T.V.N. Persaud – författare

Menschliches Leben im EntstehenDieses Werk behandelt die Embryologie und Teratologie des Menschen von der Bildung der Keimzellen bis zur Geburt:Woche f�r Woche und Stadium f�r Stadium wird erl�utert, wie sich Blasteme, Organe und Organsysteme entwickeln.Histologische Mikrofotografien machen kritische Schritte der Entwicklung „erlebbar“.Molekulare Steuerungsmechanismen der Entwicklungs- und Stammzellbiologie - punktuell an Schl�sselstellen der Entwicklung erw�hnt - werden in einem eigenen Kapitel �bersichtlich zusammengefasst.Klinische Normalbefunde und Krankheitsbilder von Mutter und Kind w�hrend der Schwangerschaft sind mit zahlreichen Originalaufnahmen illustriert und kritischen Entwicklungsphasen samt molekularen Ursachen zugeordnet.Schemata, Tabellen und klassische Online-Animationen erleichtern das Verst�ndnis von komplexen, r�umlich und zeitlich parallellaufenden Entwicklungsstr�ngen.Vollst�ndige Literaturangaben verweisen auf bahnbrechende historische Originalbefunde und autoritative �bersichtsartikel neuer Erkenntnisse.Ein Fragenkatalog rundet jedes Kapitel ab und hilft, das Wissen zu �berpr�fen und zu vertiefen.Grundlage ist die englischsprachige Neuauflage des von Keith L. Moore begr�ndeten Embryologie-Klassikers aus den USA, adaptiert f�r das Human- und Zahnmedizinstudium und f�r die fach�bergreifende Fortbildung im deutschsprachigen Raum.Neu in der 7. deutschen Auflage:Originalfotografien neuer morphogenetischer Erkenntnisse, z.B. in der Fr�hentwicklung von Nervensystem, Gastrointestinaltrakt und GeschlechtsorganenAktualisierung von �ber 90 AbbildungenSystem�bergreifende Fehlbildungen als Klammer um die Morphologie der Entwicklung und ihre molekularen Steuerungsmechanismen am Ende des Buches.Das Buch eignet sich f�rStudenten der Human- und Zahnmedizin und ist Grundlage zur Fortbildung in der Fachdisziplin Embryologie.

Extensively revised to incorporate recent research and current clinical practice, The Developing Human: Clinically Oriented Embryology, South Asia Edition, covers all aspects of normal and abnormal embryonic and fetal development. In a clear, concise manner and lavishly illustrated throughout, this textbook is designed to successfully meet the needs of medical and health sciences profession students, as well as those in graduate programs. It provides an easy-to-digest, comprehensive review of what can be a complex and challenging subject.

The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intra-uterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mechanisms and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. This book brings together some of the more recent and important research findings related to the mechanisms and pathogenesis of abnormal develop­ ment. It is not only a documentation of the latest experimental work, but it also points out future directions that seem productive and challenging.

Surprisingly, the beginning of a modern approach This collection of articles and commentaries is an to the problems of birth defects is relatively recent integration of information from many disciplines, and dates from Gregg's classical report in 1941 that and presents a comprehensive survey of both recent mothers who contracted rubella during the first tri­ and previously reported work related to the major mester of pregnancy gave birth to infants with severe aspects of birth defects. In particular, an attempt multiple anomalies. For the first time, an environ­ has been made to provide a critical assessment of mental agent was found to be teratogenic in man current concepts and to identify areas in need of and was documented in a thoroughly convincing further investigation. manner. Since then, many important discoveries The scope of this volume and space limitations and significant developments have been made, par­ precluded discussion of and reference to all papers ticularly in the areas of environmental teratogenesis, of relevance or importance: a work of the present hereditary mechanisms, and prenatal diagnosis. nature must necessarily be selective. Some good In recent years, there has been an impressive papers have been left out or given relatively little surge of interest in the causes and prevention of consideration. It is my hope that the list of Further birth defects. Undoubtedly this resulted not only References will be consulted and should compensate from the thalidomide tragedy, but also from the for this lack of completeness.

The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intra-uterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mec.;hanisms and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. The· contributions in this volume deal primarily with the areas of terato­ logical evaluation and the use of selected animal models for the study of con­ genital anomalies. It is not only a documentation of the latest experimental work, but it also indicates new and important areas for future research.

The study of birth defects has assumed an importance even greater now than in the past because mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. It is estimated that as many as 50% of all pregnancies terminate as miscarriages. In the majority of cases this is the result of faulty development. Major congenital malformations are found in at least 2% of all liveborn infants, and 22% of all stillbirths and infant deaths are associated with severe congenital anomalies. Teratological studies of an experimental nature are neither ethical nor justifiable in humans. Numerous investigations have been carried out in laboratory animals and other experimental models in order to improve our understanding of abnormal intrauterine development. In less than two decades the field of experimental teratology has advanced phenomenally. As a result of the wide range of information that is now accumulating, it has become possible to obtain an insight into the causes, mechanisms, and prevention of birth defects. However, considerable work will be needed before these problems can be resolved. The comributions in this volume include some of the more recent and exciting observations on the cellular and molecular aspects of developmental defects. It is not only a documentation of the latest experimental work, but it also indicates new and important areas for future research.

Birth defects have assumed an importance even greater now than in the past because infant mortality rates attributed to congenital anomalies have declined far less than those for other causes of death, such as infectious and nutritional diseases. As many as 50 % of all pregnancies terminate as miscarriages, and in the majority of cases this is the result of faulty intrauterine development. Major congenital malformations are present in at least 2 % of all liveborn infants, and 22 % of all stillbirths and infant deaths are associated with severe congenital anomalies. Not surprisingly, there has been a great proliferation of research into the problems of developmental abnormalities over the past few decades. This series, Advances in the Study of Birth Defects, was conceived in order to provide a comprehensive focal source of up-to-date information for physi­ cians concerned with the health of the unborn child and for research workers in the fields of fetal medicine and birth defects. The first four volumes featured recent experimental work on selected areas of high priority and intensive investigation, including mechanisms of teratogenesis, teratological evaluation, molecular and cellular aspects of abnormal development, and neural and behavioural teratology. It seems logical and timely that the clinical aspects should now be presented. Accordingly, leading experts were invited to review a broad range of common problems from the standpoint of embryology, aetiology, clinical manifestations, diagnosis and management. This volume deals with genetic disorders and prenatal diagnosis.