Wojciech Chrzanowski - Böcker

Extracellular and biofluids vesicles (EVs) are highly specialised yet ubiquitous nanoscale messengers secreted by cells. With the development of stem cell engineering, EVs promise to deliver next generation tools in regenerative medicine and tissue engineering, as well as in diagnostics. A vibrant and promising field, this book provides the first resource to the field.Covering basic cell biology, including EV production and intracellular communication, this book will provide material scientists and engineers with a foundation to the necessary biology. The reader will then learn about the isolation of extracellular vesicles their physicochemical characterisation and therapeutic application of EVs in regenerative medicine as well as their potential as biomarkers in medical diagnostic. This book will also discuss the regulatory landscape of EVs.Bridging cell biology, biomaterials, biophysics and biomedical engineering the content of this book is written with a broad interdisciplinary audience in mind. Researchers, new and established will find this a must-have on their shelf.

In order to design and develop new biomaterials it is essential to understand the biointerface, the interconnection between a synthetic or natural material and tissue, microorganism, cell, virus or biomolecule.Biointerfaces: Where Material Meets Biology provides an up to date overview of the knowledge and methods used to control living organism responses to implantable devices. The book starts with an introduction to the biointerface – past, present and the future perspectives and covers the key areas of biomolecular interface for cell modulation, topographical biointerface, mechano structural biointerafce, chemo-structural biointerfaces and interface that control bacteria responses. By combining the cellular, antimicrobial, antibacterial and therapeutic aspects of the interface with the methodology of fabrication and testing of the synthetic biomaterials used in a variety of medical applications the text provides a handbook for researchers.Edited by leading researchers, the book integrates the understanding of cell, microorganism and biomolecule interactions with surfaces and the methods used for assessment which will appeal to materials scientists, chemists, biotechnologists, (molecular-) biologists, biomedical engineers interested in the fundamentals and applications of biomaterials and biointerfaces.