Wei Dai – författare

Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called “checkpoints” – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based on their ability to target emerging checkpoint components. Checkpoint Responses in Cancer Therapy summarizes the advances made over the past 20 years, identifying components of cell-cycle checkpoints and their molecular regulation during checkpoint activation and validating the use of checkpoint proteins as targets for the development of anticancer drugs. This book’s distinguished panel of authors takes a close look at topics ranging from the major molecular players affecting DNA synthesis and the response to DNA damage to advances made in the identification of chemical compounds capable of inhibiting individual mitotic kinases. Illuminating and authoritative, Checkpoint Responses in Cancer Therapy offers a critical summary of findings for researchers in the pharmaceutical and biotechnology industries and a valuable resource for academic scientists in cancer research and the study of cell-cycle regulation, signal transduction and apoptosis.

This book offers a comprehensive examination of the concept, technical framework, and progression of product reliability in the manufacturing industry. It provides in-depth insights into the theories and technologies surrounding reliability analysis and optimization in manufacturing, including both mechanical and electronic component manufacturing and assembly processes.

With a practical focus, the book features real-world case studies from the industry to illustrate the theories and concepts presented. The book also includes clear tables and presentations to help readers compare various methods and understand the technical systems involved in analyzing, improving, and controlling reliability in the manufacturing process.

The authors have developed new tools to address reliability challenges in the production process and provide a comprehensive theoretical and methodological foundation to guide reliability analysis and optimization. The book is aimed at professional researchers, engineering executives, and personnel, as well as design and production technicians in the fields of quality and reliability engineering. It also serves as a useful reference for technicians and scholars working on solving reliability problems and enhancing quality in the manufacturing industry.