T. Christian Gasser – författare

This textbook serves as a modern introduction to vascular biomechanics and provides the comprehensive overview of the entire vascular system that is needed to run successful vascular biomechanics simulations. It aims to provide the reader with a holistic analysis of the vascular system towards its biomechanical description and includes numerous fully through-calculated examples. Various topics covered include vascular system descriptions, vascular exchange, blood vessel mechanics, vessel tissue characterization, blood flow mechanics, and vascular tissue growth and remodeling. This textbook is ideally suited for students and researchers studying and working in classical and computational vascular biomechanics. The book could also be of interest to developers of vascular devices and experts working with the regulatory approval of biomedical simulations.Follows the principle of “learning by doing” and provides numerous fully through-calculated examples for active learning, immediate recall, and self-examination;Provides a holistic understanding of vascular functioning and the integration of information from different disciplines to enable students to use sophisticated numerical methods to simulate the response of the vascular system;Includes several case studies that integrate the presented material. Case studies address problems, such as the biomechanical rupture risk assessment of Abdominal Aortic Aneurysms, Finite Element analysis of structural and blood flow problems, the computation of wall stress and wall shear stress in the aorta.

As biomechanics is fundamental to understanding the normal and pathological functions of the aorta, Biomechanics of the Aorta presents a holistic analysis of aortic physiology, clinical imaging, tissue and blood flow modeling. It investigates a wide range of topics from basic sciences (vascular biology, continuum mechanics, image analysis) to essential knowledge for clinical applications, including diagnostics, aortic rupture prediction, as well as surgical planning. Expert chapter authors describe and present computational studies and experimental benches, to mimic, understand and propose the best treatment of aortic pathologies.Divided into five parts, the book begins with an introduction to the fundamental aspects of the anatomy, biology, and physiopathology of the aorta, and then proceeds to present concepts of imaging and tissue/rheology characterization, tissue modeling and rupture, and flow modeling and algorithms. The final part dives into applications and case studies including transcatheter aortic valve implantation, aortic aneurysm rupture prediction, aortic dissections, and pharmacological treatments.

Comprehensive coverage of the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decadeIntroduces the most recent imaging technologies to characterize factors, including aortic geometry, mechanical properties of aortic tissues, and cellular activity in the vessel wallSynthesizes advances in vascular biomechanics, medical imaging, and computational modeling of finite element fluid and solid models

Biomechanics of the Aorta: Modelling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies.The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures.- Comprehensive coverage of the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade- Introduces the most recent imaging technologies to characterize factors, including aortic geometry, mechanical properties of aortic tissues, and cellular activity in the vessel wall- Synthesizes advances in vascular biomechanics, medical imaging, and computational modeling of finite element fluid and solid models

This textbook serves as a modern introduction to vascular biomechanics and provides the comprehensive overview of the entire vascular system that is needed to run successful vascular biomechanics simulations. It aims to provide the reader with a holistic analysis of the vascular system towards its biomechanical description and includes numerous fully through-calculated examples. Various topics covered include vascular system descriptions, vascular exchange, blood vessel mechanics, vessel tissue characterization, blood flow mechanics, and vascular tissue growth and remodeling.

This textbook is ideally suited for students and researchers studying and working in classical and computational vascular biomechanics. The book could also be of interest to developers of vascular devices and experts working with the regulatory approval of biomedical simulations.

Follows the principle of “learning by doing” and provides numerous fully through-calculated examples for active learning, immediate recall, and self-examination;Provides a holistic understanding of vascular functioning and the integration of information from different disciplines to enable students to use sophisticated numerical methods to simulate the response of the vascular system;Includes several case studies that integrate the presented material. Case studies address problems, such as the biomechanical rupture risk assessment of Abdominal Aortic Aneurysms, Finite Element analysis of structural and blood flow problems, the computation of wall stress and wall shear stress in the aorta.

This textbook serves as a modern introduction to vascular biomechanics and provides the comprehensive overview of the entire vascular system that is needed to run successful vascular biomechanics simulations. It aims to provide the reader with a holistic analysis of the vascular system towards its biomechanical description and includes numerous fully through-calculated examples. Various topics covered include vascular system descriptions, vascular exchange, blood vessel mechanics, vessel tissue characterization, blood flow mechanics, and vascular tissue growth and remodeling. This textbook is ideally suited for students and researchers studying and working in classical and computational vascular biomechanics. The book could also be of interest to developers of vascular devices and experts working with the regulatory approval of biomedical simulations.Follows the principle of “learning by doing” and provides numerous fully through-calculated examples for active learning, immediate recall, and self-examination;Provides a holistic understanding of vascular functioning and the integration of information from different disciplines to enable students to use sophisticated numerical methods to simulate the response of the vascular system;Includes several case studies that integrate the presented material. Case studies address problems, such as the biomechanical rupture risk assessment of Abdominal Aortic Aneurysms, Finite Element analysis of structural and blood flow problems, the computation of wall stress and wall shear stress in the aorta.

Dieses Lehrbuch dient als moderne Einführung in die vaskuläre Biomechanik und bietet den umfassenden Überblick über das gesamte Gefäßsystem, der für die Durchführung erfolgreicher vaskulärer biomechanischer Simulationen erforderlich ist. Es zielt darauf ab, dem Leser eine ganzheitliche Analyse des Gefäßsystems in Richtung seiner biomechanischen Beschreibung zu vermitteln und enthält zahlreiche vollständig durchgerechnete Beispiele. Zu den verschiedenen behandelten Themen gehören die Beschreibung des Gefäßsystems, der Gefäßaustausch, die Mechanik der Blutgefäße, die Charakterisierung des Gefäßgewebes, die Mechanik des Blutflusses sowie das Wachstum und der Umbau des Gefäßgewebes.Dieses Lehrbuch ist ideal geeignet für Studenten und Forscher, die sich mit klassischer und rechnerischer vaskulärer Biomechanik beschäftigen. Das Buch könnte auch für Entwickler von vaskulären Geräten und für Experten, die sich mit der Zulassung biomedizinischer Simulationen befassen, von Interesse sein.Folgt dem Prinzip des "learning by doing" und bietet zahlreiche vollständig durchgerechnete Beispiele für aktives Lernen, sofortiges Erinnern und Selbstüberprüfung;Vermittelt ein ganzheitliches Verständnis der Funktionsweise von Gefäßen und die Integration von Informationen aus verschiedenen Disziplinen, um die Studierenden in die Lage zu versetzen, anspruchsvolle numerische Methoden zur Simulation der Reaktion des Gefäßsystems einzusetzen;Enthält mehrere Fallstudien, die das vorgestellte Material integrieren. Die Fallstudien befassen sich mit Problemen wie der biomechanischen Bewertung des Rupturrisikos von Bauchaortenaneurysmen, der Finite-Elemente-Analyse von Struktur- und Blutflussproblemen sowie der Berechnung von Wandspannung und Wandschubspannung in der Aorta.