Susan A Masino – författare

Ketogenic diets have been used to successfully treat epilepsy and stop seizures for nearly a century. When more traditional therapies, such as pharmacology, reach their limitations for treatment, the metabolic approach surpasses, targeting the overall physiology and homeostatic functions of the patient. Ketogenic Diet and Metabolic Therapies is the first comprehensive scientific resource on the ketogenic diet, covering the latest research including the biomedical mechanisms, established and emerging applications, metabolic alternatives, and implications for health and disease. Experts in clinical and basic research share their research into mechanisms spanning from ion channels to epigenetics, their insights based on decades of experience with the ketogenic diet in epilepsy, and their evidence for emerging applications ranging from autism to Alzheimer''s disease to brain cancer. Research in metabolic therapies has spread into laboratories and clinics of every discipline, and is yielding to entirely new classes of drugs and treatment regimens.The book''s editor, Susan A. Masino, brings her unique expertise in clinical and research neurology to the overall scope of this work. To further enhance the scope and quality of this one of a kind book, section editors Eric Kossoff, Jong Rho, Detlev Boison, and Dominic P. D''Agostino lend their oversight on their respective sections.

Ketogenic diets have been used to successfully treat epilepsy and stop seizures for nearly a century. When more traditional therapies, such as pharmacology, reach their limitations for treatment, the metabolic approach surpasses, targeting the overall physiology and homeostatic functions of the patient. Ketogenic Diet and Metabolic Therapies is the first comprehensive scientific resource on the ketogenic diet, covering the latest research including the biomedical mechanisms, established and emerging applications, metabolic alternatives, and implications for health and disease. Experts in clinical and basic research share their research into mechanisms spanning from ion channels to epigenetics, their insights based on decades of experience with the ketogenic diet in epilepsy, and their evidence for emerging applications ranging from autism to Alzheimer''s disease to brain cancer. Research in metabolic therapies has spread into laboratories and clinics of every discipline, and is yielding to entirely new classes of drugs and treatment regimens.The book''s editor, Susan A. Masino, brings her unique expertise in clinical and research neurology to the overall scope of this work. To further enhance the scope and quality of this one of a kind book, section editors Eric Kossoff, Jong Rho, Detlev Boison, and Dominic P. D''Agostino lend their oversight on their respective sections.

Ketogenic diets have treated epilepsy for nearly 100 years, yet metabolic therapy has remained obscure and underutilized for most of this time. In recent decades, the clinical efficacy of ketogenic therapy was confirmed definitively for pediatric epilepsy and has now expanded to adult epilepsy. Now, the benefits of metabolic therapy have been extended well beyond epilepsy to additional neurological, metabolic, and genetic disorders, and the importance of metabolic health is recognized as paramount. This new edition of Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease highlights the growing research and clinical applications of metabolic therapies as effective in disease treatment, reversal and prevention. Emerging mechanisms include the landscape of the microbiome and epigenetics. Consistent with the first observations in 1921, in some cases metabolism-based strategies have proven equal or superior to pharmacological treatments for specific diseases and for treating multiple comorbidities. This second edition commemorates the 100th anniversary of the ketogenic diet, shares new research in this rapidly moving field, and offers a valuable collection of high-resolution color figures. The team of editors for this edition have been working in this area for decades, and in this volume, they have assembled world leaders in this cutting-edge research. As the first academic, interdisciplinary book on ketogenic diet and metabolic therapy, this volume will be crucial during this time of increased appreciation for metabolic health in professionals and the public alike.

Ketogenic diets have treated epilepsy for nearly 100 years, yet metabolic therapy has remained obscure and underutilized for most of this time. In recent decades, the clinical efficacy of ketogenic therapy was confirmed definitively for pediatric epilepsy and has now expanded to adult epilepsy. Now, the benefits of metabolic therapy have been extended well beyond epilepsy to additional neurological, metabolic, and genetic disorders, and the importance of metabolic health is recognized as paramount.This new edition of Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease highlights the growing research and clinical applications of metabolic therapies as effective in disease treatment, reversal and prevention. Emerging mechanisms include the landscape of the microbiome and epigenetics. Consistent with the first observations in 1921, in some cases metabolism-based strategies have proven equal or superior to pharmacological treatments for specific diseases and for treating multiple comorbidities.This second edition commemorates the 100th anniversary of the ketogenic diet, shares new research in this rapidly moving field, and offers a valuable collection of high-resolution color figures. The team of editors for this edition have been working in this area for decades, and in this volume, they have assembled world leaders in this cutting-edge research. As the first academic, interdisciplinary book on ketogenic diet and metabolic therapy, this volume will be crucial during this time of increased appreciation for metabolic health in professionals and the public alike.

Ketogenic diets have treated epilepsy for nearly 100 years, yet metabolic therapy has remained obscure and underutilized for most of this time. In recent decades, the clinical efficacy of ketogenic therapy was confirmed definitively for pediatric epilepsy and has now expanded to adult epilepsy. Now, the benefits of metabolic therapy have been extended well beyond epilepsy to additional neurological, metabolic, and genetic disorders, and the importance of metabolic health is recognized as paramount.This new edition of Ketogenic Diet and Metabolic Therapies: Expanded Roles in Health and Disease highlights the growing research and clinical applications of metabolic therapies as effective in disease treatment, reversal and prevention. Emerging mechanisms include the landscape of the microbiome and epigenetics. Consistent with the first observations in 1921, in some cases metabolism-based strategies have proven equal or superior to pharmacological treatments for specific diseases and for treating multiple comorbidities.This second edition commemorates the 100th anniversary of the ketogenic diet, shares new research in this rapidly moving field, and offers a valuable collection of high-resolution color figures. The team of editors for this edition have been working in this area for decades, and in this volume, they have assembled world leaders in this cutting-edge research. As the first academic, interdisciplinary book on ketogenic diet and metabolic therapy, this volume will be crucial during this time of increased appreciation for metabolic health in professionals and the public alike.

Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer's or Parkinson's are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health.Key Features include· A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks.· Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise.· Incorporation of homeostatic therapies into existing basic and clinical research paradigms.· Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis.· Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.

Homeostatic Control of Brain Function offers a broad view of brain health and diverse perspectives for potential treatments, targeting key areas such as mitochondria, the immune system, epigenetic changes, and regulatory molecules such as ions, neuropeptides, and neuromodulators. Loss of homeostasis becomes expressed as a diverse array of neurological disorders. Each disorder has multiple comorbidities - with some crossing over several conditions - and often disease-specific treatments remain elusive. When current pharmacological therapies result in ineffective and inadequate outcomes, therapies to restore and maintain homeostatic functions can help improve brain health, no matter the diagnosis. Employing homeostatic therapies may lead to future cures or treatments that address multiple comorbidities. In an age where brain diseases such as Alzheimer''s or Parkinson''s are ever present, the incorporation of homeostatic techniques could successfully promote better overall brain health.Key Features include· A focus on the homeostatic controls that significantly depend on the way one lives, eats, and drinks.· Highlights from emerging research in non-pharmaceutical therapies including botanical medications, meditation, diet, and exercise.· Incorporation of homeostatic therapies into existing basic and clinical research paradigms.· Extensive scientific basic and clinical research ranging from molecules to disorders. · Emerging practical information for improving homeostasis.· Examples of homeostatic therapies in preventing and delaying dysfunction. Both editors, Detlev Boison and Susan Masino, bring their unique expertise in homeostatic research to the overall scope of this work. This book is accessible to all with an interest in brain health; scientist, clinician, student, and lay reader alike.