Sonali Sundram - Böcker

Nowadays, raw biological data can be easily stored as databases in computers but extracting the required information is the real challenge for researchers. For this reason, bioinformatics tools perform a vital role in extracting and analyzing information from databases. Bioinformatics Tools and Big Data Analytics for Patient describes the applications of bioinformatics, data management, and computational techniques in clinical studies and drug discovery for patient care. The book gives details about the recent developments in the fields of artificial intelligence, cloud computing, and data analytics. It highlights the advances in computational techniques used to perform intelligent medical tasks.Features:Presents recent developments in the fields of artificial intelligence, cloud computing, and data analytics for improved patient care.Describes the applications of bioinformatics, data management, and computational techniques in clinical studies and drug discovery.Summarizes several strategies, analyses, and optimization methods for patient healthcare.Focuses on drug discovery and development by cloud computing and data-driven researchThe targeted audience comprises academics, research scholars, healthcare professionals, hospital managers, pharmaceutical chemists, the biomedical industry, software engineers, and IT professionals.

Nowadays, raw biological data can be easily stored as databases in computers but extracting the required information is the real challenge for researchers. For this reason, bioinformatics tools perform a vital role in extracting and analyzing information from databases. Bioinformatics Tools and Big Data Analytics for Patient describes the applications of bioinformatics, data management, and computational techniques in clinical studies and drug discovery for patient care. The book gives details about the recent developments in the fields of artificial intelligence, cloud computing, and data analytics. It highlights the advances in computational techniques used to perform intelligent medical tasks.Features:Presents recent developments in the fields of artificial intelligence, cloud computing, and data analytics for improved patient care.Describes the applications of bioinformatics, data management, and computational techniques in clinical studies and drug discovery.Summarizes several strategies, analyses, and optimization methods for patient healthcare.Focuses on drug discovery and development by cloud computing and data-driven researchThe targeted audience comprises academics, research scholars, healthcare professionals, hospital managers, pharmaceutical chemists, the biomedical industry, software engineers, and IT professionals.

Blockchain is a type of distributed ledger technology that consists of a growing list of records that are securely linked together using cryptography and numerous applications in every field, including healthcare. Blockchain for Healthcare 4.0: Technology, Challenges, and Applications presents an overview of the recent advances in blockchain technology which have led to new breakthroughs in the healthcare industry, the application of artificial intelligence (AI) with blockchain, challenges, and prospects.Key Features:• Highlights blockchain applications in the biomedical and pharmaceutical industries and remote healthcare. • Discusses applications and advancement in blockchain framework to track diseases and outbreaks.• Elaborates the role of blockchain in managing health records, tracing, and securing medical supplies.• Focuses on efficient and secure medical data sharing through blockchain and secure cloud-based electronic health record (EHR), a system using an attribute-based cryptosystem.• Presents techniques and methods to utilize blockchain technology for clinical studies and facilitates the transition to patient-driven interoperability.The text is primarily written for graduate students and academic researchers in the fields of computer science and engineering, biomedical engineering, electrical engineering, and information technology.

Blockchain is a type of distributed ledger technology that consists of a growing list of records that are securely linked together using cryptography and numerous applications in every field, including healthcare. Blockchain for Healthcare 4.0: Technology, Challenges, and Applications presents an overview of the recent advances in blockchain technology which have led to new breakthroughs in the healthcare industry, the application of artificial intelligence (AI) with blockchain, challenges, and prospects.Key Features:• Highlights blockchain applications in the biomedical and pharmaceutical industries and remote healthcare. • Discusses applications and advancement in blockchain framework to track diseases and outbreaks.• Elaborates the role of blockchain in managing health records, tracing, and securing medical supplies.• Focuses on efficient and secure medical data sharing through blockchain and secure cloud-based electronic health record (EHR), a system using an attribute-based cryptosystem.• Presents techniques and methods to utilize blockchain technology for clinical studies and facilitates the transition to patient-driven interoperability.The text is primarily written for graduate students and academic researchers in the fields of computer science and engineering, biomedical engineering, electrical engineering, and information technology.

