Wen G. Jiang – författare
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Metastasis (spread of cancer in the body) is the main cause of death for patients with breast cancer, the leading female tumour in the industrialised countries and developing countries alike. The biology and treatment of breast cancer metastasis remains an active area of scientific and clinical investigation.
Written by experts in the subject area, the book has covered a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis, and diagnosis The book also covers the current treatment options including surgical management, chemotherapy and hormonal therapies. This timely book provides the current knowledge in the area of breast cancer metastasis and will be of important reading material for oncologists, radiologists, cancer researchers, biologists and health worker.
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There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.
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