Wei Zheng – författare

Despite the existence of two barrier systems in the brain, research over the last century has mostly focused on the blood-brain barrier rather than on the blood-CSF barrier. Today, there is a greater understanding of the function of the blood-CSF barrier and of the choroid plexus, a tissue that is the primary site of this barrier. With the growing number of studies that focus on the role of the blood-CSF barrier in CNS homeostasis and neurological disorders, a modern overview of the blood-CSF barrier is long overdue.The Blood-Cerebrospinal Fluid Barrier is exclusively devoted to the blood-CSF barrier. Internationally renowned experts discuss the most recent progress in the field of choroid plexus physiology and update our knowledge of the function of the blood-CSF barrier. The book begins with an overview of the development and morphology of the choroid plexus, and then covers various aspects of its function, such as the regulation of choroidal blood flow, ion transport, and the production and transport of polypeptides. Following an extensive section on the role of the choroid plexus in CNS disorders, the final section discusses in vitro, in vivo, and in situ models of the blood-CSF barrier.This unique book analyzes a wealth of new research on the proven and potential roles of the choroid plexus/blood-CSF barrier in the brain. It is a valuable resource that will foster future studies in neuroscience, pharmacology, and toxicology.

Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.

This book discusses autonomous spacecraft navigation based on X-ray pulsars, analyzing how to process X-ray pulsar signals, how to simulate them, and how to estimate the pulse’s time of arrival based on epoch folding.

This book discusses autonomous spacecraft navigation based on X-ray pulsars, analyzing how to process X-ray pulsar signals, how to simulate them, and how to estimate the pulse’s time of arrival based on epoch folding. In turn, the book presents a range of X-ray pulsar-based spacecraft positioning/time-keeping/attitude determination methods. It also describes the error transmission mechanism of the X-ray pulsar-based navigation system and its corresponding compensation methods. Further, the book introduces readers to navigation based on multiple measurement information fusion, such as X-ray pulsar/traditional celestial body integrated navigation and X-ray pulsar/INS integrated navigation. As such, it offers readers extensive information on both the theory and applications of X-ray pulsar-based navigation, and reflects the latest developments in China and abroad. 

This book discusses autonomous spacecraft navigation based on X-ray pulsars, analyzing how to process X-ray pulsar signals, how to simulate them, and how to estimate the pulse’s time of arrival based on epoch folding.