This book addresses the limitations of existing therapeutic approaches using nanoparticles. Emerging Roles of Nanocarriers in Cancer Therapy will further provide information for the development of successful cancer nanomedicine therapies.FeaturesExplains different types of nanoparticles, targeting mechanisms, and approved nanotherapeutics for oncological implications in cancer treatment.Covers in detail the characteristics of various nanotechnology-based drug delivery systems.Discusses passive and active cellular targeting, ligand-based targeting of nanoparticles, and strategies to improve nanoparticle-cellular membrane interaction.Presents the application of nanotherapeutics, current challenges, and prospects, and describes the path of future research.Highlights smart strategies for improving the clinical impact of cancer nanomedicine.The text is primarily written for graduate students, and academic researchers in the fields of biotechnology, nanotechnology, drug delivery, pharmaceutical science, and pharmacology.

This book explores the advanced integration of nanotechnology and biomedicine, providing an in-depth analysis of the transformative impact of carbon nanotubes (CNTs) on healthcare. It provides a comprehensive coverage of the distinctive characteristics of CNTs, including their remarkable mechanical strength, electrical conductivity, and large surface area, which make them very suitable for numerous biomedical uses. The book provides an overview of the process of synthesizing and functionalizing CNTs. It then delves into the specific applications of CNTs in drug delivery systems to improve the effectiveness and targeting of therapeutic agents. Additionally, the book explores the use of CNTs in imaging and diagnostics, enhancing techniques such as MRI and fluorescence imaging. The book also discusses the involvement of CNTs in tissue engineering, namely in the fabrication of scaffolds that facilitate cell growth and tissue regeneration. It explores the application of CNTs in biosensors, where their high sensitivity enables early and accurate identification of diseases. Antibacterial characteristics of CNTs are reviewed in order to hinder infections in medical devices and implants. The potential of CNTs in gene therapy to enhance genetic treatments is also explored in the book. It addresses the concerns related to the toxicity, biocompatibility, and regulatory issues of CNTs. It carefully balances the promising potential of CNTs with the practical implications of their usage in the field of biomedicine. This book is indispensable for researchers, doctors, and individuals with an interest in the cutting-edge utilisation of nanotechnology in the field of medicine.

DEEP LEARNING FOR TREATMENTS The book provides the direction for future research in deep learning in terms of its role in targeted treatment, biological systems, site-specific drug delivery, risk assessment in therapy, etc. Deep Learning for Targeted Treatments describes the importance of the deep learning framework for patient care, disease imaging/detection, and health management. Since deep learning can and does play a major role in a patient’s healthcare management by controlling drug delivery to targeted tissues or organs, the main focus of the book is to leverage the various prospects of the DL framework for targeted therapy of various diseases. In terms of its industrial significance, this general-purpose automatic learning procedure is being widely implemented in pharmaceutical healthcare. AudienceThe book will be immensely interesting and useful to researchers and those working in the areas of clinical research, disease management, pharmaceuticals, R&D formulation, deep learning analytics, remote healthcare management, healthcare analytics, and deep learning in the healthcare industry.

The first book of its kind to show the potential of quantum computing in drug delivery. Drug delivery systems (DDS) are defined as methods by which drugs are delivered to desired tissues, organs, cells, and subcellular organs for drug release and absorption through a variety of drug carriers. By controlling the precise level and/or location of a given drug in the body, side effects are reduced, doses are lowered, and new therapies are possible. Nevertheless, there are still significant obstacles to delivering certain medications to particular cells. Drug delivery methods change pharmacokinetic, pharmacodynamic, and drug release patterns to enhance product efficacy and safety, as well as patient convenience and compliance. Computational approaches in drug development enable quick screening of a vast chemical library and identification of possible binders by using modeling, simulation, and visualization tools. Quantum computing (QC) is a fundamentally new computing paradigm based on quantum mechanics rules that enables certain computations to be conducted significantly more rapidly and effectively than regular computing, and hence this has huge promise for the pharmaceutical sector. Significant advances in computational simulation are making it easier to comprehend the process of drug delivery. This book explores an important biophysical component of DDSs, and how computer modeling may help with the logical design of DDSs with enhanced and optimized characteristics. The book concentrates on computational research for various important types of nanocarriers, including dendrimers and dendrons, polymers, peptides, nucleic acids, lipids, carbon-based DDSs, and gold nanoparticles. Audience Researchers and industry scientists working in clinical research and disease management; pharmacists, formulation and pharmaceutical scientists working in R&D; computer science engineers applying deep learning and quantum computing in healthcare.

