Wayne K. Goodman – författare

Neurotransmitters in the brain are the current focus of obsessive compulsive disorders to better address the approximately 2.5 million people in the United States diagnosed with OCD. As seems the way of psychiatry practice, a disorder is viewed and treated from one perspective for a period, then a new perspective is in the forefront. Such is the case with obsessive compulsive disorders, originally treated as a behavioral problem with psychotherapy, now considered a brain circuitry disorder that can be treated with psychopharmacotherapeutics. This issue contains topics that focus on neuroscience of the brain and genetics in relation to OCD, providing the psychiatrist a comprehensive review of the current thought, approach, diagnosis, and treatment related to OCD and its related disorders. Topics include: Etiological hypotheses of OCD - molecules to circuits; Models of obsessive compulsive and related disorders; Cognitive neuroscience of OCD; Genetics of obsessive compulsive and related disorders; Tic disorders - spearate or related disorder; Pediatric acute-onset neuropsychiatric syndrome (PANS); Body dysmorphic disorder; Trichotillomania; Hoarding disorder; Pharmacotherapy; Device based interventions; Cognitive behavioral therapy for OCD.

In this issue, guest editors bring their considerable expertise to this important topic.

Neurobiology of Obsessive-Compulsive Disorder provides a comprehensive review of obsessive-compulsive disorder through a neurobiological lens, offering invaluable insights for researchers and clinicians alike. The book begins with a comprehensive introduction to OCD, detailing its definition, historical perspectives, prevalence, and symptomatology, alongside its comorbidities and associated disorders. Delving into the genetic and familial aspects, the book examines genetic predispositions, heritability, and significant genome-wide association studies. In addition, it addresses neuropsychological findings, cognitive dysfunctions, and implications for treatment, alongside neurodevelopmental factors, including early life stress, immune system dysregulation, and environmental risk factors.Special attention is given to PANDAS/PANS as mechanisms of OCD pathogenesis and the insights gained from animal models. Subsequent chapters cover diagnosis, pharmacological treatments, and a range of psychotherapeutic and behavioral interventions, including CBT, ERP, and ACT, as well as neuromodulation techniques. Finally, the book presents neurobiology-informed treatment approaches, personalized medicine, and integrative strategies, concluding with discussions on current challenges, ethical considerations, and future research directions.Reviews the definition of OCD, historical perspectives, prevalence, symptomatology, and comorbiditiesExplores genetic predispositions, heritability, and the brain regions implicated in OCDExamines the roles of serotonin, dopamine, glutamate, and other neurotransmitters in the neurochemistry of OCDCovers pharmacological treatments and psychotherapeutic and behavioral interventions, including CBT, ERP, and neuromodulation techniquesDiscusses current research challenges, ethical considerations, promising research avenues, and future directions in the neurobiological treatment of OCD

Obsessive-compulsive disorder is now recognized to be a serious and chronic illness affecting more than 2% of the population. While the last decade of the twentieth century witnessed many advances on both the pharmacological and the behavioral fronts, fewer than 50% of cases benefitted significantly from treatments available at the time. In this volume, originally published in 2000, leading authorities offer a comprehensive, cutting-edge overview of etiology, diagnosis, assessment, and the latest cognitive-behavioral, biological, and combined approaches to intervention. A special focus is treatment-resistant illness.Obsessive-Compulsive Disorder: Contemporary Issues in Treatment will be an indispensable resource for all professionals who seek better solutions to the often seemingly intractable problems of their OCD clients.

Obsessive-compulsive disorder is now recognized to be a serious and chronic illness affecting more than 2% of the population. While the last decade of the twentieth century witnessed many advances on both the pharmacological and the behavioral fronts, fewer than 50% of cases benefitted significantly from treatments available at the time. In this volume, originally published in 2000, leading authorities offer a comprehensive, cutting-edge overview of etiology, diagnosis, assessment, and the latest cognitive-behavioral, biological, and combined approaches to intervention. A special focus is treatment-resistant illness.Obsessive-Compulsive Disorder: Contemporary Issues in Treatment will be an indispensable resource for all professionals who seek better solutions to the often seemingly intractable problems of their OCD clients.

Dieser Band geht auf den Kongre~ "Zwangsst|rungen" zur}ck, der im Oktober 1992 an der Psychiatrischen und Nervenklinik der Universit{t Hamburg stattfand. Von biologisch, pharmakologisch und verhaltenstherapeutisch orientierten internationalen Experten werden der aktuelle Kenntnisstand zur Epidemiologie und zu pharmakologischen und verhaltentherapeutischen Behandlungsm|glichkeiten der Zwangsst|rungen im Kindes- und Erwachsenenalter sowie Denkmodelle zuNeurobiologie, Ethiologie und Sozialpsychologie des Zwangsverhaltens dargestellt und diskutiert.