William A Haseltine – författare

A Brookings Institution Press and the National University of Singapore Press publicationThis is the story of the Singapore healthcare system: how it works, how it is financed, its history, where it is going, and what lessons it may hold for national health systems around the world. Singapore ranks sixth in the world in healthcare outcomes, yet spends proportionally less on healthcare than any other high-income country. This is the first book to set out a comprehensive system-level description of healthcare in Singapore, with a view to understanding what can be learned from its unique system design and development path.The lessons from Singapore will be of interest to those currently planning the future of healthcare in emerging economies, as well as those engaged in the urgent debates on healthcare in the wealthier countries faced with serious long-term challenges in healthcare financing. Policymakers, legislators, public health officials responsible for healthcare systems planning, finance and operations, as well as those working on healthcare issues in universities and think tanks should understand how the Singapore system works to achieve affordable excellence.

How a public-private partnership led to the largest emergency response system in the worldEmergency medical response systems are a critical component of any nation''s healthcare system. Minutes or even seconds can mean the difference between life or death. Every Second Counts tells the inspiring story of how the Indian government and a non-profit foundation, the Emergency Management and Research Institute (EMRI), partnered to create a world-class emergency response system that serves more than 700 million people and has saved more than 2 million lives.What the government of India achieved in partnership with EMRI is nothing short of groundbreaking. In Every Second Counts, William A. Haseltine describes the key factors behind the success of EMRI: the application of cutting-edge technologies, an outstanding medical education system, and a close working partnership between a well-intentioned government and a capable non-profit partner.Every Second Counts is an important book for policymakers, business leaders, and healthcare leaders who care about providing high-quality care at affordable costs to all those in need.

The COVID-19 Textbook: Science, Medicine, and Public Health explores every facet of SARS-CoV-2, giving the reader an understanding of what is needed to control the spread of the virus, prevent and manage its pathological effects, as well as mitigate the impact of future pandemics. Each chapter is authored by leading global experts in the field and includes topics such as molecular biology, epidemiology, pathogenesis, immunology, diagnosis, and the latest prevention and treatment approaches. Edited by renowned educator and medical researcher Dr. William A. Haseltine, physician-researcher, and chronic fatigue syndrome expert Dr. Roberto Patarca, it includes detailed references in every chapter, allowing easy access to comprehensive primary data. - Offers a timely, reliable overview authored and edited by leading global experts in the multifaceted areas covered on SARS-CoV-2 and the COVID-19 pandemic. - Serves as an authoritative and comprehensive text to be utilized by physicians, medical professionals, researchers, students, public health professionals, and policymakers.

In the early stages of an RNA revolution, the potential of RNA technology to transform human and veterinary medicine, agriculture, and industry, is emergent in much the same way as the advent of recombinant DNA in the 1980s, which created and disrupted products and markets. The revolution has been heralded by the realization that RNA plays a more fundamental role in biology than that reflected in the classical central molecular biology dogma—DNA to RNA to protein to phenotype. The new consensus is that RNA plays a more fundamental role in biology, directly regulating protein function and phenotype. Non-protein coding RNA accounts for more than 95% of the transcriptional output of human, animal, and plant genomes and regulates gene expression, chromatin remodeling, and cellular growth. The number of noncoding RNAs exceeds that of protein-coding RNAs, including inherited changes, significantly increasing the number of inherited genes.This textbook offers a comprehensive overview of the biology of RNA and is a companion volume to The Biology of RNA: The Fundamentals, The Practical Applications of RNA: Medicine, and The Practical Applications of RNA: Agriculture and Industry. Chapters are structured to enhance learning and retention with the use of overviews, learning objectives, and clearly highlighted key concepts, definitions, and points to remember. Chapters are rounded out with case studies, exercises, and quizzes to encourage readers to think and apply new knowledge. Capturing the state of research and offering insight on emerging topics and future knowledge trends, this textbook is a pivotal resource for advanced students and researchers in molecular biology, and any reader interested in learning more about this rapidly advancing field.

In the early stages of an RNA revolution, the potential of RNA technology to transform human and veterinary medicine, agriculture, and industry, is emergent in much the same way as the advent of recombinant DNA in the 1980s, which created and disrupted products and markets. The revolution has been heralded by the realization that RNA plays a more fundamental role in biology than that reflected in the classical central molecular biology dogma—DNA to RNA to protein to phenotype. The new consensus is that RNA plays a more fundamental role in biology, directly regulating protein function and phenotype. Non-protein coding RNA accounts for more than 95% of the transcriptional output of human, animal, and plant genomes and regulates gene expression, chromatin remodeling, and cellular growth. The number of noncoding RNAs exceeds that of protein-coding RNAs, including inherited changes, significantly increasing the number of inherited genes.This textbook offers a comprehensive overview of the biology of RNA and is a companion volume to The Biology of RNA: The Fundamentals, The Practical Applications of RNA: Medicine, and The Practical Applications of RNA: Agriculture and Industry. Chapters are structured to enhance learning and retention with the use of overviews, learning objectives, and clearly highlighted key concepts, definitions, and points to remember. Chapters are rounded out with case studies, exercises, and quizzes to encourage readers to think and apply new knowledge. Capturing the state of research and offering insight on emerging topics and future knowledge trends, this textbook is a pivotal resource for advanced students and researchers in molecular biology, and any reader interested in learning more about this rapidly advancing field.