INTEGRATION OF BIOMATERIALS FOR GENE THERAPY Brings industrial practitioners and researchers together to discuss how the deeper integration of biomaterial platforms could play a significant role in enabling breakthroughs in the application of gene editing for the treatment of human disease. This book comprises research and review articles from leading researchers with multidisciplinary experience. It discusses many broad topics, including nanoparticle-enabled gene therapy, inorganic nanocarrier-based gene delivery, non-viral delivery of nucleic acid, biocompatible hydrogels, silk, and polysaccharides-based gene delivery. Other gene delivery topics discussed include the use of smart and engineered biomaterials, combined therapy with growth factors and cell transportation, and the prospects and challenges in the treatment of different diseases, including cancer. This book bridges the knowledge of pharmaceutics, engineering, basic science, and clinical research fields in a way that will help the research community expedite the clinical application of these therapies for various diseases and conditions. Audience A broad range of researchers, scientists, and engineers in diverse fields such as materials science, biomedicine, biomedical engineering, biology, chemistry, physics, biotechnology, pharmacology, toxicology, and formulation scientists.

HUMAN-MACHINE INTERFACE The book contains the latest advances in healthcare and presents them in the frame of the Human-Machine Interface (HMI). The Human-Machine Interface (HMI) industry has witnessed the evolution from a simple push button to a modern touch-screen display. HMI is a user interface that allows humans to operate controllers for machines, systems, or instruments. Most medical procedures are improved by HMI systems, from calling an ambulance to ensuring that a patient receives adequate treatment on time. This book describes the scenario of biomedical technologies in the context of the advanced HMI, with a focus on direct brain-computer connection. The book describes several HMI tools and related techniques for analyzing, creating, controlling, and upgrading healthcare delivery systems, and provides details regarding how advancements in technology, particularly HMI, ensure ethical and fair use in patient care. Audience The target audience for this book is medical personnel and policymakers in healthcare and pharmaceutical professionals, as well as engineers and researchers in computer science and artificial intelligence.

The book offers a comprehensive, interdisciplinary overview of how innovative soft materials are revolutionizing biosensing technologies, making it an essential read for anyone interested in cutting-edge advancements in biomedical research and healthcare. Soft materials include granular materials, foams, gels, polymers, surfactants, functional organics, and biological molecules. These structures can be altered by thermal or mechanical stress due to their ability to self-organize into mesoscopic physical structures. They are becoming increasingly significant as functional materials for broader applications because of their rich surface chemistry and versatile functions. A biosensor is an analytical tool for chemical compound detection that combines a biological element with a physicochemical detector. Sensitive biological components, such as proteins, carbohydrates, tissue, bacteria, and enzymes, are collected from a biomimetic element that interacts and binds with the analyte under investigation. In biosensors, soft matter may function as both a sensing and transducing component. The interplay of soft matter with biomolecular analytes results in cell signaling pathways, diagnostic tests for applications in low-resource environments, prospective drug development, molecular biodetection, chemical sensors, and biological sensors. Understanding these biomolecular interactions in the context of acute illnesses is critical for biomedical research and healthcare. This has fueled efforts to create a biosensor that is effective, low-cost, and label-free. Several approaches using soft materials to functionalize and tailor structures have greatly advanced science, including chemistry, physics, pharmaceutical science, materials science, and engineering. Soft Materials-Based Biosensing Medical Applications summarizes recent advances in soft materials with unique physicochemical properties that synergistically promote biosensing systems. Audience The book will be read by researchers, materials scientists, electronic and AI engineers, as well as pharmaceutical and biomedical professionals interested in the uses of biosensing.

