Wayne K. Goodman – författare

Neurotransmitters in the brain are the current focus of obsessive compulsive disorders to better address the approximately 2.5 million people in the United States diagnosed with OCD. As seems the way of psychiatry practice, a disorder is viewed and treated from one perspective for a period, then a new perspective is in the forefront. Such is the case with obsessive compulsive disorders, originally treated as a behavioral problem with psychotherapy, now considered a brain circuitry disorder that can be treated with psychopharmacotherapeutics. This issue contains topics that focus on neuroscience of the brain and genetics in relation to OCD, providing the psychiatrist a comprehensive review of the current thought, approach, diagnosis, and treatment related to OCD and its related disorders. Topics include: Etiological hypotheses of OCD - molecules to circuits; Models of obsessive compulsive and related disorders; Cognitive neuroscience of OCD; Genetics of obsessive compulsive and related disorders; Tic disorders - spearate or related disorder; Pediatric acute-onset neuropsychiatric syndrome (PANS); Body dysmorphic disorder; Trichotillomania; Hoarding disorder; Pharmacotherapy; Device based interventions; Cognitive behavioral therapy for OCD.

In this issue, guest editors bring their considerable expertise to this important topic.

Neurobiology of Obsessive-Compulsive Disorder provides a comprehensive review of obsessive-compulsive disorder through a neurobiological lens, offering invaluable insights for researchers and clinicians alike. The book begins with a comprehensive introduction to OCD, detailing its definition, historical perspectives, prevalence, and symptomatology, alongside its comorbidities and associated disorders. Delving into the genetic and familial aspects, the book examines genetic predispositions, heritability, and significant genome-wide association studies. In addition, it addresses neuropsychological findings, cognitive dysfunctions, and implications for treatment, alongside neurodevelopmental factors, including early life stress, immune system dysregulation, and environmental risk factors.Special attention is given to PANDAS/PANS as mechanisms of OCD pathogenesis and the insights gained from animal models. Subsequent chapters cover diagnosis, pharmacological treatments, and a range of psychotherapeutic and behavioral interventions, including CBT, ERP, and ACT, as well as neuromodulation techniques. Finally, the book presents neurobiology-informed treatment approaches, personalized medicine, and integrative strategies, concluding with discussions on current challenges, ethical considerations, and future research directions.Reviews the definition of OCD, historical perspectives, prevalence, symptomatology, and comorbiditiesExplores genetic predispositions, heritability, and the brain regions implicated in OCDExamines the roles of serotonin, dopamine, glutamate, and other neurotransmitters in the neurochemistry of OCDCovers pharmacological treatments and psychotherapeutic and behavioral interventions, including CBT, ERP, and neuromodulation techniquesDiscusses current research challenges, ethical considerations, promising research avenues, and future directions in the neurobiological treatment of OCD

The Mount Sinai Expert Guides, published by Wiley and endorsed by Mount Sinai School of Medicine in New York, provide rapid access, point-of-care clinical information on the most common diseases in a range of different therapeutic areas. Each title focuses on a different speciality and emphasis throughout is on providing rapid-access, clear clinical guidance to aid physicians with point-of-care management of their patients.Each title is edited by a renowned specialist from Mount Sinai, normally the Chair of the department, who is responsible for recruiting key faculty members to author the chapters. A chapter template has been developed to which each chapter author must adhere, so as to ensure complete consistency across all the chapters in each book and also across every book in the series. Accompanying each book is a companion website containing accessory materials such as case studies, video clips, MCQs, patient advice and PQRI/ICD codes.Mount Sinai Expert Guides: Psychiatry will provide specialist trainees and recently qualified specialists in psychiatry with an extremely clinical, affordable and accessible handbook covering the specialty. It will be used as both a point-of-care resource in the hospital and clinical setting, and also as a refresher guide during preparation for board exams and re-certification.Focused on providing 100% clinical guidance on the most common conditions that psychologists encounter, it will present the very best in expert information in an attractive, easy to navigate informative and well-structured manner, with features such as key points, potential pitfalls, management algorithms, and national/international guidelines on treatment.

Obsessive-compulsive disorder is now recognized to be a serious and chronic illness affecting more than 2% of the population. While the last decade of the twentieth century witnessed many advances on both the pharmacological and the behavioral fronts, fewer than 50% of cases benefitted significantly from treatments available at the time. In this volume, originally published in 2000, leading authorities offer a comprehensive, cutting-edge overview of etiology, diagnosis, assessment, and the latest cognitive-behavioral, biological, and combined approaches to intervention. A special focus is treatment-resistant illness.Obsessive-Compulsive Disorder: Contemporary Issues in Treatment will be an indispensable resource for all professionals who seek better solutions to the often seemingly intractable problems of their OCD clients.

Obsessive-compulsive disorder is now recognized to be a serious and chronic illness affecting more than 2% of the population. While the last decade of the twentieth century witnessed many advances on both the pharmacological and the behavioral fronts, fewer than 50% of cases benefitted significantly from treatments available at the time. In this volume, originally published in 2000, leading authorities offer a comprehensive, cutting-edge overview of etiology, diagnosis, assessment, and the latest cognitive-behavioral, biological, and combined approaches to intervention. A special focus is treatment-resistant illness.Obsessive-Compulsive Disorder: Contemporary Issues in Treatment will be an indispensable resource for all professionals who seek better solutions to the often seemingly intractable problems of their OCD clients.