Tomlinson - Böcker

This is a comprehensive account of British economic policy since 1900, covering both macro and micro issues and making full use of recent research, drawing on documents made available under the 30-year rule which reveal the formulation of policy through the 1950s. Broadly chronological in its approach, it offers both a coherent analysis and a clear narrative description of policy-making through the century. It is structured in such a way as to give due weight to the various influences on policy: institutional aspects (such as the changing role of policy-making ministries), political debate, and economic theory.

This volume will be of great value to all those researchers in the area of the inflam­ matory response, notably academics, clinicians and members of the pharmaceutical industry. The book has in the main been restricted to three inducible enzymes, namely nitric oxide synthase (iNOS), cyclooxygenase (COX-2) and hemeoxygenase (HO-l), although matrix metalloproteinases, xanthine oxidoreductase and tissue transgluta­ minases are reviewed. The modulation of these enzymes is viewed as possible novel therapeutic advances in the area of inflammation and also cancer. The latter topic may well be the subject of a further book. It will be interesting to observe the progress of such new therapies in the next decade. Already some of these enzyme modulators have been approved for the treat­ ment of inflammatory disease, as evidenced by the new families of COX-2 inhibitors. We believe such advances will herald a series of new and exciting agents to be included in the clinician's armamentarium in the constant struggle against inflammatory disease. The editors wish to thank all contributors to this volume on inducible enzymes. It should however be stressed that the views expressed by the authors are personal and do not necessarily reflect those of the editors. Indeed, the reader may find con­ flicting statements in a number of the chapters. We believe that this is entirely appro­ priate as this volume reflects the latest work in a rapidly developing area.