Vladimir Sobolev – författare

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple.

Pathway models that aggregate the knowledge about protein-protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine.

This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease.

Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier's Disease Pathway Collection, published for the first time outside of Pathway Studio� commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple.Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine.This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease.- Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology.- Disease pathways are based on computational models from Elsevier''s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software.- Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

Brings together many important recent developments in the analysis of singular perturbation and hysteresis phenomena in an accessible and comprehensive fashion. To bridge a gap between analysts of these phenomena, the editors conducted a workshop in April 2002 at University College Cork in Ireland to provide a forum for experts in both fields to share their interests and knowledge. For this book, the editors have compiled research from those practitioners in areas such as reacting systems, semiconductor lasers, shock phenomena in economic modeling, and fluid mechanics, all with an emphasis on hysteresis and singular perturbations.The book begins with a basic introduction to hysteresis and singular perturbation theory, including simple examples from both physics and mathematics. Later chapters address:Applications of hysteresis to economics. Various aspects of the asymptotic theory of singularly perturbed systems. Typical problems of the asymptotic theory of contrast structures.The geometrical approach to an investigation of models with singular perturbations and hysteresis.The editors expect this text not only to be a useful and accessible introduction to techniques and the research literature but also to generate new ideas for researchers and to attract new researchers into this vibrant and dynamic field.

These lecture notes provide a fresh approach to investigating singularly perturbed systems using asymptotic and geometrical techniques. It gives many examples and step-by-step techniques, which will help beginners move to a more advanced level. Singularly perturbed systems appear naturally in the modelling of many processes that are characterized by slow and fast motions simultaneously, for example, in fluid dynamics and nonlinear mechanics. This book’s approach consists in separating out the slow motions of the system under investigation. The result is a reduced differential system of lesser order. However, it inherits the essential elements of the qualitative behaviour of the original system.  Singular Perturbations differs from other literature on the subject due to its methods and wide range of applications. It is a valuable reference for specialists in the areas of applied mathematics, engineering, physics, biology, as well as advanced undergraduates for the earlier parts of the book, and graduate students for the later chapters.