This book presents the fundamentals of explainable artificial intelligence (XAI) and responsible artificial intelligence (RAI), discussing their potential to enhance diagnosis, treatment, and patient outcomes. This book explores the transformative potential of explainable artificial intelligence (XAI) and responsible AI (RAI) in healthcare. It provides a roadmap for navigating the complexities of healthcare-based AI while prioritizing patient safety and well-being. The content is structured to highlight topics on smart health systems, neuroscience, diagnostic imaging, and telehealth. The book emphasizes personalized treatment and improved patient outcomes in various medical fields. In addition, this book discusses osteoporosis risk, neurological treatment, and bone metastases. Each chapter provides a distinct viewpoint on how XAI and RAI approaches can help healthcare practitioners increase diagnosis accuracy, optimize treatment plans, and improve patient outcomes. Readers will find the book: explains recent XAI and RAI breakthroughs in the healthcare system;discusses essential architecture with computational advances ranging from medical imaging to disease diagnosis;covers the latest developments and applications of XAI and RAI-based disease management applications; demonstrates how XAI and RAI can be utilized in healthcare and what problems the technology faces in the future. AudienceThe main audience for this book is targeted to scientists, healthcare professionals, biomedical industries, hospital management, engineers, and IT professionals interested in using AI to improve human health.

Blockchain in healthcare is a recent breakthrough and is redefining the information architecture that underpins all healthcare services. Blockchain can make health information systems safer, more efficient, more accessible, and more dependable. This new book introduces the basic concepts of blockchain in relation to the healthcare sector and offers solutions for enhanced healthcare services, management, and administration.The book deals with the use of blockchain in remotely monitoring patients, in creating medical contracts, and in enhancing data transmission security in healthcare. It covers the role of blockchain in patient selection and treatment strategies, in tracking diseases and pandemics, in managing supply chains, and in the health insurance sector. Finally, the book also presents the challenges that may occur due to digital transformation and looks at how blockchain technology can transform healthcare in the future.Creating Smart Healthcare with Blockchain and Advanced Digital Technology is a comprehensive book that explores different aspects of blockchain in revolutionizing healthcare. It will be especially useful for researchers, medical personnel, academicians, industrial practitioners, and students in IT and healthcare.

Extensive attempts for developing cancer vaccines over the last 50 years have been made, but with minimal success. The current research in genetics, molecular biology, biochemistry, and immunology has revived interest in these immunotherapies and enabled the development of potential cancer vaccine candidates. This book, Cancer Vaccination and Challenges, in two volumes, deals with the very relevant issue of cancer vaccines and the various challenges their development and delivery present.Volume 1: Different Strategies for Therapeutic Cancer Vaccine Development deals with different strategies of cancer vaccine development. The primary focus of this volume is the techniques for the development of therapeutic cancer vaccines. It helps clarify the current need for vaccines in cancer treatment, exploring deeper information such as the roles of tumor antigens, proteins/peptides, microbial genes, and stem cells for the development of vaccines for cancer management. The volume also provides latest insights on DNA- and RNA-based cancer vaccines, eventually covering the regulatory perspectives for the cancer vaccine developments.Volume 2: Delivery Strategies for Cancer Vaccine and Immunotherapy in Management of Various Carcinomas presents an understanding of delivery strategies of cancer vaccines for the management of various forms of carcinoma. It discusses the management of various carcinomas using vaccines, examining the prospects of delivering immuno-oncology therapies, focusing specifically on the affective drug delivery strategies for treatment of lung, prostate, and pancreatic carcinomas. The volume provides an overview of the current vaccine systems, adjuvants, and delivery methods that are being explored or have been approved. It also focuses on therapeutic cancer vaccines that could be used to prevent the spread of advanced malignancies that are resistant to standard treatments, including surgery, radiation therapy, and chemotherapy.This two-volume book will be a valuable resource for researchers with a pharmaceutical background and professionals working in the field of biomedical science, engineering, vaccine development, and cancer therapy.

Volume 1: Strategies for Therapeutic Cancer Vaccine Development deals with different strategies of cancer vaccine development, focusing on techniques for the development of therapeutic cancer vaccines and the roles of tumor antigens, proteins/peptides, microbial genes, and stem cells for the development of vaccines for cancer management. Volume 2: Delivery Strategies for Cancer Vaccine and Immunotherapy in Management of Various Carcinomas covers delivery strategies of cancer vaccines for the management of various forms of carcinoma, examining the prospects of delivering immuno-oncology therapies, focusing specifically on the effective drug delivery strategies for treatment of lung, prostate, and pancreatic carcinomas.

