Steven M. Powell – författare

Otorhinolaryngology-head and neck surgery (ORL-HNS) is a surgical subspeciality that affects all age groups and covers a wide range of pathologies and treatments from the commonest of conditions seen in primary care to some of the rarest, requiring tertiary investigation and state of the art treatments. This makes it difficult for those training and working in ORL-HNS and its allied specialities to learn about and keep up to date with all its component parts. The Oxford Textbook of Otolaryngology provides a solution. A comprehensive guide to all aspects of the speciality, the textbook covers all the knowledge that clinicians from all subspecialties of otolaryngology requires to keep abreast of current practice, with a strong emphasis on evidence-based practice.The textbook is divided into sections on Otology and Audiology, Rhinology, Head and Neck Surgery and Paediatric Otolaryngology. These sections are then further divided into two broad sub-sections: the first covering common presenting symptoms and signs, and the second covering specific conditions. The introductory chapters of this book aim to provide insight into emerging aspects of medicine that are essential for the day-to-day practice of otolaryngology before moving on to the more specific areas highlighted. The textbook is the perfect resource to aid an otolaryngology trainee in passing key examinations while also suitable for established specialists to help remain up to date and to meet the necessary requirements for revalidation.

Steven M. Powell, MD, has assembled a hands-on collection of cutting-edge molecular methods for studying colorectal tumors. These readily reproducible techniques range from gross microdissection of specimens to specific molecular analyses. Here both the novice and experienced researcher will find productive chromosomal analyses, including comparative genomic hybridization and FISH assays, and revealing gene expression analyses, including immunohistochemical assays, Western blotting, and microarray assays. Eminently practical, with each technique presented as if the expert in the field who had perfected it were guiding the investigator, Colorectal Cancer: Methods and Protocols provides cancer investigators with a gold standard collection of all the key genetic, cellular, and molecular biological methods for analyzing colon cancer today.

The contents of Colorectal Cancer: Methods and Protocols aim to instruct investigators in all the key genetic, cellular, and molecular biological methods of analyzing colorectal tumors. The focused techniques and assays are described in sufficient detail to allow researchers to start an experiment on colon tumors and proceed from beginning to end as if the expert in the field who has performed these studies were guiding them at the bench. Of note, most of the chapters in this volume are written by those scientists who p- neered these methods and assays in their respective fields. The chapters in Colorectal Cancer: Methods and Protocols describe “state of the art” methods to analyze colorectal tumors, ranging from gross mic- dissection of specimens to specific molecular analyses. Included are coverages of mutational assays, instability testing, immunohistochemical assays, chro- somal studies, and gene expression analyses. The goal of our volume is to facilitate the performance of colorectal tumor biological experiments by investigators at various levels of training—from graduate students and postdoctoral fellows to principal investigators who desire to advance our understanding of colon cancer development.