Xia Li - Böcker

Cases in Laboratory Genetics and Genomics (LGG) Practice instructs readers in the lab-based diagnosis of genetic conditions, including inborn and acquired disorders using cytogenetics and molecular genetics technologies. This entirely case-based book covers a wide range of genetic cases, from prenatal to postnatal and oncology genetic disorders which lab professionals and geneticists encounter daily in the diagnostic field. Each disorder discussed includes a section on clinical background, clinical indication, tests ordered, laboratory tests performed, test results, results with interpretations, future testing and recommendations, and references.

The book will help lab professionals understand and navigate clinical cases using an integrative approach, and thoroughly understand the methodologies and interpretations involved in high complexity genetic testing.

Presents clinical cases illustrating the complexity of the genetic abnormalities and successful diagnoses Discusses the technologies best suited to detect DNA mutations, copy number variations, and chromosome or RNA translocations Aids lab professionals in ensuring tests ordered are optimal for clinical indications Prepares trainees for the American Board of Medical Genetics and Genomics (ABMGG) LGG course and exam

Zoulei is an endangered language spoken by several hundred speakers in China’s Guizhou Province and adjacent areas. It is a variety of the Ahou dialect of the highly diverse Gelao group within the Tai-Kadai language family. Zoulei is a typical isolating and analytic language, basically monosyllabic, particularly with verbs, with a number of striking features that are generally not found in other members of the Tai-Kadai family. The language is also marked by a rich phoneme inventory and lexical tone, compounding, serial verb constructions and strong head-initial constituent order, as well as a vocabulary that may enhance our understanding of the early history and culture of this region.In the opening chapters, the volume describes the social, cultural, and linguistic organization of this group, outlines the main points of Zoulei phonology, and presents an overview of the grammar. In succeeding chapters, it examines a number of grammatical topics in greater detail, including phrase and clause structure, verbal syntax, discourse particles, among others. The volume also includes a vocabulary and several texts recorded from village elders.

This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas.Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.