Steven Gray – författare

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector.

The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver).

The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.

Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector.The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver).The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.- Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas- Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications- Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs

Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, along with new discoveries to improve our understanding of cancer epigenetics and therapeutics. The book encompasses large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use.

Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically, with increasing evidence linking pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering.

Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, thus demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs Provides a fully updated resource on new topics, including the epitranscriptome, oncohistones, single cell analysis, epigenetic priming, CRISPR therapy, CAR-T therapy, and epigenetics and pollution Features chapter contributions from leading experts in the field

Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, along with new discoveries to improve our understanding of cancer epigenetics and therapeutics. The book encompasses large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use.Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically, with increasing evidence linking pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering.- Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies- Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, thus demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs- Provides a fully updated resource on new topics, including the epitranscriptome, oncohistones, single cell analysis, epigenetic priming, CRISPR therapy, CAR-T therapy, and epigenetics and pollution- Features chapter contributions from leading experts in the field

This book examines how the expansion of a steam-powered Royal Navy from the second half of the nineteenth century had wider ramifications across the British Empire. In particular, it considers how steam propulsion made vessels utterly dependent on a particular resource – coal – and its distribution around the world. In doing so, it shows that the ‘coal question’ was central to imperial defence and the protection of trade, requiring the creation of infrastructures that spanned the globe. This infrastructure required careful management, and the processes involved show the development of bureaucracy and the reliance on the ‘contractor state’ to ensure this was both robust and able to allow swift mobilisation in war. The requirement to stop regularly at foreign stations also brought men of the Royal navy into contact with local coal heavers, as well as indigenous populations and landscapes. These encounters and their dissemination are crucial to our understanding of imperial relationshipsand imaginations at the height of the imperial age.

This book examines how the expansion of a steam-powered Royal Navy from the second half of the nineteenth century had wider ramifications across the British Empire. In particular, it considers how steam propulsion made vessels utterly dependent on a particular resource – coal – and its distribution around the world. In doing so, it shows that the ‘coal question’ was central to imperial defence and the protection of trade, requiring the creation of infrastructures that spanned the globe. This infrastructure required careful management, and the processes involved show the development of bureaucracy and the reliance on the ‘contractor state’ to ensure this was both robust and able to allow swift mobilisation in war. The requirement to stop regularly at foreign stations also brought men of the Royal navy into contact with local coal heavers, as well as indigenous populations and landscapes. These encounters and their dissemination are crucial to our understanding of imperial relationshipsand imaginations at the height of the imperial age. 

This volume brings together, in a central text, chapters written by leading scholars working at the intersection of modeling, the natural and social sciences, and public participation. This book presents the current state of knowledge regarding the theory and practice of engaging stakeholders in environmental modeling for decision-making, and includes basic theoretical considerations, an overview of methods and tools available, and case study examples of these principles and methods in practice. Although there has been a significant increase in research and development regarding participatory modeling, a unifying text that provides an overview of the different methodologies available to scholars and a systematic review of case study applications has been largely unavailable. This edited volume seeks to address a gap in the literature and provide a primer that addresses the growing demand to adopt and apply a range of modeling methods that includes the public in environmental assessment and management.The book is divided into two main sections. The first part of the book covers basic considerations for including stakeholders in the modeling process and its intersection with the theory and practice of public participation in environmental decision-making. The second part of the book is devoted to specific applications and products of the various methods available through case study examination. This second part of the book also provides insight from several international experts currently working in the field about their approaches, types of interactions with stakeholders, models produced, and the challenges they perceived based on their practical experiences.

This volume brings together, in a central text, chapters written by leading scholars working at the intersection of modeling, the natural and social sciences, and public participation. This book presents the current state of knowledge regarding the theory and practice of engaging stakeholders in environmental modeling for decision-making, and includes basic theoretical considerations, an overview of methods and tools available, and case study examples of these principles and methods in practice. Although there has been a significant increase in research and development regarding participatory modeling, a unifying text that provides an overview of the different methodologies available to scholars and a systematic review of case study applications has been largely unavailable. This edited volume seeks to address a gap in the literature and provide a primer that addresses the growing demand to adopt and apply a range of modeling methods that includes the public in environmental assessment and management.The book is divided into two main sections. The first part of the book covers basic considerations for including stakeholders in the modeling process and its intersection with the theory and practice of public participation in environmental decision-making. The second part of the book is devoted to specific applications and products of the various methods available through case study examination. This second part of the book also provides insight from several international experts currently working in the field about their approaches, types of interactions with stakeholders, models produced, and the challenges they perceived based on their practical experiences.