Volume 1: Strategies for Therapeutic Cancer Vaccine Development deals with strategies of cancer vaccine development, focussing on the techniques for the development of therapeutic cancer vaccines and the role of tumor antigens, proteins/peptides, microbial genes, and stem cells for the development of vaccines for cancer management. .Volume 2: Delivery Strategies for Cancer Vaccine and Immunotherapy in Management of Various Carcinomas covers delivery strategies of cancer vaccines for the management of various forms of carcinoma, examining the prospects of delivering immuno-oncology therapies, focusing specifically on effective drug delivery strategies for the treatment of lung, prostate, and pancreatic carcinomas.

Neurological illnesses pose one of the biggest hazards to the healthcare system today. This new book brings together the latest methods of gene therapy that can be used to treat both inherited and sporadic neurodegenerative diseases. It presents the most significant advances in gene transfer methods as well as the most recent understandings of the mechanisms behind specific neurodegenerative illnesses, placing these into the context of gene therapy approaches for the central nervous system. The book introduces the basics of neurodegenerative conditions and the physiological basis for their occurrence in humans. It also discusses the various proteins useful in neuro diseases and their viral applications. The book explores how stem cells can be used to learn about the future of gene therapy along with the significance of the sequences that silence genes. It discusses the functions of astrocytes in different brain regions, as well as in-vivo research in gene therapy for neurodegenerative disorders.

Metals have been used for health and healing for thousands of years. Today, the use of metal complexes as medicinal substances is becoming more and more significant as inorganic chemistry evolves. This book, Metals in Medicine, set in two volumes, provides detailed information on and applications of metal-containing compounds that function as essential tools in medical science for the imaging and diagnosis of disease as well as for the prevention and treatment of many diseases.Volume 1: Metals for Tissue Engineering and Pharmaceutical Applications introduces metallodrugs and their applications in the biomedical field, including for tissue engineering, drug delivery, bioimaging, biosensing, and bone tissue engineering. Volume 2: Metallic Nanoparticles for Biomedical Applications illustrates the possible applications of different types of metal-based drugs in the pharmaceutical and biomedical fields.In Volume 1, a curated collection of the latest medicinal and inorganic chemical research featuring metals for medicinal applications is presented. The book covers the use of metallic foams, metallic nanocarriers, metal organic frameworks of bioimaging and biosensing application, metallic scaffolds for tissue engineering, and much more. The volume presents the valuable therapeutic and diagnostic properties of metallic drugs, connecting the fields of inorganic chemistry and medicine.Volume 2 deals with the application of particular metal-active drugs for disease treatment and diagnosis. It presents the compounds/complexes that have been found to be promising for potential therapeutic use along with their properties and the diseases against which they could be effective. It explores the application of gold and silver nanoparticles for tissue engineering as well as their role in cancer therapy. In addition, it employs real-life applications of metallic drugs that include gold- and zinc-based nanosystems in cancer therapy, zinc oxide in disease diagnosis, gold/silver nanoparticles for tissue engineering and biomedical applications, palladium in photothermal therapy for cancer, etc. This volume gives a comprehensive and thorough analysis of the use of metal complexes in medicine.This two-volume resource will serve as a reference for professionals, faculty and graduate students, and postdoctoral researchers in the fields of materials science, biomedical engineering, and metallo-engineering. It is a valuable resource for academic and industrial scientists working in inorganic chemistry, medicinal chemistry, and drug discovery.

Metals in Medicine, published in two volumes, provides detailed information on and applications of metal-containing compounds that function as essential tools in medical science for the imaging and diagnosis of disease as well for the prevention and treatment of many diseases. Volume 1 offers a curated collection of the latest medicinal and inorganic chemical research featuring metals for medicinal applications. It covers the use of metallic foams, metallic nanocarriers, metal organic frameworks of bioimaging and biosensing application, metallic scaffolds for tissue engineering, and much more. The volume also presents the valuable therapeutic and diagnostic properties of metallic drugs, connecting the fields of inorganic chemistry and medicine.Volume 2: Metallic Nanoparticles for Biomedical Applications deals with the application of particular metal-active drugs for disease treatment and diagnosis, presenting the compounds/complexes that have been found to be promising for potential therapeutic use along with their properties.

Metals in Medicine, published in two volumes, provides detailed information on and applications of metalcontaining compounds that function as essential tools in medical science for the imaging and diagnosis of disease as well for the prevention and treatment of many diseases. Volume 2 deals with the application of metal-active drugs for disease treatment and diagnosis. It explores the application of gold, silver, zinc, and other metallic nanoparticles for tissue engineering as well as their role in cancer therapy, offering real-life applications.Volume 1: Metals for Tissue Engineering and Pharmaceutical Applications introduces metallodrugs and their applications in the biomedical field, including for tissue engineering, drug delivery, bioimaging, biosensing, and bone tissue engineering.

This new book explores the dynamic integration of soft robotics and biomedical sciences, emphasizing a human-centered approach on how soft robotic technologies may fundamentally alter the healthcare sector, from personalized treatment to cutting-edge medical equipment. The chapters discuss soft robotics in implanted devices and artificial muscles and robotics for limb design and their potential to improve mobility and overall quality of life. The use of innovative soft actuators and advancements in sensors for healthcare applications is considered, and the book also looks at naturally inspired designs that allow robotic systems to carefully interact with biological things.

The revolutionary capabilities of the use of graft copolymers of polysaccharides in tissue engineering and biomedical applications are explored in this new volume, covering their production, uses, and future directions. Graft copolymers are innovative materials that show enormous potential for combating many healthcare issues.This book demonstrates an immense range of possible potentials, presenting groundbreaking work on chitosan-based graft copolymers as well as cutting-edge research on graft polysaccharides as excipients for solid dosage forms. The topics explore green-synthesized nanobactericides and the use graft polymers to formulate nanoparticles, highlighting the ways that nanotechnology and environmental consciousness are influencing this discipline.Detailed discussions on improving biodegradability, biocompatibility, and the development of smart hydrogels are included as well as research on bone marrow regeneration applications, demonstrating the significant role that graft copolymers play in enabling innovative biomedical solutions.Exploring the vast potential that polysaccharide-based graft copolymers have in biomedical and tissue engineering applications, this volume will be a valuable resource for biomedical specialists, clinical practitioners, pharmaceutical scientists, and medical experts.

“This comprehensive collection gathers together a plethora of information... on the connection between polymer science and biomedical applications. Graft copolymers of polysaccharides have shown remarkable expansion in recent decades due to the demand for innovative ways to deliver drugs, better therapeutic efficacy, and advanced biomedical technology. This book presents a wide range of information, from the design and synthesis of polysaccharide graft copolymers to their biomedical and pharmaceutical applications.... It starts by going through the fundamental principles and techniques used to synthesize polysaccharide graft copolymers. The chapters explore applications of polysaccharide graft copolymers in therapeutic drug delivery, reliable dose formulations, and the fascinating possibilities in the formulation of nanoparticulate systems. The synthesis and utilization of chitosan-based graft copolymers are also highlighted in the book; this subject is of great importance to the biomedical industry.”—From the Foreword by Dr. Dhruv Galgotia, CEO, Galgotias University, Greater Noida, India

One of the most novel and promising strategies in medical research and the fight against cancer is the combination of DNA and messenger RNA vaccines. This new book explores the therapeutic uses, the biological processes, and the difficulties related to this novel strategy for cancer immunotherapy. Offering a unique perspective on different facets of DNA- and mRNA-based cancer vaccines, the authors present a thorough overview of the constantly changing field of cancer immunotherapy, from explaining the unique aspects of tumor angiogenesis and the role that non-coding RNAs play in treatment resistance, to investigating the most recent developments in gene therapy and splicing control. The volume also looks at this fascinating field’s future potential, giving cancer patients hope for less intrusive and more effective therapies.

Excipients are important components of drug formulations, playing a critical role in ensuring the safety, efficacy, and stability of pharmaceutical products. In recent years, there has been a growing demand for advanced drug delivery systems that can improve the bioavailability, targeting, and sustained release of therapeutics. The development of these systems relies heavily not only on excipients but also on the use of processed excipients, which have been specifically designed and engineered to meet the unique challenges and requirements of advanced drug delivery.This new volume provides a comprehensive overview of the state-of-art research on processed excipients and their utilization in fabrication of advanced drug delivery. Beginning with an introduction and overview, the volume covers novel solid dosage forms, pharmaceutical and biomedical applications, nasal drug delivery, ocular drug delivery, transdermal drug delivery, parenteral medication delivery, pharmacokinetics and pharmacodynamics of processed excipients, and much more.