William R. Taylor - Böcker

William Taylor's Cavalier and Yankee was one of the most famous works of American history written in the 1960s. The book is an intellectual history of the South before the Civil War, the perception of it in the North, and the effect it had upon the nation in the years from 1800 to 1860. First published in 1961 and out of print for several years, Taylor's classic study remains essential to the study of the pre-Civil War South.

Using a geometric perspective, Protein Geometry, Classification, Topology, and Symmetry reviews and analyzes the structural principals of proteins with the goal of revealing the underlying regularities in their construction. It also reviews computer methods for structure analysis and the automatic comparison and classification of these structures with an analysis of the statistical significance of comparing different shapes. Following an analysis of the current state of protein classification, the authors explore more abstract geometric and topological representations, including the occurrence of knotted topologies. The book concludes with a consideration of the origin of higher-level symmetries in protein structure.The authors focus on simple geometric methods that are deterministic rather than probabilistic and on the more abstract simplifications of protein structure that allow a better understanding of the overall fold of the structure. Most of the methods described in this book have corresponding computer programs. These can be found (as C source code) at the ftp site of the Division of Mathematical Biology at the National Institute for Medical Research. This collection of ideas contains pedagogical material that make it ideal for post-graduate courses as well as new ideas and results essential for researchers investigating protein structures.

Genomics and bioinformatics play an increasingly important and transformative role in medicine, society and agriculture. The mapping of the human genome has revealed 35,000 or so genes which might code for more than one protein, resulting in 100,000 proteins for the humans alone. Since proteins are attractive targets for developing drugs, efforts are now underway to map sequences and assign functions to many novel proteins. This book takes the novel approach to cover both the sequence and structure analysis of proteins in one volume and from an algorithmic perspective. Key features of the book include: Provides a comprehensive introduction to the analysis of protein sequence and structure analysis.Takes an algorithmic approach, relying on computational methods rather than theoretical.Provides an integrated presentation of theory, examples, exercises and applications.Includes coverage of both protein structure, and sequence, analysis.Accessible enough for biologists, yet rigorous enough for computer scientists and mathematicians.Supported by a Web site featuring exercises, solutions, images, and computer programs.Visit this website for exercises with solutions, computer programs, errata and additional material:http://www.ii.uib.no/proteinbioinformatics/

Using a geometric perspective, Protein Geometry, Classification, Topology, and Symmetry reviews and analyzes the structural principals of proteins with the goal of revealing the underlying regularities in their construction. It also reviews computer methods for structure analysis and the automatic comparison and classification of these structures with an analysis of the statistical significance of comparing different shapes. Following an analysis of the current state of protein classification, the authors explore more abstract geometric and topological representations, including the occurrence of knotted topologies. The book concludes with a consideration of the origin of higher-level symmetries in protein structure.The authors focus on simple geometric methods that are deterministic rather than probabilistic and on the more abstract simplifications of protein structure that allow a better understanding of the overall fold of the structure. Most of the methods described in this book have corresponding computer programs. These can be found (as C source code) at the ftp site of the Division of Mathematical Biology at the National Institute for Medical Research. This collection of ideas contains pedagogical material that make it ideal for post-graduate courses as well as new ideas and results essential for researchers investigating protein structures.

A unique volume, Inventing Times Square approaches the subject of twentieth-century American city culture through a multidimensional examination of one quintessential urban space: Times Square. Ranging in time from 1905, when the crossroad was given its present name, through to the current plans for redevelopment, the authors examine Times Square as economic hub, real estate bonanza, entertainment center, advertising medium, architectural experiment, and erotic netherworld. Though the volume centers on Times Square, the essays venture much further into urban history and American social history, revealing in the process how Times Square reflected-even epitomized-America as it became an urban consumer culture.