Tomio Inoue – författare

PET has been a valuable research tool in academic institutions since the ''70s, but its move into clinical practice in community hospitals has just begun. PET has undergone spectacular growth in the fields of nuclear medicine, radiology, and oncology. The burgeoning world of PET is reflected in standing room only CME courses at scientific meetings such as the Radiology Society of North America and the Society for Nuclear Medicine.

This book will provide nuclear medicine practitioners, radiologists, oncologists, and neurologists with a practical overview of the basic principles and clinical applications of PET. Emphasis is placed on the familiarization of normal distribution, artefacts, and common imaging agents such as FDG in conjunction with CT, MRI, and US to establish the clinical effectiveness of PET. Practical understanding of updated PET scanners, image process and quantification of PET measurements is also discussed. With contributions from leaders in the PET community, the book deals with the basic principles, instrumentation, fusion, radiopharmaceuticals, radiosynthesis, safety and cost analysis of PET. The clinical section of the book will focus on the technique and indications of PET. There is also a unique atlas as well as comprehensive coverage of essential clinical PET studies in neurology, cardiology, and oncology.

Clinical PET and PET/CT, 2nd Edition presents a valuable overview of the basic principles and clinical applications of PET and PET/CT. Emphasis is placed on the familiarization of normal distribution, artifacts, and common imaging agents such as FDG in conjunction with CT, MRI, and US to establish the clinical effectiveness of PET and PET/CT. Practical information about updated PET and PET/CT scanners, imaging processing, correlation, and quantification of PET and PET/CT measurements is also presented. This book is divided into two sections, the first half dealing with the basic principles of PET and PET/CT for instrumentation, fusion, radiopharmaceuticals, radiosynthesis, safety, and cost analysis. The second part of this volume presents chapters on the clinical techniques and applications of PET and PET/CT for common oncologic, cardiologic, and neurologic diseases. Numerous full color images provide comprehensive coverage on essential clinical PET and PET/CT studies.

This comprehensive volume covers radiopharmaceuticals developed for pathway-directed systems in imaging and theranostic applications. We now are at the cutting edge of providing personalized treatment with increased use in oncology of these new radiopharmaceuticals. Trends in high-resolution instrumentation development, quality assurance systems and regulatory compliance for radiopharmaceuticals, clinical evaluation of radiopharmaceuticals, and benefits and pitfalls of the current clinical FDG PET are discussed.

Radiopharmaceuticals are used for diagnosis of diseases of the central nervous and cardiovascular systems and for staging, restaging, and treatment planning for cancers. Nuclear biomarkers allow precise measurement of molecular pathways on a whole-body image upon administration of functional radiolabeled agents, and nuclear imaging agentshave potential use in patient selection, pharmacokinetic, dosage-finding, and proof-of-concept studies. Nuclear imaging agents and hybrid instrumentation also provide sensitive and specific answers for differential responsiveness in therapeutic outcome.

This book serves as a reference for moving the discovery and development of radiopharmaceuticals from the workbench to clinical applications. It thus benefits not only clinicians but also translational research scientists—molecular biologists, chemists, imaging scientists, pharmaceutical developers, physicists, and support staff.