RNA technology is poised to drive a new era of discovery and innovation across human and veterinary medicine, agriculture, and industry—an inflection point as consequential as the recombinant DNA revolution of the 1980s. As the first comprehensive survey of noncoding RNAs, this textbook provides a timely and authoritative introduction to one of the most dynamic frontiers in modern biology. It offers a broad overview of RNA biology while serving as a companion volume to The Biology of RNA: Long and Small Non-coding RNAs, and two forthcoming volumes on the practical applications of RNA. Designed to promote learning and long-term retention, each chapter features overviews, learning objectives, and clearly highlighted key concepts, definitions, and key takeaways, along with case studies and quizzes that help readers apply what they have learned. Bringing together foundational discoveries, current research, and emerging directions, this textbook is an indispensable resource for undergraduate and graduate students, researchers, and all readers seeking a deeper understanding of this fast-moving field.Advance Praise for The Biology of RNA:“A rare RNA textbook that closes the gap between basic RNA biology and the clinical revolution unfolding around it.” – Ada E. Yonath, PhD, Nobel Prize in Chemistry 2009“Anyone who reads it will come away with a far better understanding and appreciation of this important molecule that is fundamental to all of our lives.” – Robert S. Langer, David H. Koch Institute Professor, MIT.

RNA technology is poised to drive a new era of discovery and innovation across human and veterinary medicine, agriculture, and industry—an inflection point as consequential as the recombinant DNA revolution of the 1980s. As the first comprehensive survey of noncoding RNAs, this textbook provides a timely and authoritative introduction to one of the most dynamic frontiers in modern biology. It offers a broad overview of RNA biology while serving as a companion volume to The Biology of RNA: Long and Small Non-coding RNAs, and two forthcoming volumes on the practical applications of RNA. Designed to promote learning and long-term retention, each chapter features overviews, learning objectives, and clearly highlighted key concepts, definitions, and key takeaways, along with case studies and quizzes that help readers apply what they have learned. Bringing together foundational discoveries, current research, and emerging directions, this textbook is an indispensable resource for undergraduate and graduate students, researchers, and all readers seeking a deeper understanding of this fast-moving field.Advance Praise for The Biology of RNA: “A rare RNA textbook that closes the gap between basic RNA biology and the clinical revolution unfolding around it.” – Ada E. Yonath, PhD, Nobel Prize in Chemistry 2009“Anyone who reads it will come away with a far better understanding and appreciation of this important molecule that is fundamental to all of our lives.” – Robert S. Langer, David H. Koch Institute Professor, MIT.

Demographic change is a defining issue of our time. As the worldwide population ages, the healthcare systems of every country will meet challenges of scale in providing for their elderly. Aging with Dignity: Innovation and Challenge in Sweden: The Voice of Elder Care Professionals is a study in the future of elder care through the lens of the Swedish healthcare system. Over the past year, ACCESS Health has conducted extensive interviews with more than thirty elder care professionals in Sweden. Aging with Dignity collects these in depth interviews alongside summary chapters and analysis. If a small, wealthy nation like Sweden, with well developed healthcare and social welfare systems, encounters difficulties adapting to demographic change, so too will other nations. By examining Sweden s healthcare coordination, homecare technology, dementia care, and eHealthcare initiatives, Aging with Dignity makes the case for best practices. It is our hope that readers will recognize as universal both the challenges and the innovative solutions presented here.

This open access book outlines the challenges of supporting the health and wellbeing of older adults around the world and offers examples of solutions designed by stakeholders, healthcare providers, and public, private and nonprofit organizations in the United States. The solutions presented address challenges including: providing person-centered long-term care, making palliative care accessible in all healthcare settings and the home, enabling aging-in-place, financing long-term care, improving care coordination and access to care, delivering hospital-level and emergency care in the home and retirement community settings, merging health and social care, supporting people living with dementia and their caregivers, creating communities and employment opportunities that are accessible and welcoming to those of all ages and abilities, and combating the stigma of aging. The innovative programs of support and care in Aging Well serve as models of excellence that, when put into action, move health spending toward a sustainable path and greatly contribute to the well-being of older adults.

Offering a thorough, accessible overview of the basic science and clinical data regarding the virus that causes COVID-19, Molecular Biology of SARS-CoV-2 is an excellent resource for researchers, clinical scientists, physicians, and students. This volume offers in-depth, extended content that originated with Drs. Roberto Patarca’s and William A. Haseltine’s chapter in The COVID-19 Textbook, edited by Dr. Haseltine and Dr. Patarca. The greatly expanded material in this text provides a much-needed primer in this complex area.   Reviews the basic science, clinical data and various perspectives on how SARS-CoV-2 infects cells, replicates, manipulates cellular machinery, evades host defenses, and is transmitted to other hosts Covers the origin and structure of SARS-CoV-2, followed by chapters based on the life cycle of the virusProvides a thorough review of what is known for each molecular component of the viral life cycle while incorporating information on pertinent prevention and therapeutic interventions  About the Authors  Roberto Patarca, MD, PhD  Dr. Patarca is the Chief Medical Officer at ACCESS Health International and a former pharmaceutical and medical device company executive and faculty at Harvard Medical School and the University of Miami. His research has focused on the AIDS virus, microbial replication regulation, adoptive cellular immunotherapy, drug resistance testing, cardiovascular interventions, and chronic fatigue syndrome.  He served on Advisory Committees to two U.S. Secretaries of Health and Human Services, was elected to the Academy of Sciences of Latin America; worked with the World Health Organization on standardization of cytokine level measurements, and has been published widely.William A. Haseltine, PhD  In Dr. Haseltine’s career at the forefront of medical research and application, he has educated a generation of doctors at Harvard Medical School, designed the strategy to develop the first treatment for HIV/AIDS, is well-known for his groundbreaking work on cancer, and led the team that pioneered the development of new drugs based on information from the human genome.  He is the author of more than two hundred peer-reviewed manuscripts and fifteen books. As Chair and CEO of ACCESS Health International, Dr. Haseltine is dedicated to ensuring that advances in medical technology translate to improved health outcomes worldwide.