Vinod Patel – författare

Medical students are required to assimilate a huge amount of knowledge. However, to be effective practitioners, they must also be able to apply this knowledge in the context of patient care. Practical and Professional Clinical Skills sets out the full range of clinical skills that medicine students must be able to demonstrate.Compiled by editors with expertise in clinical skills education, the book has at its core a focus on professionalism, and on treating the patient with respect, dignity, and kindness.The book is divided into four suites:· History and Examination Skills · Procedural Skills · Emergency Skills · Professional SkillsTaken together, these suites provide unrivalled coverage of the subject.The book:Provides step-by-step procedures: with a balance of guidance, rationale and illustrative content.Relates skills to relevant basic science, be this anatomical (e.g. sites of injection), physiological (reactions), or microbiological (maintaining a sterile environment).Encourages the blended development of practical flair and professional competence, promoting the importance of learning skills in the context of professional domains, including communication skills.Encourages students to take advantage of appropriate opportunities to improve their techniques, maximise their confidence and foster a safe learning environment for themselves, and a safe clinical environment for their patients.Ensures students are mindful of patient status, seeking appropriate opportunities to undertake skills, and raising awareness of the well / unwell patientPrepares students to encounter medical emergencies, with indications of important first line management, and detail on structured management as part of the medical team.Alongside clear, step-by-step guidance, the book uses OSCE-style competency assessment checklists throughout to encourage the student to verify that they can correctly implement the guidance and skills presented.Practical and Professional Clinical Skills is the one resource you won't want to be without to ensure mastery of all clinical skills - and to ensure professional success.Online Resource CentreFor registered adopters of the text:Figures from the book, available to download.For all:Downloadable versions of the competency assessment checklists presented in the text.

With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future.Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing on hepatotoxicity in drug safety, cardiovascular toxicity and signaling effects via kinase and GPCR anti-targets. In the final section, several case studies of recently developed drugs illustrate how to prevent anti-target effects and how big pharma deals with them if they occur. The more recent field of systems pharmacology has gained prominence and this is reflected in chapters dedicated to the utility in deciphering and modeling anti-targets. The final chapter is concerned with those compounds that inadvertently elicit CNS mediated adverse events, including a pragmatic description of ways to mitigate these types of safety risks.Written as a companion to the successful book on antitargets by Vaz and Klabunde, this new volume focuses on recent progress and new classes, methods and case studies that were not previously covered.

With its focus on emerging concerns of kinase and GPCR-mediated antitarget effects, this vital reference for drug developers addresses one of the hot topics in drug safety now and in future. Divided into three major parts, the first section deals with novel technologies and includes the utility of adverse event reports to drug discovery, the translational aspects of preclinical safety findings, broader computational prediction of drug side-effects, and a description of the serotonergic system. The main part of the book looks at some of the most common antitarget-mediated side effects, focusing on hepatotoxicity in drug safety, cardiovascular toxicity and signaling effects via kinase and GPCR anti-targets. In the final section, several case studies of recently developed drugs illustrate how to prevent anti-target effects and how big pharma deals with them if they occur. The more recent field of systems pharmacology has gained prominence and this is reflected in chapters dedicated to the utility in deciphering and modeling anti-targets. The final chapter is concerned with those compounds that inadvertently elicit CNS mediated adverse events, including a pragmatic description of ways to mitigate these types of safety risks. Written as a companion to the successful book on antitargets by Vaz and Klabunde, this new volume focuses on recent progress and new classes, methods and case studies that were not previously covered.