Xiang-Sun Zhang – författare

Alternative techniques and tools for analyzing biomolecular networks With the recent rapid advances in molecular biology, high-throughput experimental methods have resulted in enormous amounts of data that can be used to study biomolecular networks in living organisms. With this development has come recognition of the fact that a complicated living organism cannot be fully understood by merely analyzing individual components. Rather, it is the interactions of components or biomolecular networks that are ultimately responsible for an organism's form and function. This book addresses the important need for a new set of computational tools to reveal essential biological mechanisms from a systems biology approach.Readers will get comprehensive coverage of analyzing biomolecular networks in cellular systems based on available experimental data with an emphasis on the aspects of network, system, integration, and engineering. Each topic is treated in depth with specific biological problems and novel computational methods: GENE NETWORKS—Transcriptional regulation; reconstruction of gene regulatory networks; and inference of transcriptional regulatory networks PROTEIN INTERACTION NETWORKS—Prediction of protein-protein interactions; topological structure of biomolecular networks; alignment of biomolecular networks; and network-based prediction of protein function METABOLIC NETWORKS AND SIGNALING NETWORKS—Analysis, reconstruction, and applications of metabolic networks; modeling and inference of signaling networks; and other topics and new trends In addition to theoretical results and methods, many computational software tools are referenced and available from the authors' Web sites. Biomolecular Networks is an indispensable reference for researchers and graduate students in bioinformatics, computational biology, systems biology, computer science, and applied mathematics.

Alternative techniques and tools for analyzing biomolecular networks

With the recent rapid advances in molecular biology, high-throughput experimental methods have resulted in enormous amounts of data that can be used to study biomolecular networks in living organisms. With this development has come recognition of the fact that a complicated living organism cannot be fully understood by merely analyzing individual components. Rather, it is the interactions of components or biomolecular networks that are ultimately responsible for an organism''s form and function. This book addresses the important need for a new set of computational tools to reveal essential biological mechanisms from a systems biology approach.

Readers will get comprehensive coverage of analyzing biomolecular networks in cellular systems based on available experimental data with an emphasis on the aspects of network, system, integration, and engineering. Each topic is treated in depth with specific biological problems and novel computational methods:

GENE NETWORKS—Transcriptional regulation; reconstruction of gene regulatory networks; and inference of transcriptional regulatory networks

PROTEIN INTERACTION NETWORKS—Prediction of protein-protein interactions; topological structure of biomolecular networks; alignment of biomolecular networks; and network-based prediction of protein function

METABOLIC NETWORKS AND SIGNALING NETWORKS—Analysis, reconstruction, and applications of metabolic networks; modeling and inference of signaling networks; and other topics and new trends

In addition to theoretical results and methods, many computational software tools are referenced and available from the authors'' Web sites. Biomolecular Networks is an indispensable reference for researchers and graduate students in bioinformatics, computational biology, systems biology, computer science, and applied mathematics.

The first part of this work introduces concepts and algorithms in optimization theory which have been used in neural network research. The second covers main neural network models and their theoretical analysis and the third part introduces various neural network models for solving nonlinear programming problems and combinatorial optimization problems.

The book consists of three parts. The first part introduces concepts and algorithms in optimization theory, which have been used in neural network research. The second part covers main neural network models and their theoretical analysis. The third part of the book introduces various neural network models for solving nonlinear programming problems and combinatorial optimization problems. Audience: Graduate students and researchers who are interested in the intersection of optimization theory and artificial neural networks. The book is appropriate for graduate courses.

People are facing more and more NP-complete or NP-hard problems of a combinatorial nature and of a continuous nature in economic, military and management practice. There are two ways in which one can enhance the efficiency of searching for the solutions of these problems. The first is to improve the speed and memory capacity of hardware. We all have witnessed the computer industry''s amazing achievements with hardware and software developments over the last twenty years. On one hand many computers, bought only a few years ago, are being sent to elementary schools for children to learn the ABC''s of computing. On the other hand, with economic, scientific and military developments, it seems that the increase of intricacy and the size of newly arising problems have no end. We all realize then that the second way, to design good algorithms, will definitely compensate for the hardware limitations in the case of complicated problems. It is the collective and parallel computation property of artificial neural net­ works that has activated the enthusiasm of researchers in the field of computer science and applied mathematics. It is hard to say that artificial neural networks are solvers of the above-mentioned dilemma, but at least they throw some new light on the difficulties we face. We not only anticipate that there will be neural computers with intelligence but we also believe that the research results of artificial neural networks might lead to new algorithms on von Neumann''s computers.