Xiao-Hua Zhou – författare

Applied Missing Data Analysis in the Health Sciences A modern and practical guide to the essential concepts and ideas for analyzing data with missing observations in the field of biostatisticsWith an emphasis on hands-on applications, Applied Missing Data Analysis in the Health Sciences outlines the various statistical methods for the analysis of missing data. The authors acknowledge the limitations of established techniques and provide newly-developed methods with concrete applications in areas such as causal inference.Organized by types of data, chapter coverage begins with an overall introduction to the existence and limitations of missing data and continues into techniques for missing data inference, including likelihood-based, weighted GEE, multiple imputation, and Bayesian methods. The book subsequently covers cross-sectional, longitudinal, hierarchical, survival data. In addition, Applied Missing Data Analysis in the Health Sciences features: Multiple data sets that can be replicated using SAS®, Stata®, R, and WinBUGS software packagesNumerous examples of case studies to illustrate real-world scenarios and demonstrate applications of discussed methodologiesDetailed appendices to guide readers through the use of the presented data in various software environmentsApplied Missing Data Analysis in the Health Sciences is an excellent textbook for upper-undergraduate and graduate-level biostatistics courses as well as an ideal resource for health science researchers and applied statisticians.

The definitive resource for ensuring diagnostic tests meet the highest standards of statistical rigor and clinical effectiveness Statistical Methods in Diagnostic Medicine, 3rd Edition by Xiao-Hua Zhou, Jiarui Sun, Gene A. Pennello, Nancy A. Obuchowski and Donna K. McClish delivers the most comprehensive treatment of statistical methodologies for diagnostic test evaluation available today. The authors of the 2nd Edition – Peking University PKU Distinguished Chair Professor Zhou, Cleveland Clinic Professor Obuchowski, and Virginia Commonwealth University Professor Donna McClish – team with U.S. Food and Drug Administration senior mathematical statistician Pennello and doctoral researcher Sun to address a critical challenge facing medical professionals: ensuring that diagnostic tests used in clinical practice are accurate, methodologically sound, free from bias, and effective. This edition provides practitioners and researchers with the statistical foundation necessary to design, analyze, and validate diagnostic studies that can withstand regulatory scrutiny and clinical demands. The book has been thoroughly revised to incorporate the latest advances in diagnostic test methodology, featuring significant expansions in biomarker evaluation and benefit-risk assessment. The authors have restructured content to improve cohesion through integrated case studies that span multiple chapters, while updating each section with contemporary methods and streamlining discussions of older techniques to focus on the most relevant approaches for today’s diagnostic challenges. Readers will also find: Three entirely new chapters covering statistical methods for risk prediction, quantitative imaging biomarkers, and efficacy and effectiveness of biomarkers and other tests.Enhanced coverage of sample size calculations, accuracy estimation methods, and comparative analysis techniques for competing diagnostic testsAdvanced analytical approaches including methods for comparing correlated ROC curves in multi-reader studies and techniques for correcting verification biasComprehensive treatment of regression analysis applications in diagnostic accuracy research with updated methodological guidanceIntegrated case studies that demonstrate real-world application of statistical methods across different diagnostic scenarios and study designsPerfect for biostatisticians, applied statisticians, clinical researchers, and regulatory professionals working in diagnostic medicine, Statistical Methods in Diagnostic Medicine will also benefit graduate students and researchers interested in gaining the statistical expertise needed to design robust diagnostic studies.

Many different statistical methods have been developed for predicting the disease classes of patients. However, in order to have confidence in the results of such methods, their performance needs to be assessed. This handbook includes articles by the leading researchers in this area.

This book constitutes the revised selected papers of the 6th Pacific Causal Inference Conference, PCIC 2024, held in Shanghai, China, during July 5–6, 2024. The 8 papers included in these proceedings were carefully reviewed and selected from 15 submissions.