It also discusses the Cuticular HydroCarbons (CHC) and spectrometry-based studies reported from flies and larvae of forensic importance. It further reviews the importance of DNA barcoding in molecular taxonomy-based studies on forensic flies through understanding, identification, and grouping the organisms. Towards the end, this book presents the applications and limitations of forensic entomology in cases of animal cruelty to a veterinary professional.​