Uwe Gottschalk – författare

Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification.•    Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing•    Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification•    Emphasizes antibodies and innovative chromatography methods for processing

Solve downstream bottlenecks with expert strategies for antibody purification With monoclonal antibody sales exceeding $210 billion and upstream productivity outpacing downstream capacity, manufacturers face urgent purification bottlenecks. Process Scale Purification of Antibodies, now in its Third Edition, assembles top-tier technology experts to address process-scale challenges. This established resource delivers practical solutions for each unit operation while maintaining the currency that biopharmaceutical professionals require. This edition updates protein A chromatography coverage, adds CMC considerations, addresses raw material control strategies, and introduces machine learning and AI applications in purification processes. Contributors provide fresh perspectives on traditional chromatography alongside innovative methods for processing antibodies at scale. The book consolidates proven approaches with emerging technologies to meet increasing production demands without sacrificing product quality. Readers will also find: Comprehensive coverage of purification strategies from leading experts addressing problems specific to each unit operation in antibody manufacturingUpdated guidance on protein A chromatography optimization and emerging alternatives for process-scale downstream operations in biopharmaceutical productionNew chapters covering CMC considerations and regulatory requirements essential for successful antibody drug development and manufacturing approvalPractical approaches to raw material control and quality assurance that support robust and economical large-scale purification processesApplications of machine learning and artificial intelligence to optimize purification workflows and improve process efficiency in downstream operationsPharmaceutical and biotech scientists, chemical engineers in biopharmaceutical processing, and professionals in product development or process science departments will find this resource indispensable. Process Scale Purification of Antibodies delivers the technical depth and practical guidance needed to overcome downstream bottlenecks and deliver pure therapeutic antibodies efficiently.