Stephen Holgate – författare

The increasing incidence and prevalence of allergic disease worldwide is one of the most remarkable phenomena of the past 50 years. One in three people in developed countries will experience an allergic condition at some point in their lives and advances in understanding the causes of this trend, and in allergy treatment and care, have captured the imagination of scientists, clinicians and the public.Landmark Papers in Allergy is a definitive collection of over 90 papers charting key discoveries and scientific advances in relation to allergy and the development of treatment and care for allergic disorders. Comprehensive in its coverage, the book includes the first clear descriptions of allergic diseases; the major advances in treatments, such as the discovery of antihistamines, cortisone, biological therapies and immunotherapy; the great immunological advances, such as the discovery of immunoglobulin E (IgE) and leukotrienes; the possible factors behind the increase in allergy, such as the house dust mite, changes in hygiene and diet; and the growing understanding of the social, psychological and quality-of-life consequences of allergy. Including authoritative commentaries from leading international experts providing reflections on the historical importance and current relevance of each landmark paper, Landmark papers in Allergy is essential reading for any clinician or academic with an interest in allergy.

This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies. Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthmadescribes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis and more! Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.

This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies. Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthma

describes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis and more! Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.

This timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies. Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthma

describes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis and more! Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.

"e;Once this one has you in its grip, it never lets go."e; -Steve Berry, New York Times bestselling writer of The Atlas Maneuver"e;[A] twisty tale of honor, deception, and bygone love."e; -Matt Coyle, author of the bestselling Rick Cahill crime seriesYou don't ignore a man's dying wish.Retired diplomat Sam Hough boards a transatlantic flight to Paris after making a seemingly innocent promise to find the five-year-old son of a dying friend, a son the friend has never known.With only the thinnest of clues, Sam quickly realizes that those who agree to help him soon disappear, those who don't disappear refuse to help him, and still others want to kill him rather than help find the boy. Clearly there are things his friend neglected to tell him. But what did he leave out-and why?Sam's search through the narrow streets of the great city's seamiest neighborhoods leads him into a maze of suspicion, betrayal, and growing danger-and to the rekindling of a long-lost romance.In its shadows, the city of light holds deadly secrets. Sam must race to resolve his mysterious quest before his promise turns into an epitaph.For listeners who enjoy thrillers by Graham Greene, John Le Carre, and Jack Slater.

"e;Once this one has you in its grip, it never lets go."e; -Steve Berry, New York Times bestselling writer of The Atlas Maneuver"e;[A] twisty tale of honor, deception, and bygone love."e; -Matt Coyle, author of the bestselling Rick Cahill crime seriesYou don't ignore a man's dying wish.Retired diplomat Sam Hough boards a transatlantic flight to Paris after making a seemingly innocent promise to find the five-year-old son of a dying friend, a son the friend has never known.With only the thinnest of clues, Sam quickly realizes that those who agree to help him soon disappear, those who don't disappear refuse to help him, and still others want to kill him rather than help find the boy. Clearly there are things his friend neglected to tell him. But what did he leave out-and why?Sam's search through the narrow streets of the great city's seamiest neighborhoods leads him into a maze of suspicion, betrayal, and growing danger-and to the rekindling of a long-lost romance.In its shadows, the city of light holds deadly secrets. Sam must race to resolve his mysterious quest before his promise turns into an epitaph.For listeners who enjoy thrillers by Graham Greene, John Le Carre, and Jack